Axsome Therapeutics, Inc. (AXSM) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

50,021,851Shares Outstanding

36,885,745Shares held by institutions

$6,777,940,072Value of institutional holdings

73.74%Institutional ownership %

6.58%Shares Changed QoQ

388No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Axsome Therapeutics, Inc. (NASDAQ:AXSM) has 388 institutional investors with active 13F positions as of December 2025.

They owned 73.1% of outstanding stock in December 2025, down from 75.8% the prior quarter.
Their total shares held in AXSM increased 6.06% from the prior quarter, while the number of investors in Axsome Therapeutics increased 34.72% year over year.
Among the 388 funds, 218 bought more Axsome Therapeutics shares, 121 sold down, and 49 held their ground.
The aggregate institutional position in Axsome Therapeutics amounted to 36.56Mn shares as of December 2025, up by 2.09Mn shares quarter on quarter, and down 2.17Mn shares year over year.
VANGUARD GROUP INC is the top holder of Axsome Therapeutics as of December 31, 2025, with 4.16Mn shares representing 8.33% of outstanding stock.
Top purchasers of AXSM stock for the quarter ending December 2025 included NOMURA ASSET MANAGEMENT INTERNATIONAL INC. (989.45K), NORGES BANK (495.46K), Rockefeller Capital Management L.P. (419.86K), Goldman Sachs Group Inc (377.67K), Invesco Ltd. (282.94K).
The largest sales of AXSM for the quarter ending December 2025 came from BVF INC/IL (441.0K), Sofinnova Investments, Inc. (381.23K), PFM Health Sciences, LP (278.77K), ORBIMED ADVISORS LLC (278.68K), Jpmorgan Chase & Co (267.83K).
Per Business Quant, the top 10 investors in AXSM for the quarter ending December 2025 include VANGUARD GROUP INC (4.16Mn), BlackRock, Inc. (3.91Mn), Invesco Ltd. (1.27Mn), WELLINGTON MANAGEMENT GROUP LLP (1.22Mn), FMR LLC (1.18Mn), Deep Track Capital, LP (1.15Mn), GEODE CAPITAL MANAGEMENT, LLC (1.01Mn), NOMURA ASSET MANAGEMENT INTERNATIONAL INC. (989.45K), State Street Corp (958.15K), RTW INVESTMENTS, LP (888.0K).

388 Institutional Holders

36,885,745 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
VANGUARD GROUP INC	31 Dec, 2025	4,164,818	-15,828	-0.38%	$760,662,360.00
BlackRock, Inc.	31 Dec, 2025	3,913,543	122,614	3.23%	$714,769,493.00
Invesco Ltd.	31 Dec, 2025	1,273,494	282,937	28.56%	$232,590,944.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	1,221,656	-112,904	-8.46%	$223,123,252.00
FMR LLC	31 Dec, 2025	1,181,622	253,739	27.35%	$215,811,444.00
Deep Track Capital, LP	31 Dec, 2025	1,150,000	250,000	27.78%	$210,036,000.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,010,249	12,549	1.26%	$184,544,219.00
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	31 Dec, 2025	989,447	989,447	0.00%	$180,713,000.00
State Street Corp	31 Dec, 2025	958,150	15,190	1.61%	$174,996,516.00
RTW INVESTMENTS, LP	31 Dec, 2025	888,001	-230,882	-20.64%	$162,184,503.00
ALETHEA CAPITAL MANAGEMENT, LLC	31 Dec, 2025	668,710	-2,173	-0.32%	$122,133,194.00
Bank Of America Corp /De/	31 Dec, 2025	618,033	-104,489	-14.46%	$112,877,457.00
Goldman Sachs Group Inc	31 Dec, 2025	601,812	377,673	168.50%	$109,914,944.00
EVENTIDE ASSET MANAGEMENT, LLC	31 Dec, 2025	571,226	-175,172	-23.47%	$104,195,166.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	549,113	252,826	85.33%	$100,289,998.00
NORGES BANK	31 Dec, 2025	495,456	495,456	0.00%	$90,490,084.00
Morgan Stanley	31 Dec, 2025	491,201	81,621	19.93%	$89,713,138.00
Assenagon Asset Management S.A.	31 Dec, 2025	467,982	173,211	58.76%	$85,472,232.00
Pictet Asset Management Holding SA	31 Dec, 2025	436,063	73,925	20.41%	$79,642,546.00
Rockefeller Capital Management L.P.	31 Dec, 2025	425,594	419,857	7,318.41%	$2,722,432.00

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