Lyra Therapeutics (LYRA) Net Margin (2021 - 2025)
Lyra Therapeutics' Net Margin came in at -99300.00% for Q4 2025, down 94046.89 percentage points from -5253.11% a year earlier and down 75364.00 percentage points from the prior quarter.
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Analysis
Lyra Therapeutics (LYRA) Net Margin (2021 - 2025) Analysis & Trends
For FY2025, Lyra Therapeutics' Net Margin was -7266.08%, down 1175.14 percentage points from FY2024.
- Net Margin carries a four-year change of +8001.64 percentage points (FY2021 to FY2025).
- Going back by year, Net Margin was -6090.94% in FY2024 (-2066.55 pp), -4024.39% in FY2023 (+32.84 pp), -4057.23% in FY2022 (+11210.49 pp) and -15267.72% in FY2021.
- The Q4 2025 figure represents the lowest quarterly Net Margin since Q4 2022.
- Year-over-year, Net Margin increased in two of the last eight quarters, with an average year-over-year change of -13915.53 percentage points.
- The fastest year-over-year change in Net Margin over five years came in Q4 2023 (a gain of 119214.57 percentage points), and the weakest in Q4 2022 (a drop of 124585.84 percentage points).
- Business Quant data shows LYRA's Net Margin at -23936.00% (Q3 2025), -4063.93% (Q2 2025) and -4670.49% (Q1 2025) in the three quarters before Q4 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 645.01 Bn | 563.54 Bn | 17.26 Bn | 21.86% |
| 2 | AbbVie | 465.23 Bn | 438.39 Bn | 12.70 Bn | 21.27% |
| 3 | Merck | 368.40 Bn | 322.83 Bn | 12.21 Bn | -8.04% |
| 4 | Novartis Ag | 278.02 Bn | 233.89 Bn | 11.24 Bn | 22.61% |
| 5 | Astrazeneca | 254.57 Bn | 228.13 Bn | 12.86 Bn | 18.81% |
| 6 | Amgen | 229.02 Bn | 184.42 Bn | 7.24 Bn | 23.62% |
| 7 | Gilead Sciences | 187.74 Bn | 161.85 Bn | 6.22 Bn | -134.51% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | -1.65% |
| 9 | Vertex Pharmaceuticals | 133.45 Bn | 105.45 Bn | 2.84 Bn | 32.99% |
| 10 | Lyra Therapeutics | 354,976.41 | 354,976.41 | - | -99,300.00% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -99,300.00% |
| Sep 30, 2025 | -23,936.00% |
| Jun 30, 2025 | -4,063.93% |
| Mar 31, 2025 | -4,670.49% |
| Dec 31, 2024 | -5,253.11% |
| Sep 30, 2024 | -6,088.72% |
| Jun 30, 2024 | -8,048.66% |
| Mar 31, 2024 | -4,220.30% |
| Dec 31, 2023 | -10,394.52% |
| Sep 30, 2023 | -2,877.02% |
| Jun 30, 2023 | -3,410.04% |
| Mar 31, 2023 | -3,964.63% |
| Dec 31, 2022 | -129,609.09% |
| Sep 30, 2022 | -4,113.09% |
| Jun 30, 2022 | -2,736.38% |
| Mar 31, 2022 | -2,545.09% |
| Dec 31, 2021 | -5,023.25% |
| Sep 30, 2021 | -78,964.29% |
API Access
Lyra Therapeutics Net Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=net-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "net-margin", "ticker": "LYRA", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=net-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEY");
const data = await res.json();