Ionis Pharmaceuticals (IONS) Return on Capital Employed (2010 - 2026)
Ionis Pharmaceuticals' (IONS) quarterly Return on Capital Employed came in at 12.72% in Q1 2026, up 506.0% year-on-year from 2.1% in Q1 2025, and up 16.82% quarter-over-quarter from 15.29% in Q4 2025.
Ionis Pharmaceuticals (IONS) Return on Capital Employed (2010 - 2026) Analysis & Trends
Ionis Pharmaceuticals' Return on Capital Employed history runs 17 years deep, the most recent figure standing at 12.72% for Q1 2026.
- On a quarterly basis, Return on Capital Employed rose 506.0% year-over-year to 12.72% in Q1 2026; TTM through Mar 2026 was 12.72%, a 506.0% increase from a year earlier, with the FY2025 full-year figure at 15.38%, up 230.0% from the prior year.
- Return on Capital Employed rose to 12.72% in Q1 2026 per IONS's latest filing, from 15.29% in the prior quarter.
- Across five years, Return on Capital Employed topped out at 0.86% in Q3 2022 and bottomed at 21.8% in Q3 2023.
- The 5-year median for Return on Capital Employed is 15.07% (2024), against an average of 13.26%.
- Across the five-year window, Return on Capital Employed surged 1342 bps in 2022 and slumped 2266 bps in 2023, its largest moves.
- Year by year, Return on Capital Employed stood at 18.93% in 2022, then climbed by 26 bps to 14.07% in 2023, then declined by 24 bps to 17.38% in 2024, then gained by 12 bps to 15.29% in 2025, then climbed by 17 bps to 12.72% in 2026.
- Per Business Quant, the three latest IONS Return on Capital Employed figures stand at 12.72% (Q1 2026), 15.29% (Q4 2025), and 13.2% (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | -31.80% |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 10.46% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -68.47% |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 21.10% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 10.19% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | - |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | -68.84% |
| 10 | Ionis Pharmaceuticals | 9.21 Bn | 7.29 Bn | 243.11 Mn | -12.72% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -12.72% |
| Dec 31, 2025 | -15.29% |
| Sep 30, 2025 | -13.20% |
| Jun 30, 2025 | -13.31% |
| Mar 31, 2025 | -17.77% |
| Dec 31, 2024 | -17.38% |
| Sep 30, 2024 | -14.35% |
| Jun 30, 2024 | -15.07% |
| Mar 31, 2024 | -15.26% |
| Dec 31, 2023 | -14.07% |
| Sep 30, 2023 | -21.80% |
| Jun 30, 2023 | -17.86% |
| Mar 31, 2023 | -19.05% |
| Dec 31, 2022 | -18.93% |
| Sep 30, 2022 | 0.86% |
| Jun 30, 2022 | -0.37% |
| Mar 31, 2022 | 0.18% |
| Dec 31, 2021 | -1.33% |
| Sep 30, 2021 | -12.57% |
| Jun 30, 2021 | -10.78% |