As of September 29, 2026, Ionis Pharmaceuticals's top three insider holders are Brett P Monia (Chief Executive Officer, 242.76K shares), Spencer R Berthelsen (Director, 161.23K shares), Brian Birchler (Evp, Corp And Development Ops, 102.88K shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Brett P Monia | Chief Executive Officer | 242,760 | 0 | 242,760 | 19.2% | 02 Sep, 2026 |
| 2 | Spencer R Berthelsen | Director | 161,233 | 0 | 161,233 | 12.7% | 17 Jul, 2026 |
| 3 | Brian Birchler | Evp, Corp And Development Ops | 102,883 | 0 | 102,883 | 8.1% | 02 Sep, 2026 |
| 4 | Elizabeth L Hougen | Evp, Finance Cfo | 82,660 | 0 | 82,660 | 6.5% | 18 Mar, 2026 |
| 5 | Eugene Schneider | Evp, Chf Clinical Develop Ofcr | 77,114 | 0 | 77,114 | 6.1% | 30 Jun, 2026 |
| 6 | C Frank Bennett | Evp, Chief Scientific Officer | 60,128 | 0 | 60,128 | 4.8% | 02 Sep, 2026 |
| 7 | Richard S Geary | Evp, Chief Development Officer | 59,657 | 0 | 59,657 | 4.7% | 07 Nov, 2025 |
| 8 | Frederick T Muto | Director | 59,597 | 0 | 59,597 | 4.7% | 18 Jul, 2022 |
| 9 | Patrick R. O'Neil | Evp Clo General Counsel | 59,205 | 0 | 59,205 | 4.7% | 02 Sep, 2026 |
| 10 | B Lynne Parshall | Coo | 51,344 | 0 | 51,344 | 4.1% | 17 Apr, 2026 |
| 11 | Joan E Herman | Director | 51,306 | 0 | 51,306 | 4.1% | 17 Jul, 2026 |
| 12 | Joseph Loscalzo | Director | 36,330 | 0 | 36,330 | 2.9% | 06 May, 2026 |
| 13 | Joseph H Wender | Director | 0 | 36,035 | 36,035 | 2.8% | 03 Dec, 2025 |
| 14 | Onaiza Cadoret-Manier | Evp, Chf Gl Pdt Str Oper Ofc | 35,825 | 0 | 35,825 | 2.8% | 02 Feb, 2024 |
| 15 | Michael R Hayden | Director | 0 | 24,000 | 24,000 | 1.9% | 31 Jul, 2026 |
| 16 | Kyle Jenne | Evp, Chf Gl Pdt Str Ofcr | 23,713 | 0 | 23,713 | 1.9% | 17 Apr, 2026 |
| 17 | Holly B. Kordasiewicz | Evp, Chief Development Officer | 22,096 | 0 | 22,096 | 1.7% | 09 Jul, 2026 |
| 18 | Eric Swayze | Evp Research | 21,759 | 0 | 21,759 | 1.7% | 26 Jun, 2026 |
| 19 | Shannon L. Devers | Evp, Chief Human Resources Ofc | 16,348 | 0 | 16,348 | 1.3% | 02 Apr, 2026 |
| 20 | Peter N Reikes | Director | 14,222 | 0 | 14,222 | 1.1% | 19 Oct, 2021 |
| 21 | Joseph Iii Klein | Director | 11,014 | 0 | 11,014 | 0.9% | 06 Jul, 2026 |
| 22 | Michael J. Yang | Director | 7,940 | 0 | 7,940 | 0.6% | 20 Jan, 2026 |
| 23 | Joseph Baroldi | Evp, Chief Business Officer | 0 | 4,669 | 4,669 | 0.4% | 30 Jun, 2026 |
| 24 | Allene M. Diaz | Director | 3,811 | 0 | 3,811 | 0.3% | 09 Jul, 2026 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 31 Aug, 2026 | C Frank Bennett | Evp, Chief Scientific Officer | Acquired J | 110 | $51.31 | $5.64K | 60,128 | Direct |
| 31 Aug, 2026 | Brian Birchler | Evp, Corp And Development Ops | Acquired J | 58 | $51.31 | $2.98K | 102,883 | Direct |
| 31 Aug, 2026 | Brett P Monia | Chief Executive Officer | Acquired J | 98 | $51.31 | $5.03K | 242,760 | Direct |
| 31 Aug, 2026 | Patrick R. O'Neil | Evp Clo General Counsel | Acquired J | 63 | $51.31 | $3.23K | 59,205 | Direct |
| 30 Jul, 2026 | Michael R Hayden | Director | Acquired P | 15,000 | $53.38 | $800.70K | 19,000 | Indirect |
| 31 Jul, 2026 | Michael R Hayden | Director | Acquired P | 5,000 | $51.60 | $258.00K | 24,000 | Indirect |
| 15 Jul, 2026 | Peter N Reikes | Director | Acquired A | 3,399 | $0.00 | $0 | 3,399 | Direct |
| 15 Jul, 2026 | Joan E Herman | Director | Acquired M | 5,220 | $0.00 | $0 | 51,306 | Direct |
| 15 Jul, 2026 | Spencer R Berthelsen | Director | Acquired M | 5,220 | $0.00 | $0 | 161,233 | Direct |
| 15 Jul, 2026 | Ludwig Hantson | Director | Acquired A | 3,399 | $0.00 | $0 | 3,399 | Direct |
| 15 Jul, 2026 | Joan E Herman | Director | Disposed M | 5,220 | $0.00 | $0 | 2,301 | Direct |
| 15 Jul, 2026 | Spencer R Berthelsen | Director | Disposed M | 5,220 | $0.00 | $0 | 2,301 | Direct |
| 07 Jul, 2026 | Holly B. Kordasiewicz | Evp, Chief Development Officer | Disposed S | 362 | $84.30 | $30.52K | 22,096 | Direct |
| 07 Jul, 2026 | Allene M. Diaz | Director | Acquired M | 10,111 | $47.11 | $476.33K | 13,922 | Direct |
| 07 Jul, 2026 | C Frank Bennett | Evp, Chief Scientific Officer | Disposed S | 5,536 | $83.58 | $462.69K | 75,018 | Direct |
| 07 Jul, 2026 | C Frank Bennett | Evp, Chief Scientific Officer | Acquired J | 15,000 | $0.00 | $0 | 15,000 | Indirect |
| 07 Jul, 2026 | Allene M. Diaz | Director | Disposed S | 10,111 | $85.42 | $863.64K | 3,811 | Direct |
| 07 Jul, 2026 | C Frank Bennett | Evp, Chief Scientific Officer | Disposed S | 15,000 | $85.46 | $1.28Mn | 0 | Indirect |
| 07 Jul, 2026 | Allene M. Diaz | Director | Disposed M | 10,111 | $0.00 | $0 | 0 | Direct |
| 07 Jul, 2026 | C Frank Bennett | Evp, Chief Scientific Officer | Disposed J | 15,000 | $0.00 | $0 | 12,109 | Direct |