Ionis Pharmaceuticals (IONS) Gross Margin (2018 - 2026)
Ionis Pharmaceuticals (IONS) recorded Gross Margin of 98.98% in Q2 2026, down 0.10 percentage points from 99.08% a year earlier but up 0.19 percentage points from the prior quarter.
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Analysis
Ionis Pharmaceuticals (IONS) Gross Margin (2018 - 2026) Analysis & Trends
On a TTM basis, Ionis Pharmaceuticals' Gross Margin came in at 98.17% as of Jun 30, 2026, down 0.72 percentage points year-over-year; for FY2025, it was 98.31%, down 0.10 percentage points from FY2024.
- Annual Gross Margin has a five-year change of -0.05 percentage points (FY2020 to FY2025).
- Across earlier years, Gross Margin came in at 98.41% in FY2024 (-0.43 pp), 98.84% in FY2023 (+1.24 pp), 97.60% in FY2022 (-1.07 pp) and 98.66% in FY2021 (+0.30 pp).
- Quarterly Gross Margin has ranged from 96.09% in Q4 2025 to 99.49% in Q4 2021 over the past five years.
- On a year-over-year basis, Gross Margin has declined for four consecutive quarters, with an average year-over-year change of -0.19 percentage points over the last eight quarters.
- Peak year-over-year performance for Gross Margin in the last five years was a gain of 2.20 percentage points in Q2 2023, against a drop of 2.22 percentage points in Q4 2025 at the low end.
- Per Business Quant, the preceding three quarters came in at 98.79% (Q1 2026), 96.09% (Q4 2025) and 98.51% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 68.19% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 74.74% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | 73.54% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 78.02% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 83.60% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 72.04% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | 79.76% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 72.78% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 85.33% |
| 10 | Ionis Pharmaceuticals | 7.55 Bn | -1.34 Bn | 265.21 Mn | 98.98% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 98.98% |
| Mar 31, 2026 | 98.79% |
| Dec 31, 2025 | 96.09% |
| Sep 30, 2025 | 98.51% |
| Jun 30, 2025 | 99.08% |
| Mar 31, 2025 | 98.89% |
| Dec 31, 2024 | 98.31% |
| Sep 30, 2024 | 99.20% |
| Jun 30, 2024 | 98.15% |
| Mar 31, 2024 | 98.20% |
| Dec 31, 2023 | 99.06% |
| Sep 30, 2023 | 98.48% |
| Jun 30, 2023 | 98.65% |
| Mar 31, 2023 | 98.97% |
| Dec 31, 2022 | 97.57% |
| Sep 30, 2022 | 99.05% |
| Jun 30, 2022 | 96.45% |
| Mar 31, 2022 | 97.06% |
| Dec 31, 2021 | 99.49% |
| Sep 30, 2021 | 97.69% |
API Access
Ionis Pharmaceuticals Gross Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=gross-margin&ticker=IONS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "gross-margin", "ticker": "IONS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=gross-margin&ticker=IONS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();