As of September 29, 2026, Lyra Therapeutics's top three insider holders are Maria Palasis (Principal Executive Officer, 1.09Mn shares), Jason Cavalier (Principal Financial Officer, 517.88K shares), Edward T Anderson (Director, 50.43K shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Maria Palasis | Principal Executive Officer | 1,094,733 | 0 | 1,094,733 | 62.9% | 03 Apr, 2026 |
| 2 | Jason Cavalier | Principal Financial Officer | 517,880 | 0 | 517,880 | 29.8% | 03 Apr, 2026 |
| 3 | Edward T Anderson | Director, TenPercentOwner | 0 | 50,435 | 50,435 | 2.9% | 02 Jun, 2023 |
| 4 | Gp, Llc Nbvm | TenPercentOwner | 0 | 50,435 | 50,435 | 2.9% | 02 Jun, 2023 |
| 5 | Advisors Llc Perceptive | TenPercentOwner | 0 | 14,026 | 14,026 | 0.8% | 13 Nov, 2025 |
| 6 | Harlan Waksal | Executive Chair | 10,739 | 0 | 10,739 | 0.6% | 20 Mar, 2024 |
| 7 | Corinne Noyes | Officer | 733 | 0 | 733 | 0.0% | 02 Feb, 2023 |
| 8 | Robert E. Richard | Svp, Technical Operations | 600 | 0 | 600 | 0.0% | 02 Feb, 2023 |
| 9 | C Ann Merrifield | Director | 227 | 0 | 227 | 0.0% | 13 Jun, 2022 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 14 May, 2026 | W Bradford Smith | Director | Disposed D | 640 | $0.00 | $0 | 0 | Direct |
| 01 Apr, 2026 | Maria Palasis | Principal Executive Officer | Disposed D | 2,000 | $0.00 | $0 | 1,094,733 | Direct |
| 01 Apr, 2026 | Jason Cavalier | Principal Financial Officer | Disposed D | 667 | $0.00 | $0 | 517,880 | Direct |
| 06 Jan, 2026 | Maria Palasis | President Ceo | Disposed S | 1,702 | $3.36 | $5.73K | 1,096,733 | Direct |
| 06 Jan, 2026 | Jason Cavalier | Chief Financial Officer | Disposed S | 769 | $3.36 | $2.59K | 518,547 | Direct |
| 11 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 4,783 | $4.31 | $20.64K | 161,318 | Indirect |
| 11 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 537 | $4.31 | $2.32K | 18,122 | Indirect |
| 12 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 7,862 | $4.06 | $31.92K | 153,456 | Indirect |
| 12 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 883 | $4.06 | $3.58K | 17,239 | Indirect |
| 13 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 28,597 | $3.90 | $111.53K | 124,859 | Indirect |
| 13 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 3,213 | $3.90 | $12.53K | 14,026 | Indirect |
| 06 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 28,902 | $5.18 | $149.71K | 200,480 | Indirect |
| 06 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 3,247 | $5.18 | $16.82K | 22,521 | Indirect |
| 07 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 17,746 | $4.75 | $84.23K | 182,734 | Indirect |
| 07 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 1,993 | $4.75 | $9.46K | 20,528 | Indirect |
| 10 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 16,633 | $4.54 | $75.51K | 166,101 | Indirect |
| 10 Nov, 2025 | Advisors Llc Perceptive | TenPercentOwner | Disposed S | 1,869 | $4.54 | $8.48K | 18,659 | Indirect |
| 01 Oct, 2025 | Maria Palasis | President Ceo | Acquired A | 3,667 | $0.00 | $0 | 7,333 | Direct |
| 10 Jul, 2025 | Jason Cavalier | Chief Financial Officer | Disposed S | 684 | $8.91 | $6.09K | 519,316 | Direct |
| 10 Jul, 2025 | Maria Palasis | President Ceo | Disposed S | 1,565 | $8.91 | $13.94K | 1,098,435 | Direct |