Ionis Pharmaceuticals (IONS) FCF Margin (2009 - 2026)

Ionis Pharmaceuticals (IONS) recorded quarterly FCF Margin of 331.01% in Q1 2026, down 323.29% quarter-over-quarter from 78.2% in Q4 2025, and down 20689.0% on a YoY basis from N/an in Q1 2025.

Ionis Pharmaceuticals (IONS) FCF Margin (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' FCF Margin history runs 18 years deep, the most recent figure standing at 331.01% for Q1 2026.

  • In Q1 2026, FCF Margin fell 20689.0% year-over-year to 331.01%; the TTM figure through Mar 2026 stood at 159.71% (down 8231.0% YoY), while the FY2025 annual figure was 33.91%, up 4355.0% from the prior year.
  • FCF Margin was 331.01% for Q1 2026 at Ionis Pharmaceuticals, down from 78.2% in the prior quarter.
  • In the past five years, FCF Margin ranged from a high of 6951.65% in Q2 2025 to a low of 331.01% in Q1 2026.
  • Historically, FCF Margin has averaged 327.59% across 5 years, with a median of 77.09% in 2023.
  • The sharpest annual moves came in 2025 and 2026: FCF Margin soared 700764 bps in 2025, then plunged 20689 bps in 2026.
  • A 5-year view of FCF Margin shows it stood at 134.53% in 2022, then surged by 113 bps to 17.66% in 2023, then sank by 454 bps to 62.51% in 2024, then fell by 25 bps to 78.2% in 2025, then slumped by 323 bps to 331.01% in 2026.
  • The last three FCF Margin figures came in at 331.01% (Q1 2026), 78.2% (Q4 2025), and 87.23% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) FCF Margin (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -3.98%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 43.35%
9 Abivax 91.96 Bn 91.96 Bn - -
10 Ionis Pharmaceuticals 12.23 Bn 10.31 Bn 243.11 Mn -331.01%

Historic Data

Download Data
DateValue
Mar 31, 2026 -331.01%
Dec 31, 2025 -78.20%
Sep 30, 2025 -87.23%
Jun 30, 2025 6,951.65%
Mar 31, 2025 -124.12%
Dec 31, 2024 -62.51%
Sep 30, 2024 -92.70%
Jun 30, 2024 -55.99%
Mar 31, 2024 -129.23%
Dec 31, 2023 17.66%
Sep 30, 2023 -77.09%
Jun 30, 2023 -58.05%
Mar 31, 2023 -110.68%
Dec 31, 2022 -134.53%
Sep 30, 2022 -18.76%
Jun 30, 2022 -16.02%
Mar 31, 2022 -24.21%
Dec 31, 2021 45.72%
Sep 30, 2021 -44.25%
Jun 30, 2021 -53.29%