Lyra Therapeutics LYRA
LYRA
$0.19 +0.00 (+0.00%)
At close: Sep 8, 2026 · 4:00 PM EDT

Lyra Therapeutics (LYRA) FCF Margin (2021 - 2025)

Lyra Therapeutics (LYRA) posted FCF Margin of 87357.14% for Q4 2025, down 194.81% on a QoQ basis from 29632.0% in Q3 2025, and down 8195332.0% year-over-year from N/an in Q4 2024.

Analysis

Lyra Therapeutics (LYRA) FCF Margin (2021 - 2025) Analysis & Trends

Lyra Therapeutics has reported FCF Margin for 5 years, with the latest figure at 87357.14% in Q4 2025.

  • On a quarterly basis, FCF Margin fell 8195332.0% year-over-year to 87357.14% in Q4 2025; TTM through Dec 2025 was 7275.13%, a 255876.0% decrease from a year earlier, with the FY2025 full-year figure at 7280.15%, down 256379.0% from the prior year.
  • FCF Margin was 87357.14% for Q4 2025 at Lyra Therapeutics, down from 29632.0% in the prior quarter.
  • The five-year high for FCF Margin was 1616.0% in Q2 2022, with the low at 110836.36% in Q4 2022.
  • Average FCF Margin over 5 years is 20576.23%, with a median of 4596.54% recorded in 2021.
  • The sharpest annual moves came in 2022 and 2023: FCF Margin tumbled 10626810 bps in 2022, then jumped 9724390 bps in 2023.
  • Over 5 years, FCF Margin stood at 4568.27% in 2021, then plunged by 2326 bps to 110836.36% in 2022, then jumped by 88 bps to 13592.47% in 2023, then surged by 60 bps to 5403.83% in 2024, then sank by 1517 bps to 87357.14% in 2025.
  • The last three FCF Margin figures came in at 87357.14% (Q4 2025), 29632.0% (Q3 2025), and 3601.09% (Q2 2025), per Business Quant data.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) FCF Margin (Qtr)
1 Amgen 206.44 Bn 192.45 Bn 7.24 Bn 34.70%
2 Gilead Sciences 179.97 Bn 176.79 Bn 6.22 Bn 44.00%
3 Vertex Pharmaceuticals 130.57 Bn 122.72 Bn 2.84 Bn 30.39%
4 Regeneron Pharmaceuticals 81.63 Bn 73.63 Bn 3.93 Bn 13.35%
5 Argenx Se 60.34 Bn 55.16 Bn 1.37 Bn -
6 Moderna 54.37 Bn 49.23 Bn 52.00 Mn -388.28%
7 Alnylam Pharmaceuticals 33.07 Bn 29.76 Bn 992.69 Mn 22.62%
8 Biogen 31.84 Bn 30.55 Bn 1.96 Bn 14.91%
9 Roivant Sciences 29.49 Bn 29.49 Bn 1.16 Mn -18,629.40%
10 Lyra Therapeutics 354,976.41 354,976.41 - -87,357.14%
Historic Data

Historic Data

Download Data
DateValue
Dec 31, 2025 -87,357.14%
Sep 30, 2025 -29,632.00%
Jun 30, 2025 -3,601.09%
Mar 31, 2025 -4,831.69%
Dec 31, 2024 -5,403.83%
Sep 30, 2024 -8,345.64%
Jun 30, 2024 -3,374.08%
Mar 31, 2024 -4,624.81%
Dec 31, 2023 -13,592.47%
Sep 30, 2023 -2,620.96%
Jun 30, 2023 -3,133.84%
Mar 31, 2023 -3,876.83%
Dec 31, 2022 -110,836.36%
Sep 30, 2022 -3,029.25%
Jun 30, 2022 -1,616.00%
Mar 31, 2022 -2,563.68%
Dec 31, 2021 -4,568.27%
Sep 30, 2021 -77,364.29%