Ionis Pharmaceuticals IONS
NASDAQ IONS
$58.09 -0.04 (-0.07%)
As of: Sep 4, 2026 · 3:59 PM EDT

Ionis Pharmaceuticals (IONS) EBT Margin (2009 - 2026)

Ionis Pharmaceuticals (IONS) posted quarterly EBT Margin of 42.31% for Q2 2026, down 6964.0% year-over-year from 0.62% in Q2 2025, and up 77.08% quarter-over-quarter from 184.62% in Q1 2026.

Analysis

Ionis Pharmaceuticals (IONS) EBT Margin (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' EBT Margin history runs 18 years deep, the most recent figure standing at 42.31% for Q2 2026.

  • In Q2 2026, EBT Margin fell 6964.0% year-over-year to 42.31%; the TTM figure through Jun 2026 stood at 83.12% (down 5399.0% YoY), while the FY2025 annual figure was 40.39%, up 2494.0% from the prior year.
  • EBT Margin for Q2 2026 stood at 42.31%, up from 184.62% in the prior quarter.
  • The five-year high for EBT Margin was 27.33% in Q2 2025, with the low at 184.62% in Q1 2026.
  • The 5-year median for EBT Margin is 62.21% (2024), against an average of 67.62%.
  • The sharpest annual moves came in 2022 and 2025: EBT Margin plunged 8045 bps in 2022, then jumped 5672 bps in 2025.
  • Ionis Pharmaceuticals' EBT Margin stood at 29.52% in 2022, then surged by 96 bps to 1.08% in 2023, then sank by 4295 bps to 47.53% in 2024, then tumbled by 137 bps to 112.87% in 2025, then soared by 63 bps to 42.31% in 2026.
  • Business Quant data shows IONS's EBT Margin at 42.31% in Q2 2026, 184.62% in Q1 2026, and 112.87% in Q4 2025.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBT Margin (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 41.75%
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn 35.61%
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn 35.78%
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn -528.97%
5 Revolution Medicines 44.33 Bn 44.33 Bn - -
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 18.33%
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn 13.77%
8 Royalty Pharma 28.45 Bn 27.61 Bn - 12.09%
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn -2.67%
10 Ionis Pharmaceuticals 9.60 Bn 7.55 Bn 265.21 Mn -42.31%
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -42.31%
Mar 31, 2026 -37.51%
Dec 31, 2025 -112.87%
Sep 30, 2025 -81.93%
Jun 30, 2025 27.33%
Mar 31, 2025 -111.56%
Dec 31, 2024 -47.53%
Sep 30, 2024 -107.69%
Jun 30, 2024 -29.39%
Mar 31, 2024 -119.44%
Dec 31, 2023 -1.08%
Sep 30, 2023 -97.64%
Jun 30, 2023 -41.11%
Mar 31, 2023 -86.53%
Dec 31, 2022 -29.52%
Sep 30, 2022 -29.24%
Jun 30, 2022 -76.89%
Mar 31, 2022 -45.15%
Dec 31, 2021 50.93%
Sep 30, 2021 -62.94%