Ionis Pharmaceuticals (IONS) EBITDA Margin (2009 - 2026)
Ionis Pharmaceuticals' (IONS) quarterly EBITDA Margin came in at 47.72% in Q1 2026, up 6387.0% year-on-year from 0.74% in Q1 2025, and up 54.76% quarter-over-quarter from 105.47% in Q4 2025.
Ionis Pharmaceuticals (IONS) EBITDA Margin (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' EBITDA Margin history runs 18 years deep, the most recent figure standing at 47.72% for Q1 2026.
- On a quarterly basis, EBITDA Margin rose 6387.0% year-over-year to 47.72% in Q1 2026; TTM through Mar 2026 was 57.92%, a 794.0% increase from a year earlier, with the FY2025 full-year figure at 40.45%, up 2693.0% from the prior year.
- EBITDA Margin improved to 47.72% in Q1 2026 per IONS's latest filing, from 105.47% in the prior quarter.
- Across five years, EBITDA Margin topped out at 6990.8% in Q2 2025 and bottomed at 136.95% in Q4 2022.
- The 5-year median for EBITDA Margin is 63.92% (2022), against an average of 340.85%.
- Across the five-year window, EBITDA Margin plunged 18709 bps in 2022 and surged 702014 bps in 2025, its largest moves.
- Year by year, EBITDA Margin stood at 136.95% in 2022, then soared by 99 bps to 1.89% in 2023, then tumbled by 2493 bps to 48.91% in 2024, then plunged by 116 bps to 105.47% in 2025, then jumped by 55 bps to 47.72% in 2026.
- Per Business Quant, the three latest IONS EBITDA Margin figures stand at 47.72% (Q1 2026), 105.47% (Q4 2025), and 102.21% (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 16.51% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 38.10% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 17.83% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 31.68% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Ionis Pharmaceuticals | 9.21 Bn | 7.29 Bn | 243.11 Mn | -47.72% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -47.72% |
| Dec 31, 2025 | -105.47% |
| Sep 30, 2025 | -102.21% |
| Jun 30, 2025 | 6,990.80% |
| Mar 31, 2025 | -111.59% |
| Dec 31, 2024 | -48.91% |
| Sep 30, 2024 | -111.09% |
| Jun 30, 2024 | -29.34% |
| Mar 31, 2024 | -125.12% |
| Dec 31, 2023 | -1.89% |
| Sep 30, 2023 | -99.35% |
| Jun 30, 2023 | -47.87% |
| Mar 31, 2023 | -87.45% |
| Dec 31, 2022 | -136.95% |
| Sep 30, 2022 | -37.03% |
| Jun 30, 2022 | -63.92% |
| Mar 31, 2022 | -40.52% |
| Dec 31, 2021 | 50.14% |
| Sep 30, 2021 | -64.50% |
| Jun 30, 2021 | -58.03% |