Upstream Bio (UPB) FCF Margin (2023 - 2026)
Upstream Bio (UPB) recorded quarterly FCF Margin of 4627.85% in Q1 2026, down 0.56% quarter-over-quarter from 4601.95% in Q4 2025, and up 264512.0% on a YoY basis from N/an in Q1 2025.
Upstream Bio (UPB) FCF Margin (2023 - 2026) Analysis & Trends
Upstream Bio's FCF Margin history runs 4 years deep, the most recent figure standing at 4627.85% for Q1 2026.
- In Q1 2026, FCF Margin rose 264512.0% year-over-year to 4627.85%; the TTM figure through Mar 2026 stood at 4216.74% (down 59509.0% YoY), while the FY2025 annual figure was 4675.54%, down 215727.0% from the prior year.
- FCF Margin was 4627.85% for Q1 2026 at Upstream Bio, down from 4601.95% in the prior quarter.
- In the past five years, FCF Margin ranged from a high of 1575.69% in Q2 2024 to a low of 7272.97% in Q1 2025.
- Historically, FCF Margin has averaged 3740.88% across 4 years, with a median of 3420.51% in 2023.
- The sharpest annual moves came in 2025 and 2026: FCF Margin slumped 452891 bps in 2025, then jumped 264512 bps in 2026.
- A 4-year view of FCF Margin shows it stood at 3580.0% in 2023, then rose by 9 bps to 3261.01% in 2024, then tumbled by 41 bps to 4601.95% in 2025, then declined by 1 bps to 4627.85% in 2026.
- The last three FCF Margin figures came in at 4627.85% (Q1 2026), 4601.95% (Q4 2025), and 3257.39% (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -3.98% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 43.35% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Upstream Bio | 339.03 Mn | 339.03 Mn | -3.94 Mn | -4,627.85% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -4,627.85% |
| Dec 31, 2025 | -4,601.95% |
| Sep 30, 2025 | -3,257.39% |
| Jun 30, 2025 | -4,187.73% |
| Mar 31, 2025 | -7,272.97% |
| Dec 31, 2024 | -3,261.01% |
| Sep 30, 2024 | -2,300.16% |
| Jun 30, 2024 | -1,575.69% |
| Mar 31, 2024 | -2,744.06% |
| Dec 31, 2023 | -3,580.00% |