Lyra Therapeutics (LYRA) Invested Capital (2019 - 2025)
Quarterly Invested Capital fell 192.44% to -$10.7 million in Q4 2025 from the year-ago period, while the trailing twelve-month figure was -$10.7 million through Dec 2025, down 192.44% year-over-year, with the annual reading at -$10.7 million for FY2025, 192.44% down from the prior year.
Lyra Therapeutics' Invested Capital history spans 7 years, with the latest figure at -$10.7 million for Q4 2025.
- Invested Capital came in at -$10.7 million for Q4 2025, down from -$4.3 million in the prior quarter.
- In the past five years, Invested Capital ranged from a high of $106.2 million in Q2 2022 to a low of -$10.7 million in Q4 2025.
- The 5-year median for Invested Capital is $52.3 million (2021), against an average of $49.0 million.
- Year-over-year, Invested Capital soared 184.18% in 2023 and then plummeted 192.44% in 2025.
- Lyra Therapeutics' Invested Capital stood at $34.3 million in 2021, then skyrocketed by 135.32% to $80.8 million in 2022, then increased by 10.73% to $89.4 million in 2023, then crashed by 87.03% to $11.6 million in 2024, then tumbled by 192.44% to -$10.7 million in 2025.
- Per Business Quant, the three most recent readings for LYRA's Invested Capital are -$10.7 million (Q4 2025), -$4.3 million (Q3 2025), and $1.6 million (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Invested Cap. (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | 595,226.00 |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | - |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | 110.96 Mn |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | 14.38 Mn |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 19.36 Bn |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 31.42 Bn |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | - |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 1.08 Bn |
| 10 | Lyra Therapeutics | - | - | - | -10.72 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -10.72 Mn |
| Sep 30, 2025 | -4.33 Mn |
| Jun 30, 2025 | 1.60 Mn |
| Mar 31, 2025 | 3.87 Mn |
| Dec 31, 2024 | 11.59 Mn |
| Sep 30, 2024 | 20.62 Mn |
| Jun 30, 2024 | 30.98 Mn |
| Mar 31, 2024 | 77.50 Mn |
| Dec 31, 2023 | 89.42 Mn |
| Sep 30, 2023 | 84.24 Mn |
| Jun 30, 2023 | 98.58 Mn |
| Mar 31, 2023 | 66.09 Mn |
| Dec 31, 2022 | 80.75 Mn |
| Sep 30, 2022 | 93.22 Mn |
| Jun 30, 2022 | 106.25 Mn |
| Mar 31, 2022 | 23.26 Mn |
| Dec 31, 2021 | 34.32 Mn |
| Sep 30, 2021 | 47.19 Mn |
| Jun 30, 2021 | 57.50 Mn |
| Mar 31, 2021 | 67.55 Mn |
| Dec 31, 2020 | 74.49 Mn |
| Sep 30, 2020 | 80.91 Mn |
| Jun 30, 2020 | 86.82 Mn |
| Mar 31, 2020 | -126.78 Mn |
| Dec 31, 2019 | -123.34 Mn |
| Sep 30, 2019 | -119.01 Mn |
| Jun 30, 2019 | -114.84 Mn |
| Mar 31, 2019 | -110.69 Mn |