Ionis Pharmaceuticals (IONS) Return on Capital Employed (2010 - 2026)
Ionis Pharmaceuticals (IONS) recorded quarterly Return on Capital Employed of 12.72% in Q1 2026, up 16.82% quarter-over-quarter from 15.29% in Q4 2025, and up 506.0% on a YoY basis from 2.1% in Q1 2025.
Ionis Pharmaceuticals (IONS) Return on Capital Employed (2010 - 2026) Analysis & Trends
Ionis Pharmaceuticals' Return on Capital Employed history runs 17 years deep, the most recent figure standing at 12.72% for Q1 2026.
- In Q1 2026, Return on Capital Employed rose 506.0% year-over-year to 12.72%; the TTM figure through Mar 2026 stood at 12.72% (up 506.0% YoY), while the FY2025 annual figure was 3.21%, up 38.0% from the prior year.
- Return on Capital Employed was 12.72% for Q1 2026 at Ionis Pharmaceuticals, up from 15.29% in the prior quarter.
- In the past five years, Return on Capital Employed ranged from a high of 0.86% in Q3 2022 to a low of 21.8% in Q3 2023.
- Historically, Return on Capital Employed has averaged 13.26% across 5 years, with a median of 15.07% in 2024.
- The sharpest annual moves came in 2022 and 2023: Return on Capital Employed soared 1342 bps in 2022, then slumped 2266 bps in 2023.
- A 5-year view of Return on Capital Employed shows it stood at 18.93% in 2022, then climbed by 26 bps to 14.07% in 2023, then declined by 24 bps to 17.38% in 2024, then gained by 12 bps to 15.29% in 2025, then climbed by 17 bps to 12.72% in 2026.
- The last three Return on Capital Employed figures came in at 12.72% (Q1 2026), 15.29% (Q4 2025), and 13.2% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | 450.31% |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | 51.73% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -107.40% |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 21.10% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -50.43% |
| 10 | Ionis Pharmaceuticals | 12.23 Bn | 10.31 Bn | 243.11 Mn | -12.72% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -12.72% |
| Dec 31, 2025 | -15.29% |
| Sep 30, 2025 | -13.20% |
| Jun 30, 2025 | -13.31% |
| Mar 31, 2025 | -17.77% |
| Dec 31, 2024 | -17.38% |
| Sep 30, 2024 | -14.35% |
| Jun 30, 2024 | -15.07% |
| Mar 31, 2024 | -15.26% |
| Dec 31, 2023 | -14.07% |
| Sep 30, 2023 | -21.80% |
| Jun 30, 2023 | -17.86% |
| Mar 31, 2023 | -19.05% |
| Dec 31, 2022 | -18.93% |
| Sep 30, 2022 | 0.86% |
| Jun 30, 2022 | -0.37% |
| Mar 31, 2022 | 0.18% |
| Dec 31, 2021 | -1.33% |
| Sep 30, 2021 | -12.57% |
| Jun 30, 2021 | -10.78% |