Axsome Therapeutics, Inc. (AXSM) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

49,149,251Shares Outstanding

371,444Shares held by institutions

$68,085,685Value of institutional holdings

71.85%Institutional ownership %

7.64%Shares Changed QoQ

373No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Axsome Therapeutics, Inc. (NASDAQ:AXSM) is held by 373 institutional firms.

The collective stake of institutional investors in Axsome Therapeutics moved to 71.9% in December 2025, a shift down from the 76.4% reported for September 2025.
In percentage terms, this reflects as a holdings change of 7.64% quarter on quarter, and an increase of 29.51% year over year.
During the quarter, 210 institutions bought more Axsome Therapeutics shares, 117 sold shares, and 46 of the 373 total investors held their position steady.
Collectively, institutional investors increased their stake in Axsome Therapeutics to 35.31Mn shares as of December 2025, a change that is up by 2.51Mn shares quarter on quarter and down 3.04Mn shares year over year.
With 4.16Mn shares, VANGUARD GROUP INC commands the largest institutional position in Axsome Therapeutics as of December 31, 2025, equating to 8.47% of the company.
Among the most significant buyers of Axsome Therapeutics during December 2025 were NOMURA ASSET MANAGEMENT INTERNATIONAL INC. (989.45K), NORGES BANK (495.46K), Rockefeller Capital Management L.P. (412.40K), BANK OF AMERICA CORP /DE/ (256.77K), FMR LLC (253.74K).
Leading sellers of Axsome Therapeutics stock in December 2025 included BVF INC/IL (441.00K), Sofinnova Investments, Inc. (381.23K), PFM Health Sciences, LP (278.77K), ORBIMED ADVISORS LLC (278.68K), T. Rowe Price Investment Management, Inc. (260.37K).
The top 10 institutional holders of Axsome Therapeutics for the quarter ending December 2025 included VANGUARD GROUP INC (4.16Mn), BlackRock, Inc. (3.91Mn), WELLINGTON MANAGEMENT GROUP LLP (1.22Mn), FMR LLC (1.18Mn), Deep Track Capital, LP (1.15Mn), GEODE CAPITAL MANAGEMENT, LLC (1.01Mn), NOMURA ASSET MANAGEMENT INTERNATIONAL INC. (989.45K), STATE STREET CORP (958.15K), RTW INVESTMENTS, LP (888.00K), ALETHEA CAPITAL MANAGEMENT, LLC (668.71K).

373 Institutional Holders

371,444 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
VANGUARD GROUP INC	31 Dec, 2025	4,164,818	-15,828	-0.38%	$760,662,360.00
BlackRock, Inc.	31 Dec, 2025	3,913,543	122,614	3.23%	$714,769,493.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	1,221,656	-112,904	-8.46%	$223,123,252.00
FMR LLC	31 Dec, 2025	1,181,622	253,739	27.35%	$215,811,444.00
Deep Track Capital, LP	31 Dec, 2025	1,150,000	250,000	27.78%	$210,036,000.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,010,249	12,549	1.26%	$184,544,219.00
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	31 Dec, 2025	989,447	989,447	0.00%	$180,713,000.00
STATE STREET CORP	31 Dec, 2025	958,150	15,190	1.61%	$174,996,516.00
RTW INVESTMENTS, LP	31 Dec, 2025	888,001	-230,882	-20.64%	$162,184,503.00
ALETHEA CAPITAL MANAGEMENT, LLC	31 Dec, 2025	668,710	-2,173	-0.32%	$122,133,194.00
BANK OF AMERICA CORP /DE/	31 Dec, 2025	618,033	256,772	71.08%	$112,877,457.00
EVENTIDE ASSET MANAGEMENT, LLC	31 Dec, 2025	571,226	-175,172	-23.47%	$104,195,166.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	549,113	252,826	85.33%	$100,289,998.00
NORGES BANK	31 Dec, 2025	495,456	495,456	0.00%	$90,490,084.00
MORGAN STANLEY	31 Dec, 2025	491,201	81,621	19.93%	$89,713,138.00
Assenagon Asset Management S.A.	31 Dec, 2025	467,982	173,211	58.76%	$85,472,232.00
Pictet Asset Management Holding SA	31 Dec, 2025	436,063	73,925	20.41%	$79,642,546.00
Rockefeller Capital Management L.P.	31 Dec, 2025	418,141	412,404	7,188.50%	$1,361,216.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	402,700	20,653	5.41%	$73,549,128.00
NORTHERN TRUST CORP	31 Dec, 2025	390,431	-19,104	-4.66%	$71,308,317.00

1 - 20 of 373

Research Tools