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Ionis Pharmaceuticals (IONS) Gross Margin: 2009-2025

Historic Gross Margin for Ionis Pharmaceuticals (IONS) over the last 17 years, with Sep 2025 value amounting to 98.51%.

  • Ionis Pharmaceuticals' Gross Margin fell 69.00% to 98.51% in Q3 2025 from the same period last year, while for Sep 2025 it was 98.51%, marking a year-over-year decrease of 18.00%. This contributed to the annual value of 98.41% for FY2024, which is 43.00% down from last year.
  • Per Ionis Pharmaceuticals' latest filing, its Gross Margin stood at 98.51% for Q3 2025, which was up 0.00% from 98.51% recorded in Q2 2025.
  • Ionis Pharmaceuticals' 5-year Gross Margin high stood at 99.49% for Q4 2021, and its period low was 96.45% during Q2 2022.
  • For the 3-year period, Ionis Pharmaceuticals' Gross Margin averaged around 98.63%, with its median value being 98.51% (2025).
  • Per our database at Business Quant, Ionis Pharmaceuticals' Gross Margin spiked by 2,082bps in 2021 and then tumbled by 192bps in 2022.
  • Over the past 5 years, Ionis Pharmaceuticals' Gross Margin (Quarterly) stood at 99.49% in 2021, then crashed by 192bps to 97.57% in 2022, then skyrocketed by 148bps to 99.06% in 2023, then slumped by 75bps to 98.31% in 2024, then plummeted by 69bps to 98.51% in 2025.
  • Its last three reported values are 98.51% in Q3 2025, 98.51% for Q2 2025, and 98.89% during Q1 2025.