Upstream Bio UPB
NASDAQ UPB
$6.01 -0.07 (-1.15%)
As of: Sep 4, 2026 · 3:59 PM EDT

Upstream Bio (UPB) FCF Margin (2023 - 2026)

Upstream Bio (UPB) posted quarterly FCF Margin of 4627.85% for Q1 2026, up 264512.0% year-over-year from N/an in Q1 2025, and down 0.56% quarter-over-quarter from 4601.95% in Q4 2025.

Analysis

Upstream Bio (UPB) FCF Margin (2023 - 2026) Analysis & Trends

Upstream Bio's FCF Margin history runs 4 years deep, the most recent figure standing at 4627.85% for Q1 2026.

  • In Q1 2026, FCF Margin rose 264512.0% year-over-year to 4627.85%; the TTM figure through Mar 2026 stood at 4216.74% (down 59509.0% YoY), while the FY2025 annual figure was 4675.54%, down 215727.0% from the prior year.
  • FCF Margin for Q1 2026 stood at 4627.85%, down from 4601.95% in the prior quarter.
  • The five-year high for FCF Margin was 1575.69% in Q2 2024, with the low at 7272.97% in Q1 2025.
  • The 4-year median for FCF Margin is 3420.51% (2023), against an average of 3740.88%.
  • The sharpest annual moves came in 2025 and 2026: FCF Margin sank 452891 bps in 2025, then soared 264512 bps in 2026.
  • Upstream Bio's FCF Margin stood at 3580.0% in 2023, then increased by 9 bps to 3261.01% in 2024, then slumped by 41 bps to 4601.95% in 2025, then dropped by 1 bps to 4627.85% in 2026.
  • Business Quant data shows UPB's FCF Margin at 4627.85% in Q1 2026, 4601.95% in Q4 2025, and 3257.39% in Q3 2025.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) FCF Margin (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 30.39%
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn 13.35%
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn -
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn -388.28%
5 Revolution Medicines 44.33 Bn 44.33 Bn - -
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 25.68%
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn 22.62%
8 Royalty Pharma 28.45 Bn 27.61 Bn - 70.82%
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn -22.35%
10 Upstream Bio 327.95 Mn 327.95 Mn -3.29 Mn -4,608.15%
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -4,608.15%
Mar 31, 2026 -4,627.85%
Dec 31, 2025 -4,593.56%
Sep 30, 2025 -3,265.59%
Jun 30, 2025 -4,187.73%
Mar 31, 2025 -7,272.97%
Dec 31, 2024 -3,229.53%
Sep 30, 2024 -2,300.16%
Jun 30, 2024 -1,575.69%
Mar 31, 2024 -2,744.06%
Dec 31, 2023 -3,580.00%