Axsome Therapeutics, Inc. (AXSM) Institutional Ownership

Ownership Summary

Axsome Therapeutics, Inc. (NASDAQ:AXSM) is held by 388 institutional investors per 13F filings through December 2025.

• Their combined ownership stood at 73.1% of outstanding shares in December 2025, down from 75.8% in September 2025.
• Their total shares held in AXSM increased 6.06% quarter over quarter, and separately, investors owning Axsome Therapeutics increased 34.72% from a year ago.
• Activity in AXSM broke down as 218 buyers, 121 sellers, and 49 unchanged among 388 total holders.
• In total, institutional investors held 36.56Mn shares in Axsome Therapeutics as of December 2025, up by 2.09Mn shares quarter on quarter, and down 2.17Mn shares year over year.
• As of December 31, 2025, BlackRock, Inc. held the largest stake in Axsome Therapeutics with 3.91Mn shares, accounting for 7.82% of total shares outstanding.
• The most significant purchases of AXSM for the quarter ending December 2025 came from VANGUARD PORTFOLIO MANAGEMENT LLC (2.06Mn), VANGUARD CAPITAL MANAGEMENT LLC (1.94Mn), PRICE T ROWE ASSOCIATES INC /MD/ (1.32Mn), FIRST TRUST ADVISORS LP (534.07K), Point72 Asset Management, L.P. (406.75K).
• The largest sellers of Axsome Therapeutics for the quarter ending December 2025 were Rockefeller Capital Management L.P. (421.87K), Goldman Sachs Group Inc (180.36K), MARSHALL WACE, LLP (179.33K), NOMURA ASSET MANAGEMENT INTERNATIONAL INC. (176.64K), Tri Locum Partners LP (139.51K).
• Per Business Quant, the top 10 investors in AXSM for the quarter ending December 2025 include BlackRock, Inc. (3.91Mn), VANGUARD PORTFOLIO MANAGEMENT LLC (2.06Mn), VANGUARD CAPITAL MANAGEMENT LLC (1.94Mn), FMR LLC (1.57Mn), PRICE T ROWE ASSOCIATES INC /MD/ (1.32Mn), Invesco Ltd. (1.3Mn), GEODE CAPITAL MANAGEMENT, LLC (1.16Mn), WELLINGTON MANAGEMENT GROUP LLP (1.15Mn), Deep Track Capital, LP (1.1Mn), State Street Corp (986.81K).