A total of 10 institutions have reported a stake in Ionis Pharmaceuticals Inc (NASDAQ:IONS) as of December 2025, according to recent 13F filings with the SEC.
| Owner Name | Date | Shares Held | Change (QoQ) | Change (%) | Value (USD) |
|---|---|---|---|---|---|
| FMR LLC | 30 Sep, 2025 | 23,689,038 | 46,048 | 0.19% | $1,549,736,866.00 |
| VANGUARD GROUP INC | 30 Sep, 2025 | 16,481,730 | -233,116 | -1.39% | $1,078,234,776.00 |
| T. Rowe Price Investment Management, Inc. | 30 Sep, 2025 | 13,156,929 | -2,891,792 | -18.02% | $860,727.00 |
| Capital World Investors | 30 Sep, 2025 | 12,722,728 | 182,540 | 1.46% | $832,320,866.00 |
| BlackRock, Inc. | 30 Sep, 2025 | 10,447,940 | -448,997 | -4.12% | $683,504,235.00 |
| WELLINGTON MANAGEMENT GROUP LLP | 30 Sep, 2025 | 6,588,811 | 243,035 | 3.83% | $431,040,015.00 |
| Lombard Odier Asset Management (Europe) Ltd | 30 Sep, 2025 | 6,494,000 | 6,494,000 | 0.00% | $8,957,694.00 |
| Bellevue Group AG | 30 Sep, 2025 | 6,244,451 | -1,608,747 | -20.49% | $408,511,984.00 |
| STATE STREET CORP | 30 Sep, 2025 | 4,388,651 | -141,747 | -3.13% | $287,105,548.00 |
| Deep Track Capital, LP | 30 Sep, 2025 | 3,808,144 | -1,083,400 | -22.15% | $249,128,780.00 |
| GEODE CAPITAL MANAGEMENT, LLC | 30 Sep, 2025 | 3,066,289 | 175,194 | 6.06% | $200,632,333.00 |
| Tweedy, Browne Co LLC | 30 Sep, 2025 | 2,901,216 | 9,268 | 0.32% | $189,797,551.00 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 30 Sep, 2025 | 2,729,685 | -396,388 | -12.68% | $178,577.00 |
| CITADEL ADVISORS LLC | 30 Sep, 2025 | 2,402,065 | 2,402,065 | 0.00% | $157,143,093.00 |
| TWO SIGMA ADVISERS, LP | 30 Sep, 2025 | 2,073,111 | -594,500 | -22.29% | $135,622,922.00 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 30 Sep, 2025 | 1,979,669 | 1,979,669 | 0.00% | $129,509,946.00 |
| TWO SIGMA INVESTMENTS, LP | 30 Sep, 2025 | 1,575,943 | -212,424 | -11.88% | $103,098,191.00 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30 Sep, 2025 | 1,519,951 | 32,133 | 2.16% | $99,435,194.00 |
| Pictet Asset Management Holding SA | 30 Sep, 2025 | 1,393,124 | 784,484 | 128.89% | $90,476,958.00 |
| AMERICAN CENTURY COMPANIES INC | 30 Sep, 2025 | 1,372,225 | 899,476 | 190.27% | $89,771,090.00 |