Lyell Immunopharma (LYEL) Operating Expenses (2020 - 2026)
Lyell Immunopharma (LYEL) reported Operating Expenses of $44.3 million for Q1 2026, down 22.85% on a YoY basis from $57.4 million in Q1 2025, and down 65.32% sequentially from $127.6 million in Q4 2025.
Lyell Immunopharma (LYEL) Operating Expenses (2020 - 2026) Analysis & Trends
Lyell Immunopharma (LYEL) has 7 years of Operating Expenses data on file, last reported at $44.3 million in Q1 2026.
- For the quarter ending Q1 2026, Operating Expenses fell 22.85% year-over-year to $44.3 million; the trailing twelve-month figure through Mar 2026 stood at $256.3 million (down 28.92% YoY), and the FY2025 full-year result was $269.4 million, down 24.91% from the prior year.
- Operating Expenses slipped to $44.3 million in Q1 2026, from $127.6 million in the prior quarter.
- In the past five years, Operating Expenses ranged from a high of $201.2 million in Q4 2024 to a low of $37.3 million in Q3 2025.
- A 5-year average of $70.1 million and a median of $59.5 million in 2023 frame the typical range for Operating Expenses.
- Across the five-year window, Operating Expenses jumped 237.96% in 2024 and sank 36.54% in 2025, its largest moves.
- Tracing LYEL's Operating Expenses over 5 years: stood at $63.2 million in 2022, then declined by 5.78% to $59.5 million in 2023, then jumped by 237.96% to $201.2 million in 2024, then slumped by 36.54% to $127.6 million in 2025, then sank by 65.32% to $44.3 million in 2026.
- Business Quant data shows LYEL's Operating Expenses at $44.3 million in Q1 2026, $127.6 million in Q4 2025, and $37.3 million in Q3 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | -28.01 Mn |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | 15.76 Mn |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 1.10 Bn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 1.85 Bn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 2.96 Bn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | 32.68 Mn |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | -919.00 Mn |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | 445.22 Mn |
| 10 | Lyell Immunopharma | 276.08 Mn | 276.08 Mn | - | 44.26 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 44.26 Mn |
| Dec 31, 2025 | 127.65 Mn |
| Sep 30, 2025 | 37.27 Mn |
| Jun 30, 2025 | 47.15 Mn |
| Mar 31, 2025 | 57.37 Mn |
| Dec 31, 2024 | 201.16 Mn |
| Sep 30, 2024 | 50.54 Mn |
| Jun 30, 2024 | 51.54 Mn |
| Mar 31, 2024 | 55.58 Mn |
| Dec 31, 2023 | 59.52 Mn |
| Sep 30, 2023 | 59.06 Mn |
| Jun 30, 2023 | 65.93 Mn |
| Mar 31, 2023 | 62.62 Mn |
| Dec 31, 2022 | 63.17 Mn |
| Sep 30, 2022 | 66.44 Mn |
| Jun 30, 2022 | 73.00 Mn |
| Mar 31, 2022 | 69.13 Mn |
| Dec 31, 2021 | 50.36 Mn |
| Sep 30, 2021 | 51.92 Mn |
| Jun 30, 2021 | 65.34 Mn |