Lyra Therapeutics (LYRA) Return on Sales (2021 - 2025)
Quarterly Return on Sales fell 940.0% to 9.93% in Q4 2025 from the year-ago period, while the trailing twelve-month figure was 0.73% through Dec 2025, down 12.0% year-over-year, with the annual reading at 0.73% for FY2025, 12.0% down from the prior year.
Lyra Therapeutics' Return on Sales history spans 5 years, with the latest figure at 9.93% for Q4 2025.
- Return on Sales came in at 9.93% for Q4 2025, down from 2.39% in the prior quarter.
- In the past five years, Return on Sales ranged from a high of 0.25% in Q1 2022 to a low of 12.93% in Q4 2022.
- The 5-year median for Return on Sales is 0.48% (2021), against an average of 2.22%.
- Year-over-year, Return on Sales crashed -1243bps in 2022 and then surged 1189bps in 2023.
- Lyra Therapeutics' Return on Sales stood at 0.5% in 2021, then plummeted by -2473bps to 12.93% in 2022, then surged by 92bps to 1.04% in 2023, then surged by 49bps to 0.53% in 2024, then crashed by -1790bps to 9.93% in 2025.
- Per Business Quant, the three most recent readings for LYRA's Return on Sales are 9.93% (Q4 2025), 2.39% (Q3 2025), and 0.41% (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | - |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | 0.00% |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 0.00% |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 0.00% |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | 0.00% |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 0.00% |
| 10 | Lyra Therapeutics | - | - | - | -9.93% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -9.93% |
| Sep 30, 2025 | -2.39% |
| Jun 30, 2025 | -0.41% |
| Mar 31, 2025 | -0.47% |
| Dec 31, 2024 | -0.53% |
| Sep 30, 2024 | -0.61% |
| Jun 30, 2024 | -0.80% |
| Mar 31, 2024 | -0.42% |
| Dec 31, 2023 | -1.04% |
| Sep 30, 2023 | -0.29% |
| Jun 30, 2023 | -0.34% |
| Mar 31, 2023 | -0.40% |
| Dec 31, 2022 | -12.93% |
| Sep 30, 2022 | -0.41% |
| Jun 30, 2022 | -0.27% |
| Mar 31, 2022 | -0.25% |
| Dec 31, 2021 | -0.50% |
| Sep 30, 2021 | -7.90% |