Axsome Therapeutics (AXSM) Operating Expenses (2015 - 2026)

Axsome Therapeutics' (AXSM) quarterly Operating Expenses came in at $254.6 million in Q1 2026, up 42.65% year-on-year from $178.4 million in Q1 2025, and up 14.17% quarter-over-quarter from $223.0 million in Q4 2025.

Axsome Therapeutics (AXSM) Operating Expenses (2015 - 2026) Analysis & Trends

Axsome Therapeutics has disclosed Operating Expenses across 12 years of filings, most recently posting $254.6 million for Q1 2026.

  • Operating Expenses for Q1 2026 came in at $254.6 million, up 42.65% year-over-year; the trailing twelve-month figure through Mar 2026 was $881.4 million (up 25.48% YoY), and the FY2025 annual result was $805.3 million, up 20.86% from the prior year.
  • Operating Expenses came in at $254.6 million for Q1 2026 at Axsome Therapeutics, up from $223.0 million in the prior quarter.
  • In the past five years, Operating Expenses ranged from a high of $254.6 million in Q1 2026 to a low of $38.3 million in Q1 2022.
  • The 5-year median for Operating Expenses is $165.2 million (2024), against an average of $144.6 million.
  • Across the five-year window, Operating Expenses surged 163.65% in 2023 and gained 12.71% in 2024, its largest moves.
  • Axsome Therapeutics' Operating Expenses stood at $84.3 million in 2022, then jumped by 101.45% to $169.8 million in 2023, then grew by 12.71% to $191.4 million in 2024, then rose by 16.5% to $223.0 million in 2025, then climbed by 14.17% to $254.6 million in 2026.
  • The last three Operating Expenses figures came in at $254.6 million (Q1 2026), $223.0 million (Q4 2025), and $217.1 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 4.33 Mn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - 32.68 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -138.30 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 15.76 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - 574,669.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.85 Bn
9 Abivax 91.96 Bn 91.96 Bn - -67.40 Mn
10 Axsome Therapeutics 12.84 Bn 12.54 Bn 176.48 Mn 254.56 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 254.56 Mn
Dec 31, 2025 222.96 Mn
Sep 30, 2025 217.10 Mn
Jun 30, 2025 186.76 Mn
Mar 31, 2025 178.45 Mn
Dec 31, 2024 191.38 Mn
Sep 30, 2024 167.39 Mn
Jun 30, 2024 165.21 Mn
Mar 31, 2024 142.27 Mn
Dec 31, 2023 169.80 Mn
Sep 30, 2023 119.91 Mn
Jun 30, 2023 111.76 Mn
Mar 31, 2023 100.95 Mn
Dec 31, 2022 84.29 Mn
Sep 30, 2022 59.26 Mn
Jun 30, 2022 48.00 Mn
Mar 31, 2022 38.29 Mn
Dec 31, 2021 32.61 Mn
Sep 30, 2021 33.41 Mn
Jun 30, 2021 30.85 Mn