Lyell Immunopharma (LYEL) Operating Income (2020 - 2026)

Lyell Immunopharma recorded quarterly Operating Income of -$44.3 million in Q1 2026, up 65.32% quarter-over-quarter from -$127.6 million in Q4 2025, and up 22.85% year-over-year from -$36.0 million in Q1 2025.

Lyell Immunopharma's Operating Income history runs 7 years deep, the most recent figure standing at -$44.3 million for Q1 2026.

  • In Q1 2026, Operating Income rose 22.85% year-over-year to -$44.3 million; the TTM figure through Mar 2026 stood at -$256.3 million (up 28.91% YoY), while the FY2025 annual figure was -$269.4 million, up 24.91% from the prior year.
  • Operating Income came in at -$44.3 million for Q1 2026 at Lyell Immunopharma, up from -$127.6 million in the prior quarter.
  • In the past five years, Operating Income ranged from a high of -$14.8 million in Q4 2022 to a low of -$201.1 million in Q4 2024.
  • A 5-year average of -$65.1 million and a median of -$57.4 million in 2025 frame the typical range for Operating Income.
  • Across the five-year window, Operating Income surged 68.9% in 2022 and tumbled 302.52% in 2023, its largest moves.
  • Lyell Immunopharma's Operating Income stood at -$14.8 million in 2022, then sank by 302.52% to -$59.5 million in 2023, then tumbled by 238.02% to -$201.1 million in 2024, then surged by 36.54% to -$127.6 million in 2025, then jumped by 65.32% to -$44.3 million in 2026.
  • According to Business Quant data, Operating Income over the past three periods registered -$44.3 million, -$127.6 million, and -$37.3 million for Q1 2026, Q4 2025, and Q3 2025 respectively.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Quantum Biopharma 1,216,509.61 Bn 1,216,509.61 Bn - -2.97 Mn
2 Alterity Therapeutics 764,224.41 Bn 764,224.38 Bn - -
3 Legend Biotech 2,716.00 Bn 2,715.71 Bn 242.10 Mn -19.70 Mn
4 Nanobiotix 2,248.83 Bn 2,248.77 Bn - -
5 Akari Therapeutics 1,951.18 Bn 1,951.17 Bn - -15.76 Mn
6 Vertex Pharmaceuticals 113.69 Bn 106.44 Bn 2.59 Bn 1.14 Bn
7 Evaxion A 64.16 Bn 64.14 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 63.94 Bn 55.18 Bn 3.31 Bn 642.90 Mn
9 Alnylam Pharmaceuticals 40.13 Bn 37.12 Bn 959.66 Mn 268.64 Mn
10 Lyell Immunopharma 379.11 Mn 379.11 Mn - -44.26 Mn

Historic Data

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DateValue
Mar 31, 2026 -44.26 Mn
Dec 31, 2025 -127.64 Mn
Sep 30, 2025 -37.25 Mn
Jun 30, 2025 -47.14 Mn
Mar 31, 2025 -57.37 Mn
Dec 31, 2024 -201.15 Mn
Sep 30, 2024 -50.51 Mn
Jun 30, 2024 -51.53 Mn
Mar 31, 2024 -55.58 Mn
Dec 31, 2023 -59.51 Mn
Sep 30, 2023 -59.04 Mn
Jun 30, 2023 -65.91 Mn
Mar 31, 2023 -62.56 Mn
Dec 31, 2022 -14.78 Mn
Sep 30, 2022 -66.44 Mn
Jun 30, 2022 -37.26 Mn
Mar 31, 2022 -68.58 Mn
Dec 31, 2021 -47.54 Mn
Sep 30, 2021 -49.16 Mn
Jun 30, 2021 -62.71 Mn
Mar 31, 2021 -55.37 Mn
Dec 31, 2020 -39.52 Mn
Sep 30, 2020 -36.84 Mn
Jun 30, 2020 -102.57 Mn