Lyra Therapeutics (LYRA) EBITDA Margin (2021 - 2025)
Lyra Therapeutics (LYRA) reported EBITDA Margin of -100842.86% for Q4 2025, down 95470.61 percentage points from -5372.25% a year earlier and down 76294.86 percentage points from the prior quarter.
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Analysis
Lyra Therapeutics (LYRA) EBITDA Margin (2021 - 2025) Analysis & Trends
For FY2025, Lyra Therapeutics posted EBITDA Margin of -7679.15%, down 1430.91 percentage points from FY2024.
- EBITDA Margin has declined for three consecutive years, though with a four-year change of +7273.13 percentage points (FY2021 to FY2025).
- By year, EBITDA Margin came in at -6248.24% in FY2024 (-1959.41 pp), -4288.83% in FY2023 (-238.50 pp), -4050.33% in FY2022 (+10901.95 pp) and -14952.28% in FY2021.
- The Q4 2025 figure ranks as the lowest quarterly EBITDA Margin since Q4 2022.
- Year over year, EBITDA Margin gained in two of the last eight quarters, with an average year-over-year change of -14098.25 percentage points.
- The high point for year-over-year EBITDA Margin in five years was Q4 2023 (a gain of 124242.22 percentage points); the low point was Q4 2022 (a drop of 130524.66 percentage points).
- Per Business Quant data, the three quarters before Q4 2025 came in at -24548.00% (Q3 2025), -4713.66% (Q2 2025) and -4761.20% (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 35.95% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | 49.01% |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 6.02% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | - |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 33.11% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 46.01% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -124.26% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 39.16% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 39.10% |
| 10 | Lyra Therapeutics | 354,976.41 | 354,976.41 | - | -100,842.86% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -100,842.86% |
| Sep 30, 2025 | -24,548.00% |
| Jun 30, 2025 | -4,713.66% |
| Mar 31, 2025 | -4,761.20% |
| Dec 31, 2024 | -5,372.25% |
| Sep 30, 2024 | -6,370.26% |
| Jun 30, 2024 | -8,156.19% |
| Mar 31, 2024 | -4,396.24% |
| Dec 31, 2023 | -11,212.33% |
| Sep 30, 2023 | -3,105.70% |
| Jun 30, 2023 | -3,608.30% |
| Mar 31, 2023 | -4,153.41% |
| Dec 31, 2022 | -135,454.55% |
| Sep 30, 2022 | -4,046.24% |
| Jun 30, 2022 | -2,685.71% |
| Mar 31, 2022 | -2,488.25% |
| Dec 31, 2021 | -4,929.89% |
| Sep 30, 2021 | -76,292.86% |
API Access
Lyra Therapeutics EBITDA Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebitda-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebitda-margin", "ticker": "LYRA", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebitda-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEY");
const data = await res.json();