Growth Metrics

Axsome Therapeutics (AXSM) Gross Profit (2022 - 2026)

Axsome Therapeutics recorded quarterly Gross Profit of $176.5 million in Q1 2026, down 3.92% quarter-over-quarter from $183.7 million in Q4 2025, and up 58.03% year-over-year from $111.7 million in Q1 2025.

Axsome Therapeutics' Gross Profit history runs 5 years deep, the most recent figure standing at $176.5 million for Q1 2026.

  • In Q1 2026, Gross Profit rose 58.03% year-over-year to $176.5 million; the TTM figure through Mar 2026 stood at $655.8 million (up 136.68% YoY), while the FY2025 annual figure was $591.0 million, up 67.72% from the prior year.
  • Gross Profit came in at $176.5 million for Q1 2026 at Axsome Therapeutics, down from $183.7 million in the prior quarter.
  • In the past five years, Gross Profit ranged from a high of $183.7 million in Q4 2025 to a low of -$10.0 million in Q4 2024.
  • A 5-year average of $80.7 million and a median of $73.9 million in 2024 frame the typical range for Gross Profit.
  • Across the five-year window, Gross Profit plunged 115.61% in 2024 and soared 1934.13% in 2025, its largest moves.
  • Axsome Therapeutics' Gross Profit stood at $22.1 million in 2022, then soared by 190.54% to $64.2 million in 2023, then slumped by 115.61% to -$10.0 million in 2024, then jumped by 1934.13% to $183.7 million in 2025, then slipped by 3.92% to $176.5 million in 2026.
  • According to Business Quant data, Gross Profit over the past three periods registered $176.5 million, $183.7 million, and $159.1 million for Q1 2026, Q4 2025, and Q3 2025 respectively.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn -
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn -
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn
7 Evaxion A 62.56 Bn 62.54 Bn -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn
10 Axsome Therapeutics 11.82 Bn 11.51 Bn 176.48 Mn

Historic Data

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DateValue
Mar 31, 2026 176.48 Mn
Mar 31, 2026 176.48 Mn
Dec 31, 2025 183.67 Mn
Dec 31, 2025 183.67 Mn
Sep 30, 2025 159.08 Mn
Sep 30, 2025 159.08 Mn
Jun 30, 2025 136.59 Mn
Jun 30, 2025 136.59 Mn
Mar 31, 2025 111.67 Mn
Mar 31, 2025 111.67 Mn
Dec 31, 2024 -10.01 Mn
Dec 31, 2024 -10.01 Mn
Sep 30, 2024 96.33 Mn
Sep 30, 2024 96.33 Mn
Jun 30, 2024 79.11 Mn
Jun 30, 2024 79.11 Mn
Mar 31, 2024 68.70 Mn
Mar 31, 2024 68.70 Mn
Dec 31, 2023 64.15 Mn
Dec 31, 2023 64.15 Mn
Sep 30, 2023 51.26 Mn
Sep 30, 2023 51.26 Mn
Jun 30, 2023 42.10 Mn
Jun 30, 2023 42.10 Mn
Mar 31, 2023 87.02 Mn
Mar 31, 2023 87.02 Mn
Dec 31, 2022 22.08 Mn
Dec 31, 2022 22.08 Mn
Sep 30, 2022 14.92 Mn
Sep 30, 2022 14.92 Mn
Jun 30, 2022 7.84 Mn
Jun 30, 2022 7.84 Mn