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Asset Utilization RatioAssets AverageDebt RatioDebt to EquityEBIT MarginEBITDA MarginEBT MarginEnterprise ValueEquity AverageEquity RatioFCF MarginGross MarginInterest Coverage RatioInventory AverageInvested CapitalNet MarginOperating MarginReturn on AssetsReturn on Capital EmployedReturn on EquityReturn on Invested CapitalReturn on SalesTimes Interest Earned

Ionis Pharmaceuticals (IONS) Return on Equity (2016 - 2025)

Ionis Pharmaceuticals has reported Return on Equity over the past 16 years, most recently at 0.0% for Q4 2025.

  • Quarterly results put Return on Equity at 0.0% for Q4 2025, up 73.0% from a year ago — trailing twelve months through Dec 2025 was 0.0% (up 73.0% YoY), and the annual figure for FY2025 was 0.0%, up 93.0%.
  • Return on Equity for Q4 2025 was 0.0% at Ionis Pharmaceuticals, up from 0.41% in the prior quarter.
  • Over the last five years, Return on Equity for IONS hit a ceiling of 0.01% in Q3 2022 and a floor of 1.31% in Q2 2024.
  • Median Return on Equity over the past 5 years was 0.49% (2021), compared with a mean of 0.54%.
  • Biggest five-year swings in Return on Equity: crashed -111bps in 2023 and later soared 82bps in 2025.
  • Ionis Pharmaceuticals' Return on Equity stood at 0.04% in 2021, then tumbled by -953bps to 0.46% in 2022, then plummeted by -126bps to 1.04% in 2023, then skyrocketed by 30bps to 0.73% in 2024, then soared by 100bps to 0.0% in 2025.
  • The last three reported values for Return on Equity were 0.0% (Q4 2025), 0.41% (Q3 2025), and 0.49% (Q2 2025) per Business Quant data.