Lyra Therapeutics (LYRA) EBT Margin (2021 - 2025)
Lyra Therapeutics' EBT Margin came in at -99271.43% for Q4 2025, down 94021.19 percentage points from -5250.24% a year earlier and down 75347.43 percentage points from the prior quarter.
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Analysis
Lyra Therapeutics (LYRA) EBT Margin (2021 - 2025) Analysis & Trends
For FY2025, Lyra Therapeutics' EBT Margin was -7263.32%, down 1174.92 percentage points from FY2024.
- EBT Margin carries a four-year change of +8004.40 percentage points (FY2021 to FY2025).
- Going back by year, EBT Margin was -6088.40% in FY2024 (-2069.08 pp), -4019.32% in FY2023 (+35.34 pp), -4054.66% in FY2022 (+11213.06 pp) and -15267.72% in FY2021.
- The Q4 2025 figure represents the lowest quarterly EBT Margin since Q4 2022.
- Year-over-year, EBT Margin increased in two of the last eight quarters, with an average year-over-year change of -13914.33 percentage points.
- The fastest year-over-year change in EBT Margin over five years came in Q4 2023 (a gain of 118921.73 percentage points), and the weakest in Q4 2022 (a drop of 124266.19 percentage points).
- Business Quant data shows LYRA's EBT Margin at -23924.00% (Q3 2025), -4062.84% (Q2 2025) and -4668.31% (Q1 2025) in the three quarters before Q4 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 26.66% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | 25.18% |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | -4.11% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 29.63% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 18.19% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 27.53% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -131.41% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | -4.34% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 41.75% |
| 10 | Lyra Therapeutics | 354,976.41 | 354,976.41 | - | -99,271.43% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -99,271.43% |
| Sep 30, 2025 | -23,924.00% |
| Jun 30, 2025 | -4,062.84% |
| Mar 31, 2025 | -4,668.31% |
| Dec 31, 2024 | -5,250.24% |
| Sep 30, 2024 | -6,085.13% |
| Jun 30, 2024 | -8,046.66% |
| Mar 31, 2024 | -4,217.67% |
| Dec 31, 2023 | -10,369.18% |
| Sep 30, 2023 | -2,874.08% |
| Jun 30, 2023 | -3,407.42% |
| Mar 31, 2023 | -3,961.22% |
| Dec 31, 2022 | -129,290.91% |
| Sep 30, 2022 | -4,113.09% |
| Jun 30, 2022 | -2,736.38% |
| Mar 31, 2022 | -2,545.09% |
| Dec 31, 2021 | -5,024.72% |
| Sep 30, 2021 | -78,964.29% |
API Access
Lyra Therapeutics EBT Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebt-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebt-margin", "ticker": "LYRA", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebt-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEY");
const data = await res.json();