Ionis Pharmaceuticals (IONS) EBT Margin (2009 - 2026)
Ionis Pharmaceuticals (IONS) recorded EBT Margin of -42.31% in Q2 2026, down 69.64 percentage points from 27.33% a year earlier and down 4.80 percentage points from the prior quarter.
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Analysis
Ionis Pharmaceuticals (IONS) EBT Margin (2009 - 2026) Analysis & Trends
On a TTM basis, Ionis Pharmaceuticals' EBT Margin came in at -64.30% as of Jun 30, 2026, down 35.23 percentage points year-over-year; for FY2025, it was -40.22%, up 25.02 percentage points from FY2024.
- Annual EBT Margin has a five-year change of -21.77 percentage points (FY2020 to FY2025).
- Across earlier years, EBT Margin came in at -65.25% in FY2024 (-22.84 pp), -42.40% in FY2023 (+1.52 pp), -43.92% in FY2022 (-40.33 pp) and -3.60% in FY2021 (+14.85 pp).
- Quarterly EBT Margin has ranged from -119.44% in Q1 2024 to 51.12% in Q4 2021 over the past five years.
- On a year-over-year basis, EBT Margin rose in four of the last eight quarters, with an average year-over-year change of -3.31 percentage points.
- Peak year-over-year performance for EBT Margin in the last five years was a gain of 74.05 percentage points in Q1 2026, against a drop of 80.30 percentage points in Q4 2022 at the low end.
- Per Business Quant, the preceding three quarters came in at -37.51% (Q1 2026), -112.09% (Q4 2025) and -81.93% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 26.66% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 25.18% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -4.11% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 29.63% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 18.19% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 27.53% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -131.41% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | -4.34% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 41.75% |
| 10 | Ionis Pharmaceuticals | 7.55 Bn | -1.34 Bn | 265.21 Mn | -42.31% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -42.31% |
| Mar 31, 2026 | -37.51% |
| Dec 31, 2025 | -112.09% |
| Sep 30, 2025 | -81.93% |
| Jun 30, 2025 | 27.33% |
| Mar 31, 2025 | -111.56% |
| Dec 31, 2024 | -47.24% |
| Sep 30, 2024 | -107.69% |
| Jun 30, 2024 | -29.39% |
| Mar 31, 2024 | -119.44% |
| Dec 31, 2023 | -0.85% |
| Sep 30, 2023 | -97.64% |
| Jun 30, 2023 | -41.11% |
| Mar 31, 2023 | -86.53% |
| Dec 31, 2022 | -29.19% |
| Sep 30, 2022 | -29.24% |
| Jun 30, 2022 | -76.89% |
| Mar 31, 2022 | -45.15% |
| Dec 31, 2021 | 51.12% |
| Sep 30, 2021 | -62.94% |
API Access
Ionis Pharmaceuticals EBT Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebt-margin&ticker=IONS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebt-margin", "ticker": "IONS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebt-margin&ticker=IONS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();