Ionis Pharmaceuticals (IONS) EBT Margin (2009 - 2026)
Ionis Pharmaceuticals (IONS) posted quarterly EBT Margin of 42.31% for Q2 2026, down 6964.0% year-over-year from 0.62% in Q2 2025, and up 77.08% quarter-over-quarter from 184.62% in Q1 2026.
Ionis Pharmaceuticals (IONS) EBT Margin (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' EBT Margin history runs 18 years deep, the most recent figure standing at 42.31% for Q2 2026.
- In Q2 2026, EBT Margin fell 6964.0% year-over-year to 42.31%; the TTM figure through Jun 2026 stood at 83.12% (down 5399.0% YoY), while the FY2025 annual figure was 40.39%, up 2494.0% from the prior year.
- EBT Margin for Q2 2026 stood at 42.31%, up from 184.62% in the prior quarter.
- The five-year high for EBT Margin was 27.33% in Q2 2025, with the low at 184.62% in Q1 2026.
- The 5-year median for EBT Margin is 62.21% (2024), against an average of 67.62%.
- The sharpest annual moves came in 2022 and 2025: EBT Margin plunged 8045 bps in 2022, then jumped 5672 bps in 2025.
- Ionis Pharmaceuticals' EBT Margin stood at 29.52% in 2022, then surged by 96 bps to 1.08% in 2023, then sank by 4295 bps to 47.53% in 2024, then tumbled by 137 bps to 112.87% in 2025, then soared by 63 bps to 42.31% in 2026.
- Business Quant data shows IONS's EBT Margin at 42.31% in Q2 2026, 184.62% in Q1 2026, and 112.87% in Q4 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 41.75% |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 35.61% |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 34.77% |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | - |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 18.33% |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | -94.22% |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 12.09% |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 13.77% |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | -2.67% |
| 10 | Ionis Pharmaceuticals | 9.48 Bn | 7.43 Bn | 265.21 Mn | -42.31% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -42.31% |
| Mar 31, 2026 | -184.62% |
| Dec 31, 2025 | -112.87% |
| Sep 30, 2025 | -81.93% |
| Jun 30, 2025 | 27.33% |
| Mar 31, 2025 | -111.56% |
| Dec 31, 2024 | -47.53% |
| Sep 30, 2024 | -107.69% |
| Jun 30, 2024 | -29.39% |
| Mar 31, 2024 | -119.44% |
| Dec 31, 2023 | -1.08% |
| Sep 30, 2023 | -97.64% |
| Jun 30, 2023 | -41.11% |
| Mar 31, 2023 | -86.53% |
| Dec 31, 2022 | -29.52% |
| Sep 30, 2022 | -29.24% |
| Jun 30, 2022 | -76.89% |
| Mar 31, 2022 | -45.15% |
| Dec 31, 2021 | 50.93% |
| Sep 30, 2021 | -62.94% |