Lyra Therapeutics, Inc. (LYRA) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

266,083Shares Outstanding

91,645Shares held by institutions

$123,720Value of institutional holdings

52.47%Institutional ownership %

-3.16%Shares Changed QoQ

47No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Lyra Therapeutics, Inc. (NASDAQ:LYRA) currently has 22 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

The collective stake of institutional investors in Lyra Therapeutics moved to 15.7% in December 2025, a shift down from the 31.8% reported for September 2025.
Institutional share ownership changed by 48.69% QoQ, while the number of institutional owners saw a decrease of 60.00% YoY.
The latest 13F cycle for Lyra Therapeutics reveals that of 22 total investors, 9 funds grew their exposure, whereas 7 reduced theirs and 6 made no changes.
This class of investors increased its holdings in Lyra Therapeutics to 221.48K shares for the 13F-cycle ending December 2025, up by 72.53K shares quarter on quarter, and down 315.95K shares year over year.
The top institutional stake in Lyra Therapeutics as of December 31, 2025 belongs to SABBY MANAGEMENT, LLC, which owns 175.16K shares, or 12.43% of the company.
Among the most significant buyers of Lyra Therapeutics during December 2025 were SABBY MANAGEMENT, LLC (47.53K), DRW Securities, LLC (16.81K), Artia Global Partners LP (8.76K), Tower Research Capital LLC (TRC) (1.66K), GEODE CAPITAL MANAGEMENT, LLC (1.26K).
Leading sellers of Lyra Therapeutics stock in December 2025 included UBS Group AG (3.33K), MORGAN STANLEY (943), CITIGROUP INC (702), CWM, LLC (23), Wilmington Savings Fund Society, FSB (20).
The top 10 institutional holders of Lyra Therapeutics for the quarter ending December 2025 included SABBY MANAGEMENT, LLC (175.16K), DRW Securities, LLC (16.81K), GEODE CAPITAL MANAGEMENT, LLC (12.25K), Artia Global Partners LP (8.76K), BlackRock, Inc. (2.39K), Tower Research Capital LLC (TRC) (2.19K), ROYAL BANK OF CANADA (1.95K), UBS Group AG (675), EverSource Wealth Advisors, LLC (338), MORGAN STANLEY (334).

22 Institutional Holders

91,645 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
SABBY MANAGEMENT, LLC	31 Dec, 2025	175,158	47,534	37.25%	$539,487.00
DRW Securities, LLC	31 Dec, 2025	16,812	16,812	0.00%	$51,780.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	12,249	1,263	11.50%	$37,733.00
Artia Global Partners LP	31 Dec, 2025	8,756	8,756	0.00%	$26,968.00
BlackRock, Inc.	31 Dec, 2025	2,394	704	41.66%	$7,373.00
Tower Research Capital LLC (TRC)	31 Dec, 2025	2,191	1,657	310.30%	$6,748.00
ROYAL BANK OF CANADA	31 Dec, 2025	1,953	628	47.40%	$6,000.00
UBS Group AG	31 Dec, 2025	675	-3,326	-83.13%	$2,079.00
EverSource Wealth Advisors, LLC	31 Dec, 2025	338	-7	-2.03%	$1,041.00
MORGAN STANLEY	31 Dec, 2025	334	-943	-73.84%	$1,029.00
JONES FINANCIAL COMPANIES LLLP	31 Dec, 2025	210	0	0.00%	$647.00
BANK OF AMERICA CORP /DE/	31 Dec, 2025	201	183	1,016.67%	$619.00
SBI Securities Co., Ltd.	31 Dec, 2025	80	0	0.00%	$246.00
JPMORGAN CHASE & CO	31 Dec, 2025	27	0	0.00%	$83.00
COMERICA BANK	31 Dec, 2025	23	0	0.00%	$71.00
OSAIC HOLDINGS, INC.	31 Dec, 2025	22	0	0.00%	$67.00
Wilmington Savings Fund Society, FSB	31 Dec, 2025	20	-20	-50.00%	$62.00
BNP PARIBAS FINANCIAL MARKETS	31 Dec, 2025	16	0	0.00%	$49.00
Global Retirement Partners, LLC	31 Dec, 2025	15	15	0.00%	$46.00
CITIGROUP INC	31 Dec, 2025	3	-702	-99.57%	$9.00

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