Lyra Therapeutics (LYRA) Operating Margin (2021 - 2025)
Quarterly Operating Margin fell 9622734.0% to 101685.71% in Q4 2025 from the year-ago period, while the trailing twelve-month figure was 7794.47% through Dec 2025, down 151364.0% year-over-year, with the annual reading at 7794.47% for FY2025, 151364.0% down from the prior year.
Lyra Therapeutics' Operating Margin history spans 5 years, with the latest figure at 101685.71% for Q4 2025.
- Operating Margin came in at 101685.71% for Q4 2025, down from 24948.0% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 2548.08% in Q1 2022 to a low of 137772.73% in Q4 2022.
- The 5-year median for Operating Margin is 4931.81% (2025), against an average of 23017.71%.
- Year-over-year, Operating Margin tumbled -13274025bps in 2022 and then soared 12648711bps in 2023.
- Lyra Therapeutics' Operating Margin stood at 5032.47% in 2021, then crashed by -2638bps to 137772.73% in 2022, then soared by 92bps to 11285.62% in 2023, then soared by 52bps to 5458.37% in 2024, then plummeted by -1763bps to 101685.71% in 2025.
- Per Business Quant, the three most recent readings for LYRA's Operating Margin are 101685.71% (Q4 2025), 24948.0% (Q3 2025), and 4822.95% (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | - |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | -6.43% |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 38.10% |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 17.83% |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | - |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 23.02% |
| 10 | Lyra Therapeutics | - | - | - | -101,685.71% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -101,685.71% |
| Sep 30, 2025 | -24,948.00% |
| Jun 30, 2025 | -4,822.95% |
| Mar 31, 2025 | -4,831.15% |
| Dec 31, 2024 | -5,458.37% |
| Sep 30, 2024 | -6,380.51% |
| Jun 30, 2024 | -8,189.63% |
| Mar 31, 2024 | -4,421.80% |
| Dec 31, 2023 | -11,285.62% |
| Sep 30, 2023 | -3,093.20% |
| Jun 30, 2023 | -3,603.28% |
| Mar 31, 2023 | -4,222.68% |
| Dec 31, 2022 | -137,772.73% |
| Sep 30, 2022 | -4,129.81% |
| Jun 30, 2022 | -2,742.86% |
| Mar 31, 2022 | -2,548.08% |
| Dec 31, 2021 | -5,032.47% |
| Sep 30, 2021 | -79,150.00% |