Lyra Therapeutics (LYRA) Return on Sales (2021 - 2025)
Lyra Therapeutics (LYRA) recorded quarterly Return on Sales of 1.24% in Q4 2025, up 48.08% on a QoQ basis from 2.39% in Q3 2025, and down 166.0% YoY from 1.88% in Q4 2024.
Lyra Therapeutics (LYRA) Return on Sales (2021 - 2025) Analysis & Trends
Lyra Therapeutics (LYRA) has reported Return on Sales for 5 consecutive years, with 1.24% the latest figure, recorded in Q4 2025.
- Return on Sales for Q4 2025 came in at 1.24%, down 166.0% year-over-year; the trailing twelve-month figure through Dec 2025 was 0.57% (down 9.0% YoY), and the FY2025 annual result was 0.57%, down 9.0% from the prior year.
- Return on Sales for Q4 2025 stood at 1.24%, up from 2.39% in the prior quarter.
- The five-year high for Return on Sales was 0.42% in Q4 2024, with the low at 12.93% in Q4 2022.
- A 5-year average of 1.83% and a median of 0.44% in 2024 frame the typical range for Return on Sales.
- Across the five-year window, Return on Sales sank 1242 bps in 2022 and surged 1189 bps in 2023, its largest moves.
- Lyra Therapeutics' Return on Sales stood at 0.51% in 2021, then plunged by 2459 bps to 12.93% in 2022, then jumped by 92 bps to 1.04% in 2023, then soared by 140 bps to 0.42% in 2024, then slumped by 399 bps to 1.24% in 2025.
- The last three Return on Sales figures came in at 1.24% (Q4 2025), 2.39% (Q3 2025), and 0.41% (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn | 0.00% |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn | 0.00% |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn | 0.00% |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn | -0.05% |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn | 0.00% |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn | 0.00% |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn | 0.00% |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn | 0.00% |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - | 0.00% |
| 10 | Lyra Therapeutics | 70,995.28 | 70,995.28 | - | -1.24% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -1.24% |
| Sep 30, 2025 | -2.39% |
| Jun 30, 2025 | -0.41% |
| Mar 31, 2025 | -0.47% |
| Dec 31, 2024 | 0.42% |
| Sep 30, 2024 | -0.61% |
| Jun 30, 2024 | -0.80% |
| Mar 31, 2024 | -0.42% |
| Dec 31, 2023 | -1.04% |
| Sep 30, 2023 | -0.29% |
| Jun 30, 2023 | -0.34% |
| Mar 31, 2023 | -0.40% |
| Dec 31, 2022 | -12.93% |
| Sep 30, 2022 | -0.41% |
| Jun 30, 2022 | -0.27% |
| Mar 31, 2022 | -0.25% |
| Dec 31, 2021 | -0.51% |
| Sep 30, 2021 | -10.57% |