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Asset Utilization RatioAssets AverageDebt RatioDebt to EquityEBIT MarginEBITDA MarginEBT MarginEnterprise ValueEquity AverageEquity RatioFCF MarginGross MarginInterest Coverage RatioInventory AverageInvested CapitalNet MarginOperating MarginReturn on AssetsReturn on Capital EmployedReturn on EquityReturn on Invested CapitalReturn on SalesTimes Interest Earned

Ionis Pharmaceuticals (IONS) Operating Margin (2016 - 2025)

Ionis Pharmaceuticals (IONS) has 17 years of Operating Margin data on record, last reported at 4442.9% in Q4 2025.

  • For Q4 2025, Operating Margin rose 449182.0% year-over-year to 4442.9%; the TTM value through Dec 2025 reached 67.98%, up 3102.0%, while the annual FY2025 figure was 2211.12%, 227850.0% up from the prior year.
  • Operating Margin reached 4442.9% in Q4 2025 per IONS's latest filing, up from 102.21% in the prior quarter.
  • Across five years, Operating Margin topped out at 4442.9% in Q4 2025 and bottomed at 220303.33% in Q2 2024.
  • Average Operating Margin over 5 years is 10932.78%, with a median of 73.16% recorded in 2021.
  • Peak YoY movement for Operating Margin: tumbled -22025546bps in 2024, then surged 22035363bps in 2025.
  • A 5-year view of Operating Margin shows it stood at 367.67% in 2021, then tumbled by -137bps to 136.95% in 2022, then surged by 162bps to 85.51% in 2023, then tumbled by -157bps to 48.91% in 2024, then skyrocketed by 9184bps to 4442.9% in 2025.
  • Per Business Quant database, its latest 3 readings for Operating Margin were 4442.9% in Q4 2025, 102.21% in Q3 2025, and 50.29% in Q2 2025.