Ionis Pharmaceuticals (IONS) FCF Margin (2009 - 2026)
Ionis Pharmaceuticals' (IONS) quarterly FCF Margin came in at 331.01% in Q1 2026, down 20689.0% year-on-year from N/an in Q1 2025, and down 522.98% quarter-over-quarter from 53.13% in Q4 2025.
Ionis Pharmaceuticals (IONS) FCF Margin (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' FCF Margin history runs 18 years deep, the most recent figure standing at 331.01% for Q1 2026.
- On a quarterly basis, FCF Margin fell 20689.0% year-over-year to 331.01% in Q1 2026; TTM through Mar 2026 was 151.33%, a 7393.0% decrease from a year earlier, with the FY2025 full-year figure at 28.51%, up 4895.0% from the prior year.
- FCF Margin declined to 331.01% in Q1 2026 per IONS's latest filing, from 53.13% in the prior quarter.
- Across five years, FCF Margin topped out at 6951.65% in Q2 2025 and bottomed at 331.01% in Q1 2026.
- The 5-year median for FCF Margin is 62.51% (2024), against an average of 328.63%.
- Across the five-year window, FCF Margin surged 700764 bps in 2025 and plunged 20689 bps in 2026, its largest moves.
- Year by year, FCF Margin stood at 134.53% in 2022, then jumped by 108 bps to 10.38% in 2023, then tumbled by 702 bps to 62.51% in 2024, then grew by 15 bps to 53.13% in 2025, then tumbled by 523 bps to 331.01% in 2026.
- Per Business Quant, the three latest IONS FCF Margin figures stand at 331.01% (Q1 2026), 53.13% (Q4 2025), and 87.23% (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 10.45% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 43.35% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 23.53% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | - |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Ionis Pharmaceuticals | 9.21 Bn | 7.29 Bn | 243.11 Mn | -331.01% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -331.01% |
| Dec 31, 2025 | -53.13% |
| Sep 30, 2025 | -87.23% |
| Jun 30, 2025 | 6,951.65% |
| Mar 31, 2025 | -124.12% |
| Dec 31, 2024 | -62.51% |
| Sep 30, 2024 | -92.70% |
| Jun 30, 2024 | -55.99% |
| Mar 31, 2024 | -129.23% |
| Dec 31, 2023 | 10.38% |
| Sep 30, 2023 | -77.09% |
| Jun 30, 2023 | -58.05% |
| Mar 31, 2023 | -110.68% |
| Dec 31, 2022 | -134.53% |
| Sep 30, 2022 | -18.76% |
| Jun 30, 2022 | -16.02% |
| Mar 31, 2022 | -24.21% |
| Dec 31, 2021 | 45.72% |
| Sep 30, 2021 | -44.25% |
| Jun 30, 2021 | -53.29% |