Lyra Therapeutics (LYRA) FCF Margin (2021 - 2025)
Lyra Therapeutics (LYRA) posted FCF Margin of 87357.14% for Q4 2025, down 194.81% on a QoQ basis from 29632.0% in Q3 2025, and down 8195332.0% year-over-year from N/an in Q4 2024.
Analysis
Lyra Therapeutics (LYRA) FCF Margin (2021 - 2025) Analysis & Trends
Lyra Therapeutics has reported FCF Margin for 5 years, with the latest figure at 87357.14% in Q4 2025.
- On a quarterly basis, FCF Margin fell 8195332.0% year-over-year to 87357.14% in Q4 2025; TTM through Dec 2025 was 7275.13%, a 255876.0% decrease from a year earlier, with the FY2025 full-year figure at 7280.15%, down 256379.0% from the prior year.
- FCF Margin was 87357.14% for Q4 2025 at Lyra Therapeutics, down from 29632.0% in the prior quarter.
- The five-year high for FCF Margin was 1616.0% in Q2 2022, with the low at 110836.36% in Q4 2022.
- Average FCF Margin over 5 years is 20576.23%, with a median of 4596.54% recorded in 2021.
- The sharpest annual moves came in 2022 and 2023: FCF Margin tumbled 10626810 bps in 2022, then jumped 9724390 bps in 2023.
- Over 5 years, FCF Margin stood at 4568.27% in 2021, then plunged by 2326 bps to 110836.36% in 2022, then jumped by 88 bps to 13592.47% in 2023, then surged by 60 bps to 5403.83% in 2024, then sank by 1517 bps to 87357.14% in 2025.
- The last three FCF Margin figures came in at 87357.14% (Q4 2025), 29632.0% (Q3 2025), and 3601.09% (Q2 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Amgen | 206.44 Bn | 192.45 Bn | 7.24 Bn | 34.70% |
| 2 | Gilead Sciences | 179.97 Bn | 176.79 Bn | 6.22 Bn | 44.00% |
| 3 | Vertex Pharmaceuticals | 130.57 Bn | 122.72 Bn | 2.84 Bn | 30.39% |
| 4 | Regeneron Pharmaceuticals | 81.63 Bn | 73.63 Bn | 3.93 Bn | 13.35% |
| 5 | Argenx Se | 60.34 Bn | 55.16 Bn | 1.37 Bn | - |
| 6 | Moderna | 54.37 Bn | 49.23 Bn | 52.00 Mn | -388.28% |
| 7 | Alnylam Pharmaceuticals | 33.07 Bn | 29.76 Bn | 992.69 Mn | 22.62% |
| 8 | Biogen | 31.84 Bn | 30.55 Bn | 1.96 Bn | 14.91% |
| 9 | Roivant Sciences | 29.49 Bn | 29.49 Bn | 1.16 Mn | -18,629.40% |
| 10 | Lyra Therapeutics | 354,976.41 | 354,976.41 | - | -87,357.14% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -87,357.14% |
| Sep 30, 2025 | -29,632.00% |
| Jun 30, 2025 | -3,601.09% |
| Mar 31, 2025 | -4,831.69% |
| Dec 31, 2024 | -5,403.83% |
| Sep 30, 2024 | -8,345.64% |
| Jun 30, 2024 | -3,374.08% |
| Mar 31, 2024 | -4,624.81% |
| Dec 31, 2023 | -13,592.47% |
| Sep 30, 2023 | -2,620.96% |
| Jun 30, 2023 | -3,133.84% |
| Mar 31, 2023 | -3,876.83% |
| Dec 31, 2022 | -110,836.36% |
| Sep 30, 2022 | -3,029.25% |
| Jun 30, 2022 | -1,616.00% |
| Mar 31, 2022 | -2,563.68% |
| Dec 31, 2021 | -4,568.27% |
| Sep 30, 2021 | -77,364.29% |