Lyra Therapeutics (LYRA) Free Cash Flow (2019 - 2025)
Quarterly Free Cash Flow rose 45.44% to -$6.2 million in Q4 2025 from the year-ago period, while the trailing twelve-month figure was -$29.0 million through Dec 2025, up 59.98% year-over-year, with the annual reading at -$29.0 million for FY2025, 59.95% up from the prior year.
Lyra Therapeutics' Free Cash Flow history spans 7 years, with the latest figure at -$6.2 million for Q4 2025.
- Free Cash Flow came in at -$6.2 million for Q4 2025, up from -$7.4 million in the prior quarter.
- In the past five years, Free Cash Flow ranged from a high of $2.8 million in Q2 2021 to a low of -$22.8 million in Q1 2024.
- The 5-year median for Free Cash Flow is -$11.6 million (2022), against an average of -$11.9 million.
- Year-over-year, Free Cash Flow soared 136.75% in 2021 and then crashed 404.17% in 2022.
- Lyra Therapeutics' Free Cash Flow stood at -$13.6 million in 2021, then grew by 10.57% to -$12.2 million in 2022, then tumbled by 61.36% to -$19.7 million in 2023, then surged by 42.59% to -$11.3 million in 2024, then skyrocketed by 45.44% to -$6.2 million in 2025.
- Per Business Quant, the three most recent readings for LYRA's Free Cash Flow are -$6.2 million (Q4 2025), -$7.4 million (Q3 2025), and -$6.6 million (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Free Cash Flow (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | -1.67 Mn |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | -12.20 Mn |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | -2.49 Mn |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 1.29 Bn |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 848.30 Mn |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | - |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 48.67 Mn |
| 10 | Lyra Therapeutics | - | - | - | -6.16 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -6.16 Mn |
| Dec 31, 2025 | -6.16 Mn |
| Sep 30, 2025 | -7.36 Mn |
| Sep 30, 2025 | -7.36 Mn |
| Jun 30, 2025 | -6.59 Mn |
| Jun 30, 2025 | -6.59 Mn |
| Mar 31, 2025 | -8.84 Mn |
| Mar 31, 2025 | -8.84 Mn |
| Dec 31, 2024 | -11.29 Mn |
| Dec 31, 2024 | -11.29 Mn |
| Sep 30, 2024 | -18.56 Mn |
| Sep 30, 2024 | -18.56 Mn |
| Jun 30, 2024 | -19.70 Mn |
| Jun 30, 2024 | -19.70 Mn |
| Mar 31, 2024 | -22.81 Mn |
| Mar 31, 2024 | -22.81 Mn |
| Dec 31, 2023 | -19.67 Mn |
| Dec 31, 2023 | -19.67 Mn |
| Sep 30, 2023 | -14.01 Mn |
| Sep 30, 2023 | -14.01 Mn |
| Jun 30, 2023 | -14.35 Mn |
| Jun 30, 2023 | -14.35 Mn |
| Mar 31, 2023 | -15.90 Mn |
| Mar 31, 2023 | -15.90 Mn |
| Dec 31, 2022 | -12.19 Mn |
| Dec 31, 2022 | -12.19 Mn |
| Sep 30, 2022 | -10.98 Mn |
| Sep 30, 2022 | -10.98 Mn |
| Jun 30, 2022 | -8.38 Mn |
| Jun 30, 2022 | -8.38 Mn |
| Mar 31, 2022 | -12.00 Mn |
| Mar 31, 2022 | -12.00 Mn |
| Dec 31, 2021 | -13.63 Mn |
| Dec 31, 2021 | -13.63 Mn |
| Sep 30, 2021 | -9.58 Mn |
| Sep 30, 2021 | -9.58 Mn |
| Jun 30, 2021 | 2.76 Mn |
| Jun 30, 2021 | 2.76 Mn |
| Mar 31, 2021 | -8.75 Mn |
| Mar 31, 2021 | -8.75 Mn |
| Dec 31, 2020 | -5.40 Mn |
| Dec 31, 2020 | -5.40 Mn |
| Sep 30, 2020 | -4.42 Mn |
| Sep 30, 2020 | -4.42 Mn |
| Jun 30, 2020 | -7.50 Mn |
| Jun 30, 2020 | -7.50 Mn |
| Mar 31, 2020 | -4.03 Mn |
| Mar 31, 2020 | -4.03 Mn |
| Dec 31, 2019 | -3.79 Mn |
| Dec 31, 2019 | -3.79 Mn |
| Sep 30, 2019 | -3.84 Mn |
| Sep 30, 2019 | -3.84 Mn |
| Jun 30, 2019 | -3.07 Mn |
| Jun 30, 2019 | -3.07 Mn |
| Mar 31, 2019 | -3.06 Mn |
| Mar 31, 2019 | -3.06 Mn |