Axsome Therapeutics (AXSM) Operating Margin (2022 - 2026)
Axsome Therapeutics' Operating Margin was -22.73% in Q2 2026, up 1.73 percentage points from -24.47% a year earlier and up 10.40 percentage points from the prior quarter.
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Analysis
Axsome Therapeutics (AXSM) Operating Margin (2022 - 2026) Analysis & Trends
On a trailing twelve-month basis, Axsome Therapeutics' Operating Margin was -23.96% through Jun 30, 2026, up 22.29 percentage points year-over-year; for FY2025, it came in at -26.12%, up 46.62 percentage points from FY2024.
- Operating Margin has now increased for three consecutive years, with a three-year change of +333.21 percentage points (FY2022 to FY2025).
- In earlier years, Operating Margin was -72.74% in FY2024 (+12.93 pp), -85.67% in FY2023 (+273.66 pp) and -359.33% in FY2022.
- Quarterly Operating Margin has moved between -444.23% (Q2 2022) and -6.74% (Q1 2023) over five years.
- Compared with a year earlier, Operating Margin has increased for nine straight quarters, with an average year-over-year change of +40.94 percentage points over the last eight quarters.
- The best year-over-year quarter for Operating Margin over five years was Q2 2023 (a gain of 304.92 percentage points); the worst was Q1 2024 (a drop of 82.96 percentage points).
- Per Business Quant data, AXSM's Operating Margin in the three quarters before Q2 2026 was -33.14% (Q1 2026), -13.75% (Q4 2025) and -26.97% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Axsome Therapeutics | 10.14 Bn | 8.87 Bn | 204.81 Mn | -22.73% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -22.73% |
| Mar 31, 2026 | -33.14% |
| Dec 31, 2025 | -13.75% |
| Sep 30, 2025 | -26.97% |
| Jun 30, 2025 | -24.47% |
| Mar 31, 2025 | -46.91% |
| Dec 31, 2024 | -61.14% |
| Sep 30, 2024 | -59.78% |
| Jun 30, 2024 | -89.54% |
| Mar 31, 2024 | -89.70% |
| Dec 31, 2023 | -137.39% |
| Sep 30, 2023 | -107.49% |
| Jun 30, 2023 | -139.31% |
| Mar 31, 2023 | -6.74% |
| Dec 31, 2022 | -245.86% |
| Sep 30, 2022 | -251.76% |
| Jun 30, 2022 | -444.23% |
API Access
Axsome Therapeutics Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=AXSM&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "AXSM", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=AXSM&period=max&api_key=YOUR_API_KEY");
const data = await res.json();