Lyra Therapeutics (LYRA) EBITDA Margin (2021 - 2025)
Quarterly EBITDA Margin fell 9403732.0% to 99300.0% in Q4 2025 from the year-ago period, while the trailing twelve-month figure was 7266.08% through Dec 2025, down 117299.0% year-over-year, with the annual reading at 7266.08% for FY2025, 117299.0% down from the prior year.
Lyra Therapeutics' EBITDA Margin history spans 5 years, with the latest figure at 99300.0% for Q4 2025.
- EBITDA Margin came in at 99300.0% for Q4 2025, down from 23936.0% in the prior quarter.
- In the past five years, EBITDA Margin ranged from a high of 2545.09% in Q1 2022 to a low of 129318.18% in Q4 2022.
- The 5-year median for EBITDA Margin is 4847.61% (2021), against an average of 22160.93%.
- Year-over-year, EBITDA Margin plummeted -12429346bps in 2022 and then surged 11896476bps in 2023.
- Lyra Therapeutics' EBITDA Margin stood at 5024.72% in 2021, then plummeted by -2474bps to 129318.18% in 2022, then skyrocketed by 92bps to 10353.42% in 2023, then soared by 49bps to 5262.68% in 2024, then crashed by -1787bps to 99300.0% in 2025.
- Per Business Quant, the three most recent readings for LYRA's EBITDA Margin are 99300.0% (Q4 2025), 23936.0% (Q3 2025), and 4063.93% (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | - |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | -6.43% |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 38.10% |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 18.35% |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | - |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 17.24% |
| 10 | Lyra Therapeutics | - | - | - | -99,300.00% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -99,300.00% |
| Sep 30, 2025 | -23,936.00% |
| Jun 30, 2025 | -4,063.93% |
| Mar 31, 2025 | -4,670.49% |
| Dec 31, 2024 | -5,262.68% |
| Sep 30, 2024 | -6,076.41% |
| Jun 30, 2024 | -8,053.51% |
| Mar 31, 2024 | -4,221.80% |
| Dec 31, 2023 | -10,353.42% |
| Sep 30, 2023 | -2,873.35% |
| Jun 30, 2023 | -3,413.32% |
| Mar 31, 2023 | -3,970.00% |
| Dec 31, 2022 | -129,318.18% |
| Sep 30, 2022 | -4,113.09% |
| Jun 30, 2022 | -2,736.38% |
| Mar 31, 2022 | -2,545.09% |
| Dec 31, 2021 | -5,024.72% |
| Sep 30, 2021 | -78,964.29% |