Lyell Immunopharma (LYEL) Operating Expenses (2020 - 2026)

Lyell Immunopharma (LYEL) reported Operating Expenses of $44.3 million for Q1 2026, down 22.85% on a YoY basis from $57.4 million in Q1 2025, and down 65.32% sequentially from $127.6 million in Q4 2025.

Lyell Immunopharma (LYEL) Operating Expenses (2020 - 2026) Analysis & Trends

Lyell Immunopharma (LYEL) has 7 years of Operating Expenses data on file, last reported at $44.3 million in Q1 2026.

  • For the quarter ending Q1 2026, Operating Expenses fell 22.85% year-over-year to $44.3 million; the trailing twelve-month figure through Mar 2026 stood at $256.3 million (down 28.92% YoY), and the FY2025 full-year result was $269.4 million, down 24.91% from the prior year.
  • Operating Expenses slipped to $44.3 million in Q1 2026, from $127.6 million in the prior quarter.
  • In the past five years, Operating Expenses ranged from a high of $201.2 million in Q4 2024 to a low of $37.3 million in Q3 2025.
  • A 5-year average of $70.1 million and a median of $59.5 million in 2023 frame the typical range for Operating Expenses.
  • Across the five-year window, Operating Expenses jumped 237.96% in 2024 and sank 36.54% in 2025, its largest moves.
  • Tracing LYEL's Operating Expenses over 5 years: stood at $63.2 million in 2022, then declined by 5.78% to $59.5 million in 2023, then jumped by 237.96% to $201.2 million in 2024, then slumped by 36.54% to $127.6 million in 2025, then sank by 65.32% to $44.3 million in 2026.
  • Business Quant data shows LYEL's Operating Expenses at $44.3 million in Q1 2026, $127.6 million in Q4 2025, and $37.3 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -28.01 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - 15.76 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 1.10 Bn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.85 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 2.96 Bn
7 Belite Bio 61.40 Bn 61.40 Bn - 32.68 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn -919.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - 445.22 Mn
10 Lyell Immunopharma 276.08 Mn 276.08 Mn - 44.26 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 44.26 Mn
Dec 31, 2025 127.65 Mn
Sep 30, 2025 37.27 Mn
Jun 30, 2025 47.15 Mn
Mar 31, 2025 57.37 Mn
Dec 31, 2024 201.16 Mn
Sep 30, 2024 50.54 Mn
Jun 30, 2024 51.54 Mn
Mar 31, 2024 55.58 Mn
Dec 31, 2023 59.52 Mn
Sep 30, 2023 59.06 Mn
Jun 30, 2023 65.93 Mn
Mar 31, 2023 62.62 Mn
Dec 31, 2022 63.17 Mn
Sep 30, 2022 66.44 Mn
Jun 30, 2022 73.00 Mn
Mar 31, 2022 69.13 Mn
Dec 31, 2021 50.36 Mn
Sep 30, 2021 51.92 Mn
Jun 30, 2021 65.34 Mn