Ionis Pharmaceuticals (IONS) Operating Margin (2009 - 2026)
Ionis Pharmaceuticals (IONS) posted quarterly Operating Margin of 38.18% for Q2 2026, down 6911.0% year-over-year from 0.56% in Q2 2025, and up 83.74% quarter-over-quarter from 234.85% in Q1 2026.
Ionis Pharmaceuticals (IONS) Operating Margin (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' Operating Margin history runs 18 years deep, the most recent figure standing at 38.18% for Q2 2026.
- In Q2 2026, Operating Margin fell 6911.0% year-over-year to 38.18%; the TTM figure through Jun 2026 stood at 87.66% (down 5943.0% YoY), while the FY2025 annual figure was 40.45%, up 2693.0% from the prior year.
- Operating Margin for Q2 2026 stood at 38.18%, up from 234.85% in the prior quarter.
- The five-year high for Operating Margin was 30.93% in Q2 2025, with the low at 234.85% in Q1 2026.
- The 5-year median for Operating Margin is 75.68% (2023), against an average of 77.27%.
- The sharpest annual moves came in 2022 and 2023: Operating Margin tumbled 18709 bps in 2022, then jumped 13507 bps in 2023.
- Ionis Pharmaceuticals' Operating Margin stood at 136.95% in 2022, then surged by 99 bps to 1.89% in 2023, then plunged by 2493 bps to 48.91% in 2024, then sank by 116 bps to 105.47% in 2025, then surged by 64 bps to 38.18% in 2026.
- Business Quant data shows IONS's Operating Margin at 38.18% in Q2 2026, 234.85% in Q1 2026, and 105.47% in Q4 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 31.68% |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | - |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 19.06% |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | -105.20% |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 19.75% |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 17.93% |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | -0.36% |
| 10 | Ionis Pharmaceuticals | 9.48 Bn | 7.43 Bn | 265.21 Mn | -38.18% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -38.18% |
| Mar 31, 2026 | -234.85% |
| Dec 31, 2025 | -105.47% |
| Sep 30, 2025 | -102.21% |
| Jun 30, 2025 | 30.93% |
| Mar 31, 2025 | -111.59% |
| Dec 31, 2024 | -48.91% |
| Sep 30, 2024 | -111.09% |
| Jun 30, 2024 | -29.34% |
| Mar 31, 2024 | -125.12% |
| Dec 31, 2023 | -1.89% |
| Sep 30, 2023 | -99.35% |
| Jun 30, 2023 | -47.87% |
| Mar 31, 2023 | -87.45% |
| Dec 31, 2022 | -136.95% |
| Sep 30, 2022 | -37.03% |
| Jun 30, 2022 | -63.92% |
| Mar 31, 2022 | -40.52% |
| Dec 31, 2021 | 50.14% |
| Sep 30, 2021 | -64.50% |