Ionis Pharmaceuticals (IONS) Net Margin (2009 - 2026)
Ionis Pharmaceuticals' (IONS) quarterly Net Margin came in at 37.6% in Q1 2026, up 7405.0% year-on-year from 0.5% in Q1 2025, and down 161.88% quarter-over-quarter from 60.76% in Q4 2025.
Ionis Pharmaceuticals (IONS) Net Margin (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' Net Margin history runs 18 years deep, the most recent figure standing at 37.6% for Q1 2026.
- On a quarterly basis, Net Margin rose 7405.0% year-over-year to 37.6% in Q1 2026; TTM through Mar 2026 was 4.27%, a 6742.0% increase from a year earlier, with the FY2025 full-year figure at 41.51%, up 2214.0% from the prior year.
- Net Margin slipped to 37.6% in Q1 2026 per IONS's latest filing, from 60.76% in the prior quarter.
- Across five years, Net Margin topped out at 6177.55% in Q2 2025 and bottomed at 119.5% in Q1 2024.
- The 5-year median for Net Margin is 45.25% (2023), against an average of 316.95%.
- Across the five-year window, Net Margin plunged 14410 bps in 2024 and jumped 620697 bps in 2025, its largest moves.
- Year by year, Net Margin stood at 24.76% in 2022, then jumped by 505 bps to 100.28% in 2023, then slumped by 144 bps to 43.82% in 2024, then jumped by 239 bps to 60.76% in 2025, then plunged by 162 bps to 37.6% in 2026.
- Per Business Quant, the three latest IONS Net Margin figures stand at 37.6% (Q1 2026), 60.76% (Q4 2025), and 82.06% (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 15.02% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 34.53% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 20.17% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 30.33% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Ionis Pharmaceuticals | 9.21 Bn | 7.29 Bn | 243.11 Mn | -37.60% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -37.60% |
| Dec 31, 2025 | 60.76% |
| Sep 30, 2025 | -82.06% |
| Jun 30, 2025 | 6,177.55% |
| Mar 31, 2025 | -111.64% |
| Dec 31, 2024 | -43.82% |
| Sep 30, 2024 | -104.98% |
| Jun 30, 2024 | -29.42% |
| Mar 31, 2024 | -119.50% |
| Dec 31, 2023 | 100.28% |
| Sep 30, 2023 | -102.22% |
| Jun 30, 2023 | -45.25% |
| Mar 31, 2023 | -95.26% |
| Dec 31, 2022 | -24.76% |
| Sep 30, 2022 | -29.41% |
| Jun 30, 2022 | -78.58% |
| Mar 31, 2022 | -45.92% |
| Dec 31, 2021 | 57.85% |
| Sep 30, 2021 | -61.96% |
| Jun 30, 2021 | -64.31% |