Lyell Immunopharma (LYEL) Operating Margin (2020 - 2026)
Lyell Immunopharma (LYEL) recorded Operating Margin of -1183425.00% in Q2 2026, down 594175.00 percentage points from -589250.00% a year earlier but up 1029625.00 percentage points from the prior quarter.
Lyell Immunopharma (LYEL) Operating Margin (2020 - 2026) Analysis & Trends
On a TTM basis, Lyell Immunopharma's Operating Margin came in at -949981.48% as of Jun 30, 2026, down 356383.15 percentage points year-over-year; for FY2025, it was -748344.44%, down 160221.49 percentage points from FY2024.
- Annual Operating Margin has declined for three straight years, with a five-year change of -745611.89 percentage points (FY2020 to FY2025).
- Across earlier years, Operating Margin came in at -588122.95% in FY2024 (-398116.80 pp), -190006.15% in FY2023 (-189785.26 pp), -220.89% in FY2022 (+1795.78 pp) and -2016.68% in FY2021 (+715.88 pp).
- Quarterly Operating Margin has ranged from -2214566.67% in Q3 2022 to -30.55% in Q4 2022 over the past five years.
- On a year-over-year basis, Operating Margin has declined for five consecutive quarters, with an average year-over-year change of -353681.16 percentage points over the last eight quarters.
- Peak year-over-year performance for Operating Margin in the last five years was a gain of 1978410.67 percentage points in Q3 2023, against a drop of 2212782.24 percentage points in Q3 2022 at the low end.
- Per Business Quant, the preceding three quarters came in at -2213050.00% (Q1 2026), -2127400.00% (Q4 2025) and -248353.33% (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Lyell Immunopharma | 227.89 Mn | 227.89 Mn | - | -1,183,425.00% |
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -1,183,425.00% |
| Mar 31, 2026 | -2,213,050.00% |
| Dec 31, 2025 | -2,127,400.00% |
| Sep 30, 2025 | -248,353.33% |
| Jun 30, 2025 | -589,250.00% |
| Mar 31, 2025 | -819,528.57% |
| Dec 31, 2024 | -1,828,609.09% |
| Sep 30, 2024 | -148,544.12% |
| Jun 30, 2024 | -396,369.23% |
| Mar 31, 2024 | -1,852,500.00% |
| Dec 31, 2023 | -457,753.85% |
| Sep 30, 2023 | -236,156.00% |
| Jun 30, 2023 | -244,092.59% |
| Mar 31, 2023 | -96,240.00% |
| Dec 31, 2022 | -30.55% |
| Sep 30, 2022 | -2,214,566.67% |
| Jun 30, 2022 | -104.25% |
| Mar 31, 2022 | -12,400.72% |
| Dec 31, 2021 | -1,684.55% |
| Sep 30, 2021 | -1,784.43% |
Lyell Immunopharma Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=LYEL&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "LYEL", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=LYEL&period=max&api_key=YOUR_API_KEY");
const data = await res.json();