Axsome Therapeutics (AXSM) Return on Capital Employed (2016 - 2026)

Axsome Therapeutics' (AXSM) quarterly Return on Capital Employed came in at 17.09% in Q1 2026, up 6272.0% year-on-year from 0.27% in Q1 2025, and down 33.53% quarter-over-quarter from 12.8% in Q4 2025.

Axsome Therapeutics (AXSM) Return on Capital Employed (2016 - 2026) Analysis & Trends

Axsome Therapeutics has disclosed Return on Capital Employed across 11 years of filings, most recently posting 17.09% for Q1 2026.

  • Return on Capital Employed for Q1 2026 came in at 17.09%, up 6272.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 17.09% (up 6272.0% YoY), and the FY2025 annual result was 15.37%, up 6519.0% from the prior year.
  • Return on Capital Employed came in at 17.09% for Q1 2026 at Axsome Therapeutics, down from 12.8% in the prior quarter.
  • In the past five years, Return on Capital Employed ranged from a high of 12.8% in Q4 2025 to a low of 212.43% in Q1 2022.
  • The 5-year median for Return on Capital Employed is 75.34% (2022), against an average of 76.5%.
  • Across the five-year window, Return on Capital Employed plunged 15140 bps in 2022 and surged 15548 bps in 2023, its largest moves.
  • Axsome Therapeutics' Return on Capital Employed stood at 75.34% in 2022, then surged by 32 bps to 50.87% in 2023, then slumped by 65 bps to 83.78% in 2024, then soared by 85 bps to 12.8% in 2025, then plunged by 34 bps to 17.09% in 2026.
  • The last three Return on Capital Employed figures came in at 17.09% (Q1 2026), 12.8% (Q4 2025), and 72.2% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 450.31%
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 51.73%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -107.40%
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 21.10%
9 Abivax 91.96 Bn 91.96 Bn - -50.43%
10 Axsome Therapeutics 12.84 Bn 12.54 Bn 176.48 Mn -17.09%

Historic Data

Download Data
DateValue
Mar 31, 2026 -17.09%
Dec 31, 2025 -12.80%
Sep 30, 2025 -72.20%
Jun 30, 2025 -82.91%
Mar 31, 2025 -79.80%
Dec 31, 2024 -83.78%
Sep 30, 2024 -85.38%
Jun 30, 2024 -84.82%
Mar 31, 2024 -69.21%
Dec 31, 2023 -50.87%
Sep 30, 2023 -39.36%
Jun 30, 2023 -45.08%
Mar 31, 2023 -56.95%
Dec 31, 2022 -75.34%
Sep 30, 2022 -76.45%
Jun 30, 2022 -155.98%
Mar 31, 2022 -212.43%
Dec 31, 2021 -157.60%
Sep 30, 2021 -113.89%
Jun 30, 2021 -81.35%