Upstream Bio (UPB) Operating Margin (2023 - 2026)
Upstream Bio (UPB) posted quarterly Operating Margin of 4218.09% for Q1 2026, up 143792.0% year-over-year from N/an in Q1 2025, and up 38.97% quarter-over-quarter from 6911.23% in Q4 2025.
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Upstream Bio (UPB) Operating Margin (2023 - 2026) Analysis & Trends
Upstream Bio's Operating Margin history runs 4 years deep, the most recent figure standing at 4218.09% for Q1 2026.
- In Q1 2026, Operating Margin rose 143792.0% year-over-year to 4218.09%; the TTM figure through Mar 2026 stood at 5176.49% (down 104914.0% YoY), while the FY2025 annual figure was 5618.82%, down 233763.0% from the prior year.
- Operating Margin for Q1 2026 stood at 4218.09%, up from 6911.23% in the prior quarter.
- The five-year high for Operating Margin was 1511.43% in Q3 2023, with the low at 6911.23% in Q4 2025.
- The 4-year median for Operating Margin is 4218.09% (2026), against an average of 4085.84%.
- The sharpest annual moves came in 2025 and 2026: Operating Margin tumbled 331023 bps in 2025, then surged 143792 bps in 2026.
- Upstream Bio's Operating Margin stood at 3184.44% in 2023, then slumped by 35 bps to 4293.31% in 2024, then slumped by 61 bps to 6911.23% in 2025, then surged by 39 bps to 4218.09% in 2026.
- Business Quant data shows UPB's Operating Margin at 4218.09% in Q1 2026, 6911.23% in Q4 2025, and 5539.39% in Q3 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | 32.54% |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -562.07% |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | - |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 19.06% |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | 17.93% |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 19.75% |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -0.36% |
| 10 | Upstream Bio | 327.95 Mn | 327.95 Mn | -3.29 Mn | -5,480.98% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -5,480.98% |
| Mar 31, 2026 | -4,218.09% |
| Dec 31, 2025 | -6,911.23% |
| Sep 30, 2025 | -5,539.39% |
| Jun 30, 2025 | -4,732.87% |
| Mar 31, 2025 | -5,656.01% |
| Dec 31, 2024 | -4,293.31% |
| Sep 30, 2024 | -3,112.52% |
| Jun 30, 2024 | -3,439.22% |
| Mar 31, 2024 | -2,345.78% |
| Dec 31, 2023 | -3,184.44% |
| Sep 30, 2023 | -1,511.43% |