Ionis Pharmaceuticals (IONS) EBT Margin (2009 - 2026)

Ionis Pharmaceuticals (IONS) recorded quarterly EBT Margin of 37.51% in Q1 2026, up 66.77% quarter-over-quarter from 112.87% in Q4 2025, and up 7405.0% on a YoY basis from 0.5% in Q1 2025.

Ionis Pharmaceuticals (IONS) EBT Margin (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' EBT Margin history runs 18 years deep, the most recent figure standing at 37.51% for Q1 2026.

  • In Q1 2026, EBT Margin rose 7405.0% year-over-year to 37.51%; the TTM figure through Mar 2026 stood at 53.72% (up 1109.0% YoY), while the FY2025 annual figure was 40.39%, up 2494.0% from the prior year.
  • EBT Margin was 37.51% for Q1 2026 at Ionis Pharmaceuticals, up from 112.87% in the prior quarter.
  • In the past five years, EBT Margin ranged from a high of 6176.55% in Q2 2025 to a low of 119.44% in Q1 2024.
  • Historically, EBT Margin has averaged 301.28% across 5 years, with a median of 47.53% in 2024.
  • The sharpest annual moves came in 2022 and 2025: EBT Margin sank 8045 bps in 2022, then soared 620594 bps in 2025.
  • A 5-year view of EBT Margin shows it stood at 29.52% in 2022, then soared by 97 bps to 0.85% in 2023, then tumbled by 5474 bps to 47.53% in 2024, then plunged by 137 bps to 112.87% in 2025, then jumped by 67 bps to 37.51% in 2026.
  • The last three EBT Margin figures came in at 37.51% (Q1 2026), 112.87% (Q4 2025), and 81.93% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBT Margin (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 6.40%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 41.95%
9 Abivax 91.96 Bn 91.96 Bn - -
10 Ionis Pharmaceuticals 12.23 Bn 10.31 Bn 243.11 Mn -37.51%

Historic Data

Download Data
DateValue
Mar 31, 2026 -37.51%
Dec 31, 2025 -112.87%
Sep 30, 2025 -81.93%
Jun 30, 2025 6,176.55%
Mar 31, 2025 -111.56%
Dec 31, 2024 -47.53%
Sep 30, 2024 -107.69%
Jun 30, 2024 -29.39%
Mar 31, 2024 -119.44%
Dec 31, 2023 -0.85%
Sep 30, 2023 -97.64%
Jun 30, 2023 -41.11%
Mar 31, 2023 -86.53%
Dec 31, 2022 -29.52%
Sep 30, 2022 -29.24%
Jun 30, 2022 -76.89%
Mar 31, 2022 -45.15%
Dec 31, 2021 50.93%
Sep 30, 2021 -62.94%
Jun 30, 2021 -64.05%