Lyra Therapeutics (LYRA) Enterprise Value (2019 - 2025)
Quarterly Enterprise Value rose 60.83% to -$15.9 million in Q4 2025 from the year-ago period, while the trailing twelve-month figure was -$15.9 million through Dec 2025, up 60.83% year-over-year, with the annual reading at -$15.9 million for FY2025, 60.83% up from the prior year.
Lyra Therapeutics' Enterprise Value history spans 7 years, with the latest figure at -$15.9 million for Q4 2025.
- Enterprise Value came in at -$15.9 million for Q4 2025, up from -$22.1 million in the prior quarter.
- In the past five years, Enterprise Value ranged from a high of -$15.9 million in Q4 2025 to a low of -$122.4 million in Q2 2022.
- The 5-year median for Enterprise Value is -$69.3 million (2021), against an average of -$66.9 million.
- Year-over-year, Enterprise Value tumbled 146.78% in 2023 and then soared 64.38% in 2025.
- Lyra Therapeutics' Enterprise Value stood at -$46.1 million in 2021, then crashed by 115.48% to -$99.3 million in 2022, then fell by 4.89% to -$104.1 million in 2023, then soared by 61.04% to -$40.6 million in 2024, then surged by 60.83% to -$15.9 million in 2025.
- Per Business Quant, the three most recent readings for LYRA's Enterprise Value are -$15.9 million (Q4 2025), -$22.1 million (Q3 2025), and -$29.8 million (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Enterprise Value (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | -2.32 Mn |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | -32.30 Mn |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | -901.90 Mn |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | -61.46 Mn |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | -2.77 Mn |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | -7.25 Bn |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | -8.75 Bn |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | -18.44 Mn |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | -3.01 Bn |
| 10 | Lyra Therapeutics | - | - | - | -15.89 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -15.89 Mn |
| Sep 30, 2025 | -22.06 Mn |
| Jun 30, 2025 | -29.78 Mn |
| Mar 31, 2025 | -31.74 Mn |
| Dec 31, 2024 | -40.58 Mn |
| Sep 30, 2024 | -53.62 Mn |
| Jun 30, 2024 | -69.50 Mn |
| Mar 31, 2024 | -89.09 Mn |
| Dec 31, 2023 | -104.15 Mn |
| Sep 30, 2023 | -103.94 Mn |
| Jun 30, 2023 | -78.42 Mn |
| Mar 31, 2023 | -84.11 Mn |
| Dec 31, 2022 | -99.29 Mn |
| Sep 30, 2022 | -111.31 Mn |
| Jun 30, 2022 | -122.42 Mn |
| Mar 31, 2022 | -34.08 Mn |
| Dec 31, 2021 | -46.08 Mn |
| Jun 30, 2021 | -69.05 Mn |
| Dec 31, 2020 | -74.92 Mn |
| Jun 30, 2020 | -86.60 Mn |
| Mar 31, 2020 | -35.25 Mn |
| Dec 31, 2019 | -9.81 Mn |