Lyell Immunopharma (LYEL) Operating Expenses (2020 - 2026)

Lyell Immunopharma recorded quarterly Operating Expenses of $44.3 million in Q1 2026, down 65.32% quarter-over-quarter from $127.6 million in Q4 2025, and down 22.85% year-over-year from $57.4 million in Q1 2025.

Lyell Immunopharma's Operating Expenses history runs 7 years deep, the most recent figure standing at $44.3 million for Q1 2026.

  • In Q1 2026, Operating Expenses fell 22.85% year-over-year to $44.3 million; the TTM figure through Mar 2026 stood at $256.3 million (down 28.92% YoY), while the FY2025 annual figure was $269.4 million, down 24.91% from the prior year.
  • Operating Expenses came in at $44.3 million for Q1 2026 at Lyell Immunopharma, down from $127.6 million in the prior quarter.
  • In the past five years, Operating Expenses ranged from a high of $201.2 million in Q4 2024 to a low of $37.3 million in Q3 2025.
  • A 5-year average of $70.1 million and a median of $59.5 million in 2023 frame the typical range for Operating Expenses.
  • Across the five-year window, Operating Expenses surged 237.96% in 2024 and slumped 36.54% in 2025, its largest moves.
  • Lyell Immunopharma's Operating Expenses stood at $63.2 million in 2022, then retreated by 5.78% to $59.5 million in 2023, then soared by 237.96% to $201.2 million in 2024, then plunged by 36.54% to $127.6 million in 2025, then tumbled by 65.32% to $44.3 million in 2026.
  • According to Business Quant data, Operating Expenses over the past three periods registered $44.3 million, $127.6 million, and $37.3 million for Q1 2026, Q4 2025, and Q3 2025 respectively.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Quantum Biopharma 1,216,509.61 Bn 1,216,509.61 Bn - 2.97 Mn
2 Alterity Therapeutics 764,224.41 Bn 764,224.38 Bn - 4.33 Mn
3 Legend Biotech 2,716.00 Bn 2,715.71 Bn 242.10 Mn -138.30 Mn
4 Nanobiotix 2,248.83 Bn 2,248.77 Bn - -
5 Akari Therapeutics 1,951.18 Bn 1,951.17 Bn - 15.76 Mn
6 Vertex Pharmaceuticals 113.69 Bn 106.44 Bn 2.59 Bn 1.85 Bn
7 Evaxion A 64.16 Bn 64.14 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 63.94 Bn 55.18 Bn 3.31 Bn 2.96 Bn
9 Alnylam Pharmaceuticals 40.13 Bn 37.12 Bn 959.66 Mn 898.54 Mn
10 Lyell Immunopharma 379.11 Mn 379.11 Mn - 44.26 Mn

Historic Data

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DateValue
Mar 31, 2026 44.26 Mn
Dec 31, 2025 127.65 Mn
Sep 30, 2025 37.27 Mn
Jun 30, 2025 47.15 Mn
Mar 31, 2025 57.37 Mn
Dec 31, 2024 201.16 Mn
Sep 30, 2024 50.54 Mn
Jun 30, 2024 51.54 Mn
Mar 31, 2024 55.58 Mn
Dec 31, 2023 59.52 Mn
Sep 30, 2023 59.06 Mn
Jun 30, 2023 65.93 Mn
Mar 31, 2023 62.62 Mn
Dec 31, 2022 63.17 Mn
Sep 30, 2022 66.44 Mn
Jun 30, 2022 73.00 Mn
Mar 31, 2022 69.13 Mn
Dec 31, 2021 50.36 Mn
Sep 30, 2021 51.92 Mn
Jun 30, 2021 65.34 Mn
Mar 31, 2021 57.82 Mn
Dec 31, 2020 41.84 Mn
Sep 30, 2020 37.91 Mn
Jun 30, 2020 105.68 Mn