Ionis Pharmaceuticals (IONS) FCF Margin (2009 - 2026)

Ionis Pharmaceuticals' (IONS) quarterly FCF Margin came in at 331.01% in Q1 2026, down 20689.0% year-on-year from N/an in Q1 2025, and down 522.98% quarter-over-quarter from 53.13% in Q4 2025.

Ionis Pharmaceuticals (IONS) FCF Margin (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' FCF Margin history runs 18 years deep, the most recent figure standing at 331.01% for Q1 2026.

  • On a quarterly basis, FCF Margin fell 20689.0% year-over-year to 331.01% in Q1 2026; TTM through Mar 2026 was 151.33%, a 7393.0% decrease from a year earlier, with the FY2025 full-year figure at 28.51%, up 4895.0% from the prior year.
  • FCF Margin declined to 331.01% in Q1 2026 per IONS's latest filing, from 53.13% in the prior quarter.
  • Across five years, FCF Margin topped out at 6951.65% in Q2 2025 and bottomed at 331.01% in Q1 2026.
  • The 5-year median for FCF Margin is 62.51% (2024), against an average of 328.63%.
  • Across the five-year window, FCF Margin surged 700764 bps in 2025 and plunged 20689 bps in 2026, its largest moves.
  • Year by year, FCF Margin stood at 134.53% in 2022, then jumped by 108 bps to 10.38% in 2023, then tumbled by 702 bps to 62.51% in 2024, then grew by 15 bps to 53.13% in 2025, then tumbled by 523 bps to 331.01% in 2026.
  • Per Business Quant, the three latest IONS FCF Margin figures stand at 331.01% (Q1 2026), 53.13% (Q4 2025), and 87.23% (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) FCF Margin (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 10.45%
4 NuCana 279.75 Bn 279.75 Bn - -
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 43.35%
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 23.53%
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - -
10 Ionis Pharmaceuticals 9.21 Bn 7.29 Bn 243.11 Mn -331.01%

Historic Data

Download Data
DateValue
Mar 31, 2026 -331.01%
Dec 31, 2025 -53.13%
Sep 30, 2025 -87.23%
Jun 30, 2025 6,951.65%
Mar 31, 2025 -124.12%
Dec 31, 2024 -62.51%
Sep 30, 2024 -92.70%
Jun 30, 2024 -55.99%
Mar 31, 2024 -129.23%
Dec 31, 2023 10.38%
Sep 30, 2023 -77.09%
Jun 30, 2023 -58.05%
Mar 31, 2023 -110.68%
Dec 31, 2022 -134.53%
Sep 30, 2022 -18.76%
Jun 30, 2022 -16.02%
Mar 31, 2022 -24.21%
Dec 31, 2021 45.72%
Sep 30, 2021 -44.25%
Jun 30, 2021 -53.29%