Ionis Pharmaceuticals (IONS) EBT Margin (2009 - 2026)
Ionis Pharmaceuticals' (IONS) quarterly EBT Margin came in at 37.51% in Q1 2026, up 7405.0% year-on-year from 0.5% in Q1 2025, and up 66.54% quarter-over-quarter from 112.09% in Q4 2025.
Ionis Pharmaceuticals (IONS) EBT Margin (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' EBT Margin history runs 18 years deep, the most recent figure standing at 37.51% for Q1 2026.
- On a quarterly basis, EBT Margin rose 7405.0% year-over-year to 37.51% in Q1 2026; TTM through Mar 2026 was 53.46%, a 1135.0% increase from a year earlier, with the FY2025 full-year figure at 40.22%, up 2511.0% from the prior year.
- EBT Margin grew to 37.51% in Q1 2026 per IONS's latest filing, from 112.09% in the prior quarter.
- Across five years, EBT Margin topped out at 6176.55% in Q2 2025 and bottomed at 119.44% in Q1 2024.
- The 5-year median for EBT Margin is 47.53% (2024), against an average of 307.41%.
- Across the five-year window, EBT Margin plunged 14982 bps in 2024 and surged 620594 bps in 2025, its largest moves.
- Year by year, EBT Margin stood at 29.19% in 2022, then soared by 450 bps to 102.29% in 2023, then slumped by 146 bps to 47.53% in 2024, then plunged by 136 bps to 112.09% in 2025, then surged by 67 bps to 37.51% in 2026.
- Per Business Quant, the three latest IONS EBT Margin figures stand at 37.51% (Q1 2026), 112.09% (Q4 2025), and 81.93% (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 17.13% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 41.95% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 23.05% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 34.77% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Ionis Pharmaceuticals | 9.21 Bn | 7.29 Bn | 243.11 Mn | -37.51% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -37.51% |
| Dec 31, 2025 | -112.09% |
| Sep 30, 2025 | -81.93% |
| Jun 30, 2025 | 6,176.55% |
| Mar 31, 2025 | -111.56% |
| Dec 31, 2024 | -47.53% |
| Sep 30, 2024 | -107.69% |
| Jun 30, 2024 | -29.39% |
| Mar 31, 2024 | -119.44% |
| Dec 31, 2023 | 102.29% |
| Sep 30, 2023 | -97.64% |
| Jun 30, 2023 | -41.11% |
| Mar 31, 2023 | -86.53% |
| Dec 31, 2022 | -29.19% |
| Sep 30, 2022 | -29.24% |
| Jun 30, 2022 | -76.89% |
| Mar 31, 2022 | -45.15% |
| Dec 31, 2021 | 57.93% |
| Sep 30, 2021 | -62.94% |
| Jun 30, 2021 | -64.05% |