Lyell Immunopharma LYEL
NASDAQ LYEL
$14.37 +0.05 (+0.35%)
As of: Sep 4, 2026 · 3:59 PM EDT

Lyell Immunopharma (LYEL) Operating Income (2020 - 2026)

Lyell Immunopharma (LYEL) posted Operating Income of -$44.3 million for Q1 2026, up 65.32% sequentially from -$127.6 million in Q4 2025, and up 22.85% YoY from -$36.0 million in Q1 2025.

Analysis

Lyell Immunopharma (LYEL) Operating Income (2020 - 2026) Analysis & Trends

Lyell Immunopharma has reported Operating Income for 7 years, with the latest figure at -$44.3 million in Q1 2026.

  • Quarterly Operating Income rose 22.85% year-over-year to -$44.3 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$256.3 million (up 28.91% YoY) and the FY2025 annual result came in at -$269.4 million, up 24.91% from the prior year.
  • Operating Income advanced to -$44.3 million in Q1 2026 per LYEL's latest filing, from -$127.6 million in the prior quarter.
  • Over five years, Operating Income peaked at -$14.8 million in Q4 2022 and troughed at -$201.1 million in Q4 2024.
  • A 5-year average of -$65.1 million and a median of -$57.4 million in 2025 frame the typical range for Operating Income.
  • The sharpest annual moves came in 2022 and 2023: Operating Income soared 68.9% in 2022, then plunged 302.52% in 2023.
  • Over 5 years, Operating Income stood at -$14.8 million in 2022, then slumped by 302.52% to -$59.5 million in 2023, then plunged by 238.02% to -$201.1 million in 2024, then soared by 36.54% to -$127.6 million in 2025, then surged by 65.32% to -$44.3 million in 2026.
  • According to Business Quant data, Operating Income over the past three periods registered -$44.3 million, -$127.6 million, and -$37.3 million for Q1 2026, Q4 2025, and Q3 2025 respectively.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 1.25 Bn
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn 1.29 Bn
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn 493.00 Mn
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn -815.00 Mn
5 Revolution Medicines 44.33 Bn 44.33 Bn - -505.13 Mn
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 325.05 Mn
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn 231.44 Mn
8 Royalty Pharma 28.45 Bn 27.61 Bn - 133.12 Mn
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn -1.55 Mn
10 Lyell Immunopharma 335.97 Mn 335.97 Mn - -47.34 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -47.34 Mn
Mar 31, 2026 -44.26 Mn
Dec 31, 2025 -127.64 Mn
Sep 30, 2025 -37.25 Mn
Jun 30, 2025 -47.14 Mn
Mar 31, 2025 -57.37 Mn
Dec 31, 2024 -201.15 Mn
Sep 30, 2024 -50.51 Mn
Jun 30, 2024 -51.53 Mn
Mar 31, 2024 -55.58 Mn
Dec 31, 2023 -59.51 Mn
Sep 30, 2023 -59.04 Mn
Jun 30, 2023 -65.91 Mn
Mar 31, 2023 -62.56 Mn
Dec 31, 2022 -14.78 Mn
Sep 30, 2022 -66.44 Mn
Jun 30, 2022 -37.26 Mn
Mar 31, 2022 -68.58 Mn
Dec 31, 2021 -47.54 Mn
Sep 30, 2021 -49.16 Mn