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Ionis Pharmaceuticals (IONS) Operating Margin: 2009-2025

Historic Operating Margin for Ionis Pharmaceuticals (IONS) over the last 17 years, with Sep 2025 value amounting to -102.21%.

  • Ionis Pharmaceuticals' Operating Margin rose 888.00% to -102.21% in Q3 2025 from the same period last year, while for Sep 2025 it was -35.07%, marking a year-over-year increase of 1105.00%. This contributed to the annual value of -67.37% for FY2024, which is 2246.00% down from last year.
  • Latest data reveals that Ionis Pharmaceuticals reported Operating Margin of -102.21% as of Q3 2025, which was down 303.23% from 50.29% recorded in Q2 2025.
  • In the past 5 years, Ionis Pharmaceuticals' Operating Margin registered a high of 50.29% during Q2 2025, and its lowest value of -136.95% during Q4 2022.
  • Its 3-year average for Operating Margin is -64.96%, with a median of -87.45% in 2023.
  • Its Operating Margin has fluctuated over the past 5 years, first soared by 34,008bps in 2021, then crashed by 18,709bps in 2022.
  • Ionis Pharmaceuticals' Operating Margin (Quarterly) stood at 50.14% in 2021, then tumbled by 18,709bps to -136.95% in 2022, then soared by 13,507bps to -1.89% in 2023, then crashed by 4,702bps to -48.91% in 2024, then skyrocketed by 888bps to -102.21% in 2025.
  • Its last three reported values are -102.21% in Q3 2025, 50.29% for Q2 2025, and -111.59% during Q1 2025.