Axsome Therapeutics (AXSM) Operating Income (2015 - 2026)
Axsome Therapeutics' (AXSM) quarterly Operating Income came in at -$63.4 million in Q1 2026, down 11.19% year-on-year from -$71.3 million in Q1 2025, and down 162.53% quarter-over-quarter from $101.3 million in Q4 2025.
Axsome Therapeutics (AXSM) Operating Income (2015 - 2026) Analysis & Trends
Axsome Therapeutics has disclosed Operating Income across 12 years of filings, most recently posting -$63.4 million for Q1 2026.
- Operating Income for Q1 2026 came in at -$63.4 million, down 11.19% year-over-year; the trailing twelve-month figure through Mar 2026 was -$44.9 million (up 83.4% YoY), and the FY2025 annual result was -$38.5 million, up 86.29% from the prior year.
- Operating Income came in at -$63.4 million for Q1 2026 at Axsome Therapeutics, down from $101.3 million in the prior quarter.
- In the past five years, Operating Income ranged from a high of $101.3 million in Q4 2025 to a low of -$98.3 million in Q4 2023.
- The 5-year median for Operating Income is -$59.9 million (2022), against an average of -$46.7 million.
- Across the five-year window, Operating Income tumbled 955.46% in 2024 and soared 239.53% in 2025, its largest moves.
- Axsome Therapeutics' Operating Income stood at -$59.9 million in 2022, then plunged by 64.01% to -$98.3 million in 2023, then advanced by 26.11% to -$72.6 million in 2024, then jumped by 239.53% to $101.3 million in 2025, then plunged by 162.53% to -$63.4 million in 2026.
- The last three Operating Income figures came in at -$63.4 million (Q1 2026), $101.3 million (Q4 2025), and -$46.1 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Op. Inc (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | -32.68 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -2.97 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -19.70 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -3.82 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -15.76 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.14 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -65.83 Mn |
| 10 | Axsome Therapeutics | 12.84 Bn | 12.54 Bn | 176.48 Mn | -63.36 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -63.36 Mn |
| Dec 31, 2025 | 101.33 Mn |
| Sep 30, 2025 | -46.11 Mn |
| Jun 30, 2025 | -36.71 Mn |
| Mar 31, 2025 | -56.98 Mn |
| Dec 31, 2024 | -72.62 Mn |
| Sep 30, 2024 | -62.62 Mn |
| Jun 30, 2024 | -78.05 Mn |
| Mar 31, 2024 | -67.28 Mn |
| Dec 31, 2023 | -98.27 Mn |
| Sep 30, 2023 | -62.12 Mn |
| Jun 30, 2023 | -65.06 Mn |
| Mar 31, 2023 | -6.37 Mn |
| Dec 31, 2022 | -59.92 Mn |
| Sep 30, 2022 | -42.41 Mn |
| Jun 30, 2022 | -39.18 Mn |
| Mar 31, 2022 | -38.29 Mn |
| Dec 31, 2021 | -32.61 Mn |
| Sep 30, 2021 | -33.41 Mn |
| Jun 30, 2021 | -30.85 Mn |