Lyra Therapeutics (LYRA) Operating Expenses (2019 - 2025)
Quarterly Operating Expenses fell 38.67% to $7.1 million in Q4 2025 from the year-ago period, while the trailing twelve-month figure was $31.4 million through Dec 2025, down 67.9% year-over-year, with the annual reading at $31.4 million for FY2025, 67.9% down from the prior year.
Lyra Therapeutics' Operating Expenses history spans 7 years, with the latest figure at $7.1 million for Q4 2025.
- Operating Expenses came in at $7.1 million for Q4 2025, up from $6.3 million in the prior quarter.
- In the past five years, Operating Expenses ranged from a high of $49.6 million in Q2 2024 to a low of $6.3 million in Q3 2025.
- The 5-year median for Operating Expenses is $13.3 million (2021), against an average of $15.0 million.
- Year-over-year, Operating Expenses soared 192.27% in 2024 and then plummeted 81.83% in 2025.
- Lyra Therapeutics' Operating Expenses stood at $13.9 million in 2021, then rose by 9.04% to $15.2 million in 2022, then increased by 9.61% to $16.6 million in 2023, then plummeted by 30.11% to $11.6 million in 2024, then plummeted by 38.67% to $7.1 million in 2025.
- Per Business Quant, the three most recent readings for LYRA's Operating Expenses are $7.1 million (Q4 2025), $6.3 million (Q3 2025), and $9.0 million (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | 2.97 Mn |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | 4.33 Mn |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | -138.30 Mn |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | 15.76 Mn |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 1.85 Bn |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 2.96 Bn |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | -3.82 Mn |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 898.54 Mn |
| 10 | Lyra Therapeutics | - | - | - | 7.13 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 7.13 Mn |
| Sep 30, 2025 | 6.26 Mn |
| Jun 30, 2025 | 9.01 Mn |
| Mar 31, 2025 | 9.02 Mn |
| Dec 31, 2024 | 11.62 Mn |
| Sep 30, 2024 | 12.64 Mn |
| Jun 30, 2024 | 49.57 Mn |
| Mar 31, 2024 | 24.06 Mn |
| Dec 31, 2023 | 16.62 Mn |
| Sep 30, 2023 | 17.37 Mn |
| Jun 30, 2023 | 16.96 Mn |
| Mar 31, 2023 | 17.72 Mn |
| Dec 31, 2022 | 15.17 Mn |
| Sep 30, 2022 | 15.19 Mn |
| Jun 30, 2022 | 14.93 Mn |
| Mar 31, 2022 | 12.39 Mn |
| Dec 31, 2021 | 13.91 Mn |
| Sep 30, 2021 | 11.10 Mn |
| Jun 30, 2021 | 11.07 Mn |
| Mar 31, 2021 | 7.83 Mn |
| Dec 31, 2020 | 7.05 Mn |
| Sep 30, 2020 | 6.36 Mn |
| Jun 30, 2020 | 4.55 Mn |
| Mar 31, 2020 | 4.25 Mn |
| Dec 31, 2019 | 4.39 Mn |
| Sep 30, 2019 | 4.23 Mn |
| Jun 30, 2019 | 4.28 Mn |
| Mar 31, 2019 | 3.62 Mn |