Ionis Pharmaceuticals (IONS) Return on Capital Employed (2010 - 2026)

Ionis Pharmaceuticals' (IONS) quarterly Return on Capital Employed came in at 12.72% in Q1 2026, up 506.0% year-on-year from 2.1% in Q1 2025, and up 16.82% quarter-over-quarter from 15.29% in Q4 2025.

Ionis Pharmaceuticals (IONS) Return on Capital Employed (2010 - 2026) Analysis & Trends

Ionis Pharmaceuticals' Return on Capital Employed history runs 17 years deep, the most recent figure standing at 12.72% for Q1 2026.

  • On a quarterly basis, Return on Capital Employed rose 506.0% year-over-year to 12.72% in Q1 2026; TTM through Mar 2026 was 12.72%, a 506.0% increase from a year earlier, with the FY2025 full-year figure at 15.38%, up 230.0% from the prior year.
  • Return on Capital Employed rose to 12.72% in Q1 2026 per IONS's latest filing, from 15.29% in the prior quarter.
  • Across five years, Return on Capital Employed topped out at 0.86% in Q3 2022 and bottomed at 21.8% in Q3 2023.
  • The 5-year median for Return on Capital Employed is 15.07% (2024), against an average of 13.26%.
  • Across the five-year window, Return on Capital Employed surged 1342 bps in 2022 and slumped 2266 bps in 2023, its largest moves.
  • Year by year, Return on Capital Employed stood at 18.93% in 2022, then climbed by 26 bps to 14.07% in 2023, then declined by 24 bps to 17.38% in 2024, then gained by 12 bps to 15.29% in 2025, then climbed by 17 bps to 12.72% in 2026.
  • Per Business Quant, the three latest IONS Return on Capital Employed figures stand at 12.72% (Q1 2026), 15.29% (Q4 2025), and 13.2% (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -31.80%
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 10.46%
4 NuCana 279.75 Bn 279.75 Bn - -68.47%
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 21.10%
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 10.19%
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - -68.84%
10 Ionis Pharmaceuticals 9.21 Bn 7.29 Bn 243.11 Mn -12.72%

Historic Data

Download Data
DateValue
Mar 31, 2026 -12.72%
Dec 31, 2025 -15.29%
Sep 30, 2025 -13.20%
Jun 30, 2025 -13.31%
Mar 31, 2025 -17.77%
Dec 31, 2024 -17.38%
Sep 30, 2024 -14.35%
Jun 30, 2024 -15.07%
Mar 31, 2024 -15.26%
Dec 31, 2023 -14.07%
Sep 30, 2023 -21.80%
Jun 30, 2023 -17.86%
Mar 31, 2023 -19.05%
Dec 31, 2022 -18.93%
Sep 30, 2022 0.86%
Jun 30, 2022 -0.37%
Mar 31, 2022 0.18%
Dec 31, 2021 -1.33%
Sep 30, 2021 -12.57%
Jun 30, 2021 -10.78%