Lyra Therapeutics (LYRA) FCF Margin (2021 - 2025)
Lyra Therapeutics (LYRA) recorded FCF Margin of -88028.57% in Q4 2025, down 82624.74 percentage points from -5403.83% a year earlier and down 58584.57 percentage points from the prior quarter.
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Analysis
Lyra Therapeutics (LYRA) FCF Margin (2021 - 2025) Analysis & Trends
For FY2025, Lyra Therapeutics reported FCF Margin of -7280.15%, down 2563.79 percentage points from FY2024.
- Annual FCF Margin has declined for three straight years, though with a four-year change of +2967.22 percentage points (FY2021 to FY2025).
- Across earlier years, FCF Margin came in at -4716.36% in FY2024 (-586.00 pp), -4130.36% in FY2023 (-935.28 pp), -3195.08% in FY2022 (+7052.28 pp) and -10247.37% in FY2021.
- The Q4 2025 figure is the lowest quarterly FCF Margin since Q4 2022.
- On a year-over-year basis, FCF Margin has declined for four consecutive quarters, with an average year-over-year change of -12835.16 percentage points over the last eight quarters.
- Peak year-over-year performance for FCF Margin in the last five years was a gain of 97243.90 percentage points in Q4 2023, against a drop of 106268.10 percentage points in Q4 2022 at the low end.
- Per Business Quant, the preceding three quarters came in at -29444.00% (Q3 2025), -3601.09% (Q2 2025) and -4831.69% (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 645.01 Bn | 563.54 Bn | 17.26 Bn | 28.82% |
| 2 | AbbVie | 465.23 Bn | 438.39 Bn | 12.70 Bn | 18.33% |
| 3 | Merck | 368.40 Bn | 322.83 Bn | 12.21 Bn | 26.96% |
| 4 | Novartis Ag | 278.02 Bn | 233.89 Bn | 11.24 Bn | 43.05% |
| 5 | Astrazeneca | 254.57 Bn | 228.13 Bn | 12.86 Bn | 34.72% |
| 6 | Amgen | 229.02 Bn | 184.42 Bn | 7.24 Bn | 34.70% |
| 7 | Gilead Sciences | 187.74 Bn | 161.85 Bn | 6.22 Bn | 44.00% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 2.01% |
| 9 | Vertex Pharmaceuticals | 133.45 Bn | 105.45 Bn | 2.84 Bn | 30.39% |
| 10 | Lyra Therapeutics | 354,976.41 | 354,976.41 | - | -88,028.57% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -88,028.57% |
| Sep 30, 2025 | -29,444.00% |
| Jun 30, 2025 | -3,601.09% |
| Mar 31, 2025 | -4,831.69% |
| Dec 31, 2024 | -5,403.83% |
| Sep 30, 2024 | -8,345.64% |
| Jun 30, 2024 | -3,374.08% |
| Mar 31, 2024 | -4,624.81% |
| Dec 31, 2023 | -13,592.47% |
| Sep 30, 2023 | -2,620.96% |
| Jun 30, 2023 | -3,133.84% |
| Mar 31, 2023 | -3,876.83% |
| Dec 31, 2022 | -110,836.36% |
| Sep 30, 2022 | -3,029.25% |
| Jun 30, 2022 | -1,616.00% |
| Mar 31, 2022 | -2,563.68% |
| Dec 31, 2021 | -4,568.27% |
| Sep 30, 2021 | -77,364.29% |
API Access
Lyra Therapeutics FCF Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=fcf-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "fcf-margin", "ticker": "LYRA", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=fcf-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEY");
const data = await res.json();