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Ionis Pharmaceuticals (IONS) Return on Invested Capital (2016 - 2025)

Ionis Pharmaceuticals has reported Return on Invested Capital over the past 15 years, most recently at 0.05% for Q4 2025.

  • Quarterly results put Return on Invested Capital at 0.05% for Q4 2025, up 77.0% from a year ago — trailing twelve months through Dec 2025 was 0.05% (up 77.0% YoY), and the annual figure for FY2025 was 0.07%, up 99.0%.
  • Return on Invested Capital for Q4 2025 was 0.05% at Ionis Pharmaceuticals, up from 0.22% in the prior quarter.
  • Over the last five years, Return on Invested Capital for IONS hit a ceiling of 0.05% in Q4 2025 and a floor of 1.63% in Q3 2023.
  • Median Return on Invested Capital over the past 5 years was 0.6% (2021), compared with a mean of 0.58%.
  • Biggest five-year swings in Return on Invested Capital: plummeted -165bps in 2023 and later surged 89bps in 2024.
  • Ionis Pharmaceuticals' Return on Invested Capital stood at 0.05% in 2021, then tumbled by -1518bps to 0.73% in 2022, then tumbled by -42bps to 1.04% in 2023, then skyrocketed by 30bps to 0.72% in 2024, then skyrocketed by 106bps to 0.05% in 2025.
  • The last three reported values for Return on Invested Capital were 0.05% (Q4 2025), 0.22% (Q3 2025), and 0.3% (Q2 2025) per Business Quant data.