Axsome Therapeutics (AXSM) EBITDA Margin (2022 - 2026)
Axsome Therapeutics (AXSM) recorded EBITDA Margin of -21.48% in Q2 2026, up 1.57 percentage points from -23.05% a year earlier and up 10.48 percentage points from the prior quarter.
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Analysis
Axsome Therapeutics (AXSM) EBITDA Margin (2022 - 2026) Analysis & Trends
On a TTM basis, Axsome Therapeutics' EBITDA Margin came in at -22.74% as of Jun 30, 2026, up 21.89 percentage points year-over-year; for FY2025, it came in at -24.78%, up 46.04 percentage points from FY2024.
- Annual EBITDA Margin has increased for three straight years, with a three-year change of +325.76 percentage points (FY2022 to FY2025).
- Across earlier years, EBITDA Margin came in at -70.82% in FY2024 (+12.33 pp), -83.15% in FY2023 (+267.39 pp) and -350.53% in FY2022.
- Quarterly EBITDA Margin has ranged from -432.97% in Q2 2022 to -4.95% in Q1 2023 over the past five years.
- On a year-over-year basis, EBITDA Margin has increased for nine consecutive quarters, with an average year-over-year change of +40.32 percentage points over the last eight quarters.
- Peak year-over-year performance for EBITDA Margin in the last five years was a gain of 297.28 percentage points in Q2 2023, against a drop of 82.45 percentage points in Q1 2024 at the low end.
- Per Business Quant, the preceding three quarters came in at -31.96% (Q1 2026), -12.65% (Q4 2025) and -25.63% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 35.95% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 49.01% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | 6.02% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | - |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 33.11% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 46.01% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -124.26% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 39.16% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 39.10% |
| 10 | Axsome Therapeutics | 10.14 Bn | 8.87 Bn | 204.81 Mn | -21.48% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -21.48% |
| Mar 31, 2026 | -31.96% |
| Dec 31, 2025 | -12.65% |
| Sep 30, 2025 | -25.63% |
| Jun 30, 2025 | -23.05% |
| Mar 31, 2025 | -45.28% |
| Dec 31, 2024 | -59.51% |
| Sep 30, 2024 | -57.94% |
| Jun 30, 2024 | -87.41% |
| Mar 31, 2024 | -87.41% |
| Dec 31, 2023 | -134.96% |
| Sep 30, 2023 | -104.47% |
| Jun 30, 2023 | -135.69% |
| Mar 31, 2023 | -4.95% |
| Dec 31, 2022 | -238.92% |
| Sep 30, 2022 | -241.78% |
| Jun 30, 2022 | -432.97% |
API Access
Axsome Therapeutics EBITDA Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebitda-margin&ticker=AXSM&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebitda-margin", "ticker": "AXSM", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebitda-margin&ticker=AXSM&period=max&api_key=YOUR_API_KEY");
const data = await res.json();