Ionis Pharmaceuticals Ratios (2009-2025) | IONS

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Ratios	Jun2009	Sep2009	Dec2009	Mar2010	Jun2010	Sep2010	Dec2010	Mar2011	Jun2011	Sep2011	Dec2011	Mar2012	Jun2012	Sep2012	Dec2012	Mar2013	Jun2013	Sep2013	Dec2013	Mar2014	Jun2014	Sep2014	Dec2014	Mar2015	Jun2015	Sep2015	Dec2015	Mar2016	Jun2016	Sep2016	Dec2016	Mar2017	Jun2017	Sep2017	Dec2017	Mar2018	Jun2018	Sep2018	Dec2018	Mar2019	Jun2019	Sep2019	Dec2019	Mar2020	Jun2020	Sep2020	Dec2020	Mar2021	Jun2021	Sep2021	Dec2021	Mar2022	Jun2022	Sep2022	Dec2022	Mar2023	Jun2023	Sep2023	Dec2023	Mar2024	Jun2024	Sep2024	Dec2024	Mar2025	Jun2025	Sep2025
Profitability
Gross Margin																																							99.05%	99.31%	77.27%	96.13%	97.75%	98.09%	76.83%	98.07%	91.99%	97.69%	97.65%	97.69%	99.49%	97.06%	96.45%	99.05%	97.57%	98.97%	98.65%	98.48%	99.06%	98.20%	98.15%	99.20%	98.31%	98.89%	98.51%	98.51%
EBT Margin	-4.85%	-44.93%	-44.99%	-32.27%	-107.02%	-43.51%	-52.60%	-94.54%	-72.03%	-129.78%	-61.83%	-103.26%	-2.55%	-330.53%	-118.73%	-4.00%	-29.68%	-126.19%	-56.22%	-119.16%	-19.62%	-57.37%	18.43%	-27.97%	39.95%	-72.83%	-137.79%	-170.00%	-148.39%	6.63%	422.72%	7.74%	-2.55%	-5.52%	-36.29%	-35.99%	-47.74%	-165.94%	5.60%	81.29%	-282.32%	14.07%	511.68%	-39.71%	-272.89%	-19.71%	-41.85%	-80.41%	-64.05%	-62.94%	50.93%	-45.15%	-76.89%	-29.24%	-29.52%	-86.53%	-41.11%	-97.64%	-1.08%	-119.44%	-29.39%	-107.69%	-47.53%	-111.56%	44.44%	-81.93%
EBIT Margin	-2.04%	-38.83%	-36.18%	-16.31%	-79.45%	-31.26%	-60.02%	-76.17%	-56.64%	-107.74%	-57.45%	-79.43%	7.81%	-241.76%	-280.85%	3.75%	-20.81%	-108.14%	-47.00%	-105.35%	-11.65%	-48.78%	11.88%	-14.91%	48.95%	-98.00%	-122.05%	-148.21%	-127.18%	14.52%	316.58%	16.83%	5.74%	9.56%	-13.78%	-11.00%	-42.70%	-154.77%	5.61%	81.02%	-313.78%	10.09%	579.23%	-45.83%	-398.11%	-22.82%	-55.01%	-82.41%	-58.03%	-64.50%	50.14%	-40.52%	-63.92%	-37.03%	-136.95%	-87.45%	-47.87%	-99.35%	-1.89%	-125.12%	-29.34%	-111.09%	-48.91%	-111.59%	50.29%	-102.21%
EBITDA Margin	-2.04%	-38.83%	-36.18%	-16.31%	-79.45%	-31.26%	-60.02%	-76.17%	-56.64%	-137.28%	-57.45%	-79.43%	7.81%	-325.50%	-280.85%	3.75%	-20.81%	-108.14%	-47.00%	-105.35%	-11.65%	-48.78%	11.88%	-14.91%	48.95%	-98.00%	-122.05%	-148.21%	-127.18%	14.52%	316.58%	16.83%	5.74%	9.56%	-13.78%	-11.00%	-42.70%	-154.77%	5.61%	81.02%	-313.78%	10.09%	579.23%	-45.83%	-398.11%	-22.82%	-55.01%	-82.41%	-58.03%	-64.50%	50.14%	-40.52%	-63.92%	-37.03%	-136.95%	-87.45%	-47.87%	-99.35%	-1.89%	-125.12%	-29.34%	-111.09%	-48.91%	-111.59%	50.29%	-102.21%
Operating Margin	-2.04%	-38.83%	-36.18%	-16.31%	-79.45%	-31.26%	-60.02%	-76.17%	-56.64%	-107.74%	-57.45%	-79.43%	7.81%	-241.76%	-280.85%	3.75%	-20.81%	-108.14%	-47.00%	-105.35%	-11.65%	-48.78%	11.88%	-14.91%	48.95%	-98.00%	-122.05%	-148.21%	-127.18%	14.52%	316.58%	16.83%	5.74%	9.56%	-13.78%	-11.00%	-42.70%	-154.77%	5.61%	81.02%	-313.78%	10.09%	579.23%	-45.83%	-398.11%	-22.82%	-55.01%	-82.41%	-58.03%	-64.50%	50.14%	-40.52%	-63.92%	-37.03%	-136.95%	-87.45%	-47.87%	-99.35%	-1.89%	-125.12%	-29.34%	-111.09%	-48.91%	-111.59%	50.29%	-102.21%
Net Margin	592.30%	0.13%	-4.64%	-32.27%	-107.02%	-43.51%	-52.93%	-94.55%	-72.07%	-129.78%	-61.83%	-103.27%	-2.55%	-324.45%	-28.35%	-3.86%	-26.58%	-104.18%	-57.46%	-111.08%	-21.17%	-60.54%	36.59%	-26.71%	39.09%	-72.83%	-138.51%	-170.63%	-147.79%	6.63%	400.16%	7.74%	-2.75%	-6.33%	-20.37%	-36.04%	-0.51%	-38.48%	157.58%	58.36%	-15.55%	104.63%	417.68%	-29.77%	-197.30%	-15.35%	-869.80%	-80.52%	-64.31%	-61.96%	50.85%	-45.92%	-78.61%	-29.42%	-34.85%	-95.26%	-45.27%	-102.22%	-3.08%	-119.52%	-29.42%	-104.98%	-46.35%	-111.64%	44.44%	-82.06%
FCF Margin		-125.89%	-102.64%	-109.27%	17.64%	-77.82%	-98.41%	-200.59%	-119.18%	-126.11%	-74.10%	-29.37%	-7.03%	-215.84%	382.68%	-24.90%	58.73%	276.87%	-35.34%	-119.78%	-62.57%	2.44%	79.11%	-69.83%	68.14%	71.00%	-77.34%	-207.18%	-94.67%	20.95%	-227.95%	103.13%	-3.43%	9.86%	26.98%	36.07%	419.21%	-243.73%	59.40%	69.65%	-518.75%	-114.82%	600.17%	-12.50%	-410.12%	-13.79%	225.31%	-50.56%	-53.29%	-44.25%	45.72%	-24.21%	-16.02%	-18.76%	-134.53%	-110.68%	-58.05%	-77.09%	10.38%	-129.23%	-55.99%	-92.70%	-62.51%	-124.12%	50.01%	-87.23%
Efficiency
Inventory Average																																							0.01B	0.01B	0.01B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.02B	0.03B	0.02B	0.02B	0.03B	0.03B	0.02B	0.01B	0.01B	0.01B
Assets Average						0.59B	0.56B	0.53B	0.52B	0.52B	0.50B	0.48B	0.47B	0.48B	0.52B	0.55B	0.67B	0.84B	0.86B	0.84B	0.83B	0.81B	0.87B	0.96B	0.97B	0.98B	0.97B	0.91B	0.84B	0.83B	0.88B	1.00B	1.09B	1.17B	1.29B	1.31B	1.77B	2.25B	2.46B	2.75B	2.86B	2.89B	3.06B	3.16B	3.08B	3.09B	2.74B	2.32B	2.37B	2.46B	2.51B	2.57B	2.49B	2.44B	2.48B	2.71B	2.93B	2.95B	2.96B	2.88B	2.73B	2.89B	3.04B	2.91B	2.90B	3.01B
Equity Average						0.26B	0.25B	0.24B	0.22B	0.20B	0.18B	0.16B	0.15B	0.16B	0.09B	0.11B	0.30B	0.40B	0.39B	0.38B	0.20B	0.02B	0.14B	0.15B	0.03B	0.00B	0.09B	0.09B	-0.02B	-0.03B	0.01B	0.00B	-0.03B	-0.03B	0.17B	0.38B	0.60B	0.83B	1.01B	1.29B	1.42B	1.48B	1.59B	1.63B	1.58B	1.60B	1.17B	0.71B	0.63B	0.56B	0.65B	0.74B	0.67B	0.61B	0.58B	0.53B	0.46B	0.37B	0.35B	0.34B	0.28B	0.46B	0.63B	0.53B	0.55B	0.62B
Invested Capital			0.31B		0.27B	0.26B	0.25B	0.23B	0.22B	0.19B	0.17B	0.15B	0.16B	0.18B	0.02B	0.21B	0.41B	0.41B	0.38B	0.38B	0.03B	0.02B	0.26B	0.05B	0.02B	-0.02B	0.21B	-0.01B	-0.02B	-0.03B	0.04B	-0.03B	-0.01B	-0.03B	0.37B	0.39B	0.82B	0.85B	1.20B	1.40B	1.47B	1.50B	1.69B	1.57B	1.60B	1.61B	1.05B	0.74B	0.64B	0.59B	0.78B	0.71B	0.63B	0.60B	0.57B	0.49B	0.43B	0.32B	0.43B	0.34B	0.31B	0.71B	0.59B	0.48B	1.26B	1.25B
Asset Utilization Ratio						0.19	0.19	0.19	0.20	0.18	0.20	0.21	0.26	0.24	0.18	0.20	0.15	0.14	0.17	0.16	0.18	0.21	0.24	0.26	0.29	0.29	0.26	0.25	0.21	0.29	0.23	0.28	0.32	0.31	0.30	0.23	0.18	0.09	0.14	0.17	0.13	0.13	0.07	0.07	0.07	0.11	0.13	0.14	0.18	0.17	0.32	0.33	0.34	0.36	0.24	0.21	0.22	0.21	0.27	0.27	0.30	0.28	0.23	0.25	0.27	0.26
Leverage & Solvency
Interest Coverage Ratio	-0.21	-3.26	-3.59	-1.51	-5.73	-2.68	-4.67	-4.72	-4.09	-4.68	-3.64	-3.56	0.71	-4.72	-5.42	0.34	-1.65	-5.24	-4.07	-6.00	-1.34	-4.30	1.38	-1.03	4.89	-5.21	-6.73	-5.76	-5.08	1.65	4.14	1.71	0.55	1.04	-0.57	-0.30	-4.52	-1.65	0.94	10.48	-1.60	0.21	-11.35	-27.70	-21.20	-15.05	-9.31	-38.10	-30.96	-36.69	98.57	-27.10	-40.15	-27.65	-120.17	-70.99	-39.37	-34.09	-1.34	-36.02	-14.72	-35.73	-26.44	-35.75	33.99	-38.03
Debt to Equity			0.05		0.04	0.04	0.05	0.04	0.05	0.05	0.04	0.04	0.10	0.08	0.98	0.05	0.03	0.03	0.03	0.03	0.35	0.46	0.04	0.20	0.47	-0.45	0.06	-0.69	-0.41	-0.56	0.41	-0.50	-1.20	-1.98	0.17	0.15	0.07	0.09	0.06	0.05	0.05	0.04	0.04	0.04	0.04	0.04	0.50	0.18	0.21	0.23	0.08	0.09	0.10	0.11	0.03	0.02			0.22	0.15	0.17	0.07	0.09		1.00	1.02
Debt Ratio			0.02		0.02	0.02	0.02	0.02	0.02	0.02	0.02	0.01	0.03	0.03	0.02	0.02	0.02	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.02	0.02	0.01	0.03	0.05	0.05	0.05	0.03	0.03	0.03	0.03	0.03	0.02	0.02	0.02	0.02	0.02	0.15	0.05	0.05	0.05	0.02	0.03	0.03	0.03	0.01	0.00			0.03	0.02	0.02	0.01	0.02		0.21	0.21
Equity Ratio			0.46		0.43	0.44	0.44	0.45	0.40	0.37	0.35	0.32	0.33	0.35	0.02	0.36	0.51	0.46	0.45	0.45	0.03	0.02	0.27	0.05	0.02	-0.02	0.21	-0.02	-0.03	-0.03	0.04	-0.03	-0.03	-0.02	0.28	0.30	0.36	0.37	0.44	0.49	0.51	0.52	0.52	0.51	0.52	0.52	0.31	0.30	0.23	0.22	0.30	0.28	0.25	0.25	0.23	0.17	0.14	0.11	0.13	0.11	0.10	0.22	0.20	0.17	0.21	0.20
Times Interest Earned	-0.21	-3.26	-3.59	-1.51	-5.73	-2.68	-4.67	-4.72	-4.09	-4.68	-3.64	-3.56	0.71	-4.72	-5.42	0.34	-1.65	-5.24	-4.07	-6.00	-1.34	-4.30	1.38	-1.03	4.89	-5.21	-6.73	-5.76	-5.08	1.65	4.14	1.71	0.55	1.04	-0.57	-0.30	-4.52	-1.65	0.94	10.48	-1.60	0.21	-11.35	-27.70	-21.20	-15.05	-9.31	-38.10	-30.96	-36.69	98.57	-27.10	-40.15	-27.65	-120.17	-70.99	-39.37	-34.09	-1.34	-36.02	-14.72	-35.73	-26.44	-35.75	33.99	-38.03
Valuation
Enterprise Value	1.40B	1.28B	0.53B	0.98B	0.43B	0.34B	0.53B	0.47B	0.52B	0.31B	0.38B	0.54B	0.87B	1.07B	0.68B	1.35B	2.20B	3.66B	3.97B	4.44B	3.11B	3.98B	6.57B	6.29B	5.79B	4.04B	3.26B	3.51B	2.15B	3.74B	5.13B	4.11B	5.45B	5.38B	5.34B	4.58B	3.37B	5.25B	5.49B	9.16B	6.94B	6.36B	6.21B	4.41B	6.08B	4.52B	6.01B	4.51B	3.56B	2.75B	2.18B	3.20B	3.23B	4.30B	3.38B	2.76B	3.49B	4.27B	4.93B	4.11B	4.88B	3.37B	3.22B	2.65B	4.00B	8.19B
Market Capitalization	1.62B	1.43B	1.09B	1.08B	0.95B	0.83B	1.00B	0.90B	0.91B	0.68B	0.72B	0.88B	1.20B	1.42B	1.06B	1.72B	2.79B	4.33B	4.62B	5.07B	3.70B	4.57B	7.29B	6.98B	6.54B	4.85B	4.04B	4.22B	2.81B	4.43B	5.80B	4.97B	6.31B	6.30B	6.28B	5.53B	5.23B	7.08B	7.44B	11.23B	9.02B	8.42B	8.50B	6.58B	8.21B	6.63B	7.91B	6.33B	5.62B	4.73B	4.30B	5.25B	5.25B	6.28B	5.37B	5.11B	5.87B	6.50B	7.26B	6.32B	6.96B	5.86B	5.52B	4.80B	6.29B	10.43B
Return Ratios
Return on Sales				1.46%	-0.32%	-0.43%	-0.56%	-0.72%	-0.64%	-0.85%	-0.86%	-0.88%	-0.58%	-0.72%	-0.72%	-0.39%	-0.52%	-0.40%	-0.45%	-0.73%	-0.64%	-0.55%	-0.18%	-0.10%	0.08%	0.05%	-0.35%	-0.59%	-1.29%	-0.77%	-0.30%	0.04%	0.19%	0.14%	-0.03%	-0.10%	-0.27%	-0.47%	0.61%	0.67%	1.01%	1.08%	1.27%	0.70%	0.55%	0.18%	-1.39%	-1.60%	-1.29%	-1.49%	-0.04%	-0.01%	-0.03%	0.01%	-0.46%	-0.57%	-0.49%	-0.67%	-0.47%	-0.50%	-0.45%	-0.45%	-0.64%	-0.64%	-0.35%	-0.32%
Return on Capital Employed						-0.09%	-0.11%	-0.14%	-0.13%	-0.16%	-0.17%	-0.18%	-0.13%	-0.14%	-0.16%	-0.10%	-0.10%	-0.08%	-0.07%	-0.11%	-0.11%	-0.11%	-0.06%	-0.03%	0.03%	0.00%	-0.09%	-0.15%	-0.29%	-0.21%	-0.06%	0.03%	0.09%	0.08%	0.03%	0.01%	-0.03%	-0.04%	-0.03%	0.03%	0.04%	0.04%	0.13%	0.06%	0.05%	0.04%	-0.08%	-0.10%	-0.11%	-0.13%	-0.01%	0.00%	0.00%	0.01%	-0.19%	-0.19%	-0.18%	-0.22%	-0.14%	-0.15%	-0.15%	-0.14%	-0.17%	-0.18%	-0.13%	-0.13%
Return on Invested Capital														-0.36%	-0.63%					-0.19%	-0.36%	-2.86%	-0.24%	-0.11%			-0.65%						-4.04%	-3.73%	0.15%	0.02%	-0.08%	-0.09%					0.19%	0.10%	0.08%	0.04%					-0.04%			0.02%									-0.72%	-0.88%	-0.30%	-0.22%
Return on Assets						-0.08%	-0.11%	-0.14%	-0.12%	-0.15%	-0.17%	-0.19%	-0.15%	-0.17%	-0.13%	-0.08%	-0.08%	-0.05%	-0.08%	-0.11%	-0.12%	-0.12%	-0.04%	-0.03%	0.02%	0.01%	-0.09%	-0.15%	-0.27%	-0.22%	-0.07%	0.01%	0.06%	0.04%	-0.01%	-0.02%	-0.05%	-0.04%	0.09%	0.12%	0.13%	0.14%	0.09%	0.05%	0.04%	0.02%	-0.18%	-0.23%	-0.24%	-0.25%	-0.01%	0.00%	-0.01%	0.00%	-0.11%	-0.12%	-0.11%	-0.14%	-0.12%	-0.13%	-0.13%	-0.12%	-0.15%	-0.16%	-0.09%	-0.09%
Return on Equity						-0.19%	-0.25%	-0.30%	-0.29%	-0.39%	-0.47%	-0.55%	-0.47%	-0.51%	-0.72%	-0.40%	-0.18%	-0.11%	-0.17%	-0.26%	-0.49%	-4.51%	-0.28%	-0.16%	0.71%	62.59%	-0.97%	-1.46%	10.57%	6.89%	-9.21%	2.51%	-2.15%	-1.66%	-0.06%	-0.08%	-0.14%	-0.12%	0.21%	0.25%	0.26%	0.27%	0.18%	0.09%	0.08%	0.04%	-0.41%	-0.73%	-0.90%	-1.10%	-0.05%	-0.01%	-0.04%	0.01%	-0.46%	-0.62%	-0.68%	-1.10%	-1.05%	-1.13%	-1.31%	-0.78%	-0.73%	-0.86%	-0.49%	-0.41%

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Ionis Pharmaceuticals Ratios (2009-2025) | IONS

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