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Asset Utilization RatioAssets AverageDebt RatioDebt to EquityEBIT MarginEBITDA MarginEBT MarginEnterprise ValueEquity AverageEquity RatioFCF MarginGross MarginInterest Coverage RatioInventory AverageInvested CapitalNet MarginOperating MarginReturn on AssetsReturn on Capital EmployedReturn on EquityReturn on Invested CapitalReturn on SalesTimes Interest Earned

Ionis Pharmaceuticals (IONS) Net Margin (2016 - 2025)

Ionis Pharmaceuticals (IONS) has 17 years of Net Margin data on record, last reported at 4752.29% in Q4 2025.

  • For Q4 2025, Net Margin rose 479864.0% year-over-year to 4752.29%; the TTM value through Dec 2025 reached 67.92%, up 2679.0%, while the annual FY2025 figure was 2209.4%, 227386.0% up from the prior year.
  • Net Margin reached 4752.29% in Q4 2025 per IONS's latest filing, up from 82.06% in the prior quarter.
  • Across five years, Net Margin topped out at 4752.29% in Q4 2025 and bottomed at 220883.33% in Q2 2024.
  • Average Net Margin over 5 years is 10933.22%, with a median of 71.47% recorded in 2021.
  • Peak YoY movement for Net Margin: crashed -22083808bps in 2024, then surged 22092778bps in 2025.
  • A 5-year view of Net Margin shows it stood at 424.22% in 2021, then plummeted by -108bps to 34.54% in 2022, then surged by 390bps to 100.28% in 2023, then crashed by -146bps to 46.35% in 2024, then soared by 10354bps to 4752.29% in 2025.
  • Per Business Quant database, its latest 3 readings for Net Margin were 4752.29% in Q4 2025, 82.06% in Q3 2025, and 44.44% in Q2 2025.