Ionis Pharmaceuticals (IONS) Operating Margin (2009 - 2026)
Ionis Pharmaceuticals (IONS) posted Operating Margin of -38.18% for Q2 2026, down 69.11 percentage points from 30.93% a year earlier but up 9.54 percentage points from the prior quarter.
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Analysis
Ionis Pharmaceuticals (IONS) Operating Margin (2009 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Operating Margin at Ionis Pharmaceuticals was -68.00%, down 39.77 percentage points year-over-year; for FY2025, it was -40.45%, up 26.93 percentage points from FY2024.
- Annual Operating Margin shows a five-year change of -16.85 percentage points (FY2020 to FY2025).
- In prior years, Ionis Pharmaceuticals' Operating Margin was -67.37% in FY2024 (-22.46 pp), -44.91% in FY2023 (+24.93 pp), -69.84% in FY2022 (-66.11 pp) and -3.72% in FY2021 (+19.87 pp).
- Quarterly Operating Margin has run from a low of -136.95% in Q4 2022 to a high of 50.14% in Q4 2021 over five years.
- On a year-over-year basis, Operating Margin increased in four of the last eight quarters, with an average year-over-year change of -4.74 percentage points.
- The strongest year-over-year quarter for Operating Margin in the past five years was Q4 2023, with a gain of 135.07 percentage points; the weakest was Q4 2022, with a drop of 187.09 percentage points.
- According to Business Quant data, Operating Margin for the three prior quarters was -47.72% (Q1 2026), -105.47% (Q4 2025) and -102.21% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Ionis Pharmaceuticals | 7.55 Bn | -1.34 Bn | 265.21 Mn | -38.18% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -38.18% |
| Mar 31, 2026 | -47.72% |
| Dec 31, 2025 | -105.47% |
| Sep 30, 2025 | -102.21% |
| Jun 30, 2025 | 30.93% |
| Mar 31, 2025 | -111.59% |
| Dec 31, 2024 | -48.91% |
| Sep 30, 2024 | -111.09% |
| Jun 30, 2024 | -29.34% |
| Mar 31, 2024 | -125.12% |
| Dec 31, 2023 | -1.89% |
| Sep 30, 2023 | -99.35% |
| Jun 30, 2023 | -47.87% |
| Mar 31, 2023 | -87.45% |
| Dec 31, 2022 | -136.95% |
| Sep 30, 2022 | -37.03% |
| Jun 30, 2022 | -63.92% |
| Mar 31, 2022 | -40.52% |
| Dec 31, 2021 | 50.14% |
| Sep 30, 2021 | -64.50% |
API Access
Ionis Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=IONS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "IONS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=IONS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();