Lyra Therapeutics (LYRA) EBIT Margin (2021 - 2025)
Lyra Therapeutics' EBIT Margin was -101685.71% in Q4 2025, down 96227.34 percentage points from -5458.37% a year earlier and down 76737.71 percentage points from the prior quarter.
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Analysis
Lyra Therapeutics (LYRA) EBIT Margin (2021 - 2025) Analysis & Trends
For FY2025, EBIT Margin at Lyra Therapeutics came in at -7794.47%, down 1513.64 percentage points from FY2024.
- EBIT Margin has now declined for three consecutive years, though with a four-year change of +7509.04 percentage points (FY2021 to FY2025).
- In earlier years, EBIT Margin was -6280.83% in FY2024 (-1972.75 pp), -4308.09% in FY2023 (-177.05 pp), -4131.03% in FY2022 (+11172.47 pp) and -15303.51% in FY2021.
- The Q4 2025 figure marks the lowest quarterly EBIT Margin since Q4 2022.
- Compared with a year earlier, EBIT Margin was higher in two of the last eight quarters, with an average year-over-year change of -14260.38 percentage points.
- The best year-over-year quarter for EBIT Margin over five years was Q4 2023 (a gain of 126487.11 percentage points); the worst was Q4 2022 (a drop of 132740.25 percentage points).
- Per Business Quant data, LYRA's EBIT Margin in the three quarters before Q4 2025 was -24948.00% (Q3 2025), -4822.95% (Q2 2025) and -4831.15% (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBIT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 645.01 Bn | 563.54 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 465.23 Bn | 438.39 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 368.40 Bn | 322.83 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 278.02 Bn | 233.89 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 254.57 Bn | 228.13 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 229.02 Bn | 184.42 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 187.74 Bn | 161.85 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.45 Bn | 105.45 Bn | 2.84 Bn | 37.40% |
| 10 | Lyra Therapeutics | 354,976.41 | 354,976.41 | - | -101,685.71% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -101,685.71% |
| Sep 30, 2025 | -24,948.00% |
| Jun 30, 2025 | -4,822.95% |
| Mar 31, 2025 | -4,831.15% |
| Dec 31, 2024 | -5,458.37% |
| Sep 30, 2024 | -6,380.51% |
| Jun 30, 2024 | -8,189.63% |
| Mar 31, 2024 | -4,421.80% |
| Dec 31, 2023 | -11,285.62% |
| Sep 30, 2023 | -3,093.20% |
| Jun 30, 2023 | -3,603.28% |
| Mar 31, 2023 | -4,222.68% |
| Dec 31, 2022 | -137,772.73% |
| Sep 30, 2022 | -4,129.81% |
| Jun 30, 2022 | -2,742.86% |
| Mar 31, 2022 | -2,548.08% |
| Dec 31, 2021 | -5,032.47% |
| Sep 30, 2021 | -79,150.00% |
API Access
Lyra Therapeutics EBIT Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebit-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebit-margin", "ticker": "LYRA", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebit-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEY");
const data = await res.json();