Ionis Pharmaceuticals (IONS) Net Margin (2009 - 2026)
Ionis Pharmaceuticals (IONS) posted quarterly Net Margin of 42.79% for Q2 2026, down 7012.0% year-over-year from 0.62% in Q2 2025, and up 76.88% quarter-over-quarter from 185.06% in Q1 2026.
Ionis Pharmaceuticals (IONS) Net Margin (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' Net Margin history runs 18 years deep, the most recent figure standing at 42.79% for Q2 2026.
- In Q2 2026, Net Margin fell 7012.0% year-over-year to 42.79%; the TTM figure through Jun 2026 stood at 31.3% (down 1240.0% YoY), while the FY2025 annual figure was 31.94%, up 1969.0% from the prior year.
- Net Margin for Q2 2026 stood at 42.79%, up from 185.06% in the prior quarter.
- The five-year high for Net Margin was 60.76% in Q4 2025, with the low at 185.06% in Q1 2026.
- The 5-year median for Net Margin is 45.59% (2022), against an average of 52.97%.
- The sharpest annual moves came in 2025 and 2026: Net Margin jumped 6719 bps in 2025, then plunged 7341 bps in 2026.
- Ionis Pharmaceuticals' Net Margin stood at 8.54% in 2022, then jumped by 233 bps to 28.49% in 2023, then plunged by 123 bps to 6.43% in 2024, then soared by 1045 bps to 60.76% in 2025, then slumped by 170 bps to 42.79% in 2026.
- Business Quant data shows IONS's Net Margin at 42.79% in Q2 2026, 185.06% in Q1 2026, and 60.76% in Q4 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 32.99% |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 30.23% |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 30.33% |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | - |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 13.90% |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | 30.98% |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 12.09% |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 12.74% |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | -3.12% |
| 10 | Ionis Pharmaceuticals | 9.48 Bn | 7.43 Bn | 265.21 Mn | -42.79% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -42.79% |
| Mar 31, 2026 | -185.06% |
| Dec 31, 2025 | 60.76% |
| Sep 30, 2025 | -82.06% |
| Jun 30, 2025 | 27.33% |
| Mar 31, 2025 | -111.64% |
| Dec 31, 2024 | -6.43% |
| Sep 30, 2024 | -104.98% |
| Jun 30, 2024 | -29.42% |
| Mar 31, 2024 | -119.52% |
| Dec 31, 2023 | 28.49% |
| Sep 30, 2023 | -102.22% |
| Jun 30, 2023 | -45.27% |
| Mar 31, 2023 | -95.26% |
| Dec 31, 2022 | 8.54% |
| Sep 30, 2022 | -29.42% |
| Jun 30, 2022 | -78.61% |
| Mar 31, 2022 | -45.92% |
| Dec 31, 2021 | 47.81% |
| Sep 30, 2021 | -61.96% |