Ionis Pharmaceuticals (IONS) EBIT Margin (2009 - 2026)
Ionis Pharmaceuticals (IONS) reported EBIT Margin of -38.18% for Q2 2026, down 69.11 percentage points from 30.93% a year earlier but up 9.54 percentage points from the prior quarter.
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Analysis
Ionis Pharmaceuticals (IONS) EBIT Margin (2009 - 2026) Analysis & Trends
Over the twelve months ended Jun 30, 2026, Ionis Pharmaceuticals' EBIT Margin came in at -68.00%, down 39.77 percentage points year-over-year; for FY2025, it came in at -40.45%, up 26.93 percentage points from FY2024.
- EBIT Margin has a five-year change of -16.85 percentage points (FY2020 to FY2025).
- By year, EBIT Margin came in at -67.37% in FY2024 (-22.46 pp), -44.91% in FY2023 (+24.93 pp), -69.84% in FY2022 (-66.11 pp) and -3.72% in FY2021 (+19.87 pp).
- Five-year quarterly EBIT Margin spans a low of -136.95% in Q4 2022 and a high of 50.14% in Q4 2021.
- Year over year, EBIT Margin gained in four of the last eight quarters, with an average year-over-year change of -4.74 percentage points.
- The high point for year-over-year EBIT Margin in five years was Q4 2023 (a gain of 135.07 percentage points); the low point was Q4 2022 (a drop of 187.09 percentage points).
- Per Business Quant data, the three quarters before Q2 2026 came in at -47.72% (Q1 2026), -105.47% (Q4 2025) and -102.21% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBIT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Ionis Pharmaceuticals | 7.55 Bn | -1.34 Bn | 265.21 Mn | -38.18% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -38.18% |
| Mar 31, 2026 | -47.72% |
| Dec 31, 2025 | -105.47% |
| Sep 30, 2025 | -102.21% |
| Jun 30, 2025 | 30.93% |
| Mar 31, 2025 | -111.59% |
| Dec 31, 2024 | -48.91% |
| Sep 30, 2024 | -111.09% |
| Jun 30, 2024 | -29.34% |
| Mar 31, 2024 | -125.12% |
| Dec 31, 2023 | -1.89% |
| Sep 30, 2023 | -99.35% |
| Jun 30, 2023 | -47.87% |
| Mar 31, 2023 | -87.45% |
| Dec 31, 2022 | -136.95% |
| Sep 30, 2022 | -37.03% |
| Jun 30, 2022 | -63.92% |
| Mar 31, 2022 | -40.52% |
| Dec 31, 2021 | 50.14% |
| Sep 30, 2021 | -64.50% |
API Access
Ionis Pharmaceuticals EBIT Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebit-margin&ticker=IONS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebit-margin", "ticker": "IONS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebit-margin&ticker=IONS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();