Ionis Pharmaceuticals (IONS) Return on Sales (2009 - 2026)

Ionis Pharmaceuticals (IONS) recorded quarterly Return on Sales of 0.0% in Q1 2026, up 66.9% quarter-over-quarter from 0.01% in Q4 2025, and up 1.0% on a YoY basis from 0.0% in Q1 2025.

Ionis Pharmaceuticals (IONS) Return on Sales (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' Return on Sales history runs 18 years deep, the most recent figure standing at 0.0% for Q1 2026.

  • In Q1 2026, Return on Sales rose 1.0% year-over-year to 0.0%; the TTM figure through Mar 2026 stood at 0.01% (changed 0.0% YoY), while the FY2025 annual figure was 0.0%, changed 0.0% from the prior year.
  • Return on Sales was 0.0% for Q1 2026 at Ionis Pharmaceuticals, up from 0.01% in the prior quarter.
  • In the past five years, Return on Sales ranged from a high of 0.62% in Q2 2025 to a low of 0.01% in Q1 2024.
  • Historically, Return on Sales has averaged 0.03% across 5 years, with a median of 0.0% in 2024.
  • The sharpest annual moves came in 2022 and 2025: Return on Sales slipped 1 bps in 2022, then jumped 62 bps in 2025.
  • A 5-year view of Return on Sales shows it stood at 0.0% in 2022, then soared by 92 bps to 0.0% in 2023, then slumped by 1524 bps to 0.0% in 2024, then slumped by 145 bps to 0.01% in 2025, then surged by 67 bps to 0.0% in 2026.
  • The last three Return on Sales figures came in at 0.0% (Q1 2026), 0.01% (Q4 2025), and 0.01% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROS (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 0.00%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - 0.00%
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 0.00%
9 Abivax 91.96 Bn 91.96 Bn - -
10 Ionis Pharmaceuticals 12.23 Bn 10.31 Bn 243.11 Mn 0.00%

Historic Data

Download Data
DateValue
Mar 31, 2026 0.00%
Dec 31, 2025 -0.01%
Sep 30, 2025 -0.01%
Jun 30, 2025 0.62%
Mar 31, 2025 -0.01%
Dec 31, 2024 0.00%
Sep 30, 2024 -0.01%
Jun 30, 2024 0.00%
Mar 31, 2024 -0.01%
Dec 31, 2023 0.00%
Sep 30, 2023 -0.01%
Jun 30, 2023 0.00%
Mar 31, 2023 -0.01%
Dec 31, 2022 0.00%
Sep 30, 2022 0.00%
Jun 30, 2022 -0.01%
Mar 31, 2022 0.00%
Dec 31, 2021 0.01%
Sep 30, 2021 -0.01%
Jun 30, 2021 -0.01%