Ionis Pharmaceuticals (IONS) Return on Capital Employed (2010 - 2026)

Ionis Pharmaceuticals (IONS) recorded quarterly Return on Capital Employed of 12.72% in Q1 2026, up 16.82% quarter-over-quarter from 15.29% in Q4 2025, and up 506.0% on a YoY basis from 2.1% in Q1 2025.

Ionis Pharmaceuticals (IONS) Return on Capital Employed (2010 - 2026) Analysis & Trends

Ionis Pharmaceuticals' Return on Capital Employed history runs 17 years deep, the most recent figure standing at 12.72% for Q1 2026.

  • In Q1 2026, Return on Capital Employed rose 506.0% year-over-year to 12.72%; the TTM figure through Mar 2026 stood at 12.72% (up 506.0% YoY), while the FY2025 annual figure was 3.21%, up 38.0% from the prior year.
  • Return on Capital Employed was 12.72% for Q1 2026 at Ionis Pharmaceuticals, up from 15.29% in the prior quarter.
  • In the past five years, Return on Capital Employed ranged from a high of 0.86% in Q3 2022 to a low of 21.8% in Q3 2023.
  • Historically, Return on Capital Employed has averaged 13.26% across 5 years, with a median of 15.07% in 2024.
  • The sharpest annual moves came in 2022 and 2023: Return on Capital Employed soared 1342 bps in 2022, then slumped 2266 bps in 2023.
  • A 5-year view of Return on Capital Employed shows it stood at 18.93% in 2022, then climbed by 26 bps to 14.07% in 2023, then declined by 24 bps to 17.38% in 2024, then gained by 12 bps to 15.29% in 2025, then climbed by 17 bps to 12.72% in 2026.
  • The last three Return on Capital Employed figures came in at 12.72% (Q1 2026), 15.29% (Q4 2025), and 13.2% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 450.31%
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 51.73%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -107.40%
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 21.10%
9 Abivax 91.96 Bn 91.96 Bn - -50.43%
10 Ionis Pharmaceuticals 12.23 Bn 10.31 Bn 243.11 Mn -12.72%

Historic Data

Download Data
DateValue
Mar 31, 2026 -12.72%
Dec 31, 2025 -15.29%
Sep 30, 2025 -13.20%
Jun 30, 2025 -13.31%
Mar 31, 2025 -17.77%
Dec 31, 2024 -17.38%
Sep 30, 2024 -14.35%
Jun 30, 2024 -15.07%
Mar 31, 2024 -15.26%
Dec 31, 2023 -14.07%
Sep 30, 2023 -21.80%
Jun 30, 2023 -17.86%
Mar 31, 2023 -19.05%
Dec 31, 2022 -18.93%
Sep 30, 2022 0.86%
Jun 30, 2022 -0.37%
Mar 31, 2022 0.18%
Dec 31, 2021 -1.33%
Sep 30, 2021 -12.57%
Jun 30, 2021 -10.78%