Lyra Therapeutics (LYRA) FCF Margin (2021 - 2025)
Quarterly FCF Margin fell 8262474.0% to 88028.57% in Q4 2025 from the year-ago period, while the trailing twelve-month figure was 7275.13% through Dec 2025, down 255876.0% year-over-year, with the annual reading at 7280.15% for FY2025, 256379.0% down from the prior year.
Lyra Therapeutics' FCF Margin history spans 5 years, with the latest figure at 88028.57% for Q4 2025.
- FCF Margin came in at 88028.57% for Q4 2025, down from 29444.0% in the prior quarter.
- In the past five years, FCF Margin ranged from a high of 1596.76% in Q2 2022 to a low of 110836.36% in Q4 2022.
- The 5-year median for FCF Margin is 4559.17% (2024), against an average of 20164.65%.
- Year-over-year, FCF Margin tumbled -10580574bps in 2022 and then surged 9736171bps in 2023.
- Lyra Therapeutics' FCF Margin stood at 5030.63% in 2021, then tumbled by -2103bps to 110836.36% in 2022, then soared by 88bps to 13474.66% in 2023, then soared by 60bps to 5403.83% in 2024, then tumbled by -1529bps to 88028.57% in 2025.
- Per Business Quant, the three most recent readings for LYRA's FCF Margin are 88028.57% (Q4 2025), 29444.0% (Q3 2025), and 3601.09% (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | - |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | -3.98% |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 43.35% |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 23.53% |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | - |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 4.17% |
| 10 | Lyra Therapeutics | - | - | - | -88,028.57% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -88,028.57% |
| Sep 30, 2025 | -29,444.00% |
| Jun 30, 2025 | -3,601.09% |
| Mar 31, 2025 | -4,831.69% |
| Dec 31, 2024 | -5,403.83% |
| Sep 30, 2024 | -9,515.38% |
| Jun 30, 2024 | -3,293.48% |
| Mar 31, 2024 | -4,286.65% |
| Dec 31, 2023 | -13,474.66% |
| Sep 30, 2023 | -2,574.63% |
| Jun 30, 2023 | -3,133.84% |
| Mar 31, 2023 | -3,876.83% |
| Dec 31, 2022 | -110,836.36% |
| Sep 30, 2022 | -3,057.38% |
| Jun 30, 2022 | -1,596.76% |
| Mar 31, 2022 | -2,563.68% |
| Dec 31, 2021 | -5,030.63% |
| Sep 30, 2021 | -68,414.29% |