Upstream Bio reported a gross margin of -425.87% and a net margin of -5,137.00% for the quarter ended Jun 2026. These financial ratios cover 12 quarters of results from Sep 2023 through Jun 2026, standardized by Business Quant from the company’s SEC filings.
| Ratios | Sep2023 | Dec2023 | Mar2024 | Jun2024 | Sep2024 | Dec2024 | Mar2025 | Jun2025 | Sep2025 | Dec2025 | Mar2026 | Jun2026 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Profitability | ||||||||||||
| Gross Margin | 45.16% | -177.65% | -258.98% | -350.24% | -276.15% | -967.24% | -272.18% | -1,148.80% | -380.95% | -425.87% | ||
| EBT Margin | -1,265.54% | -2,846.89% | -2,352.34% | -3,445.88% | -2,634.10% | -3,465.25% | -5,586.57% | -4,259.98% | -4,938.36% | -6,364.22% | -4,259.67% | -5,137.00% |
| EBIT Margin | -1,511.43% | -3,184.44% | -2,345.78% | -3,439.22% | -3,112.52% | -4,293.31% | -5,656.01% | -4,732.87% | -5,539.39% | -6,911.23% | -4,218.09% | -5,480.98% |
| EBITDA Margin | -1,511.43% | -3,184.44% | -2,345.78% | -3,439.22% | -3,112.52% | -4,293.31% | -5,656.01% | -4,732.87% | -5,539.39% | -6,911.23% | -4,218.09% | -5,480.98% |
| Operating Margin | -1,511.43% | -3,184.44% | -2,345.78% | -3,439.22% | -3,112.52% | -4,293.31% | -5,656.01% | -4,732.87% | -5,539.39% | -6,911.23% | -4,218.09% | -5,480.98% |
| Net Margin | -1,006.92% | -3,329.78% | -2,189.06% | -3,835.69% | -3,465.07% | -3,554.65% | -4,818.02% | -4,265.31% | -4,941.14% | -6,356.14% | -4,259.67% | -5,137.00% |
| FCF Margin | -3,580.00% | -2,744.06% | -1,575.69% | -2,300.16% | -3,229.53% | -7,272.97% | -4,187.73% | -3,265.59% | -4,593.56% | -4,627.85% | -4,608.15% | |
| Efficiency | ||||||||||||
| Assets AverageAssets Avg. | 357.21M | 468.94M | 438.35M | 405.86M | 372.48M | 335.91M | 299.61M | |||||
| Asset Utilization RatioAsset Util. | 0.01 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | |||||
| Valuation | ||||||||||||
| Price to EarningsP/E | -10.32 | -12.04 | -14.78 | -30.10 | -34.68 | -11.12 | -9.54 | |||||
| Price to SalesP/S | 366.95 | 580.00 | 630.42 | 0.00M | 0.00M | 473.67 | 490.32 | |||||
| Price to BookP/B | 0.48 | 0.74 | 1.45 | 2.68 | 4.33 | 1.61 | 1.40 | |||||
| Enterprise Value | -245.51M | -103.10M | 197.12M | 643.30M | 1,131.05M | 195.20M | 117.71M | |||||
| EV to EBIT | 9.33 | 3.22 | -4.45 | -17.00 | -24.50 | -4.48 | -2.78 | |||||
| EV to EBITDA | 9.33 | 3.22 | -4.45 | -17.00 | -24.50 | -4.48 | -2.78 | |||||
| Market Capitalization | 224.94M | 328.28M | 590.70M | 1,015.73M | 1,472.55M | 489.78M | 379.02M | |||||
| Price to FCFP/FCF | -11.36 | -7.97 | -15.05 | -45.54 | -47.99 | -10.24 | -10.64 | |||||
| EV to FCF | 12.40 | 2.50 | -5.02 | -28.84 | -36.86 | -4.08 | -3.30 | |||||
| EV to CFO | 12.52 | 2.50 | -5.02 | -28.93 | -36.92 | -4.08 | -3.30 | |||||
| Return Ratios | ||||||||||||
| Return on Sales [ROS]ROS | -1,511.43% | -3,184.44% | -2,345.78% | -3,439.22% | -3,112.52% | -4,293.31% | -5,656.01% | -4,732.87% | -5,539.39% | -6,911.23% | -4,218.09% | -5,480.98% |
| Return on Capital Employed [ROCE]ROCE | -22.44% | -20.63% | -28.44% | -35.67% | -44.66% | -53.36% | -58.69% | |||||
| Return on Assets [ROA]ROA | -19.56% | -18.43% | -24.81% | -31.17% | -39.67% | -47.69% | -53.40% |