Upstream Bio (UPB) FCF Margin (2023 - 2026)
Upstream Bio's (UPB) quarterly FCF Margin came in at 4627.85% in Q1 2026, up 264512.0% year-on-year from N/an in Q1 2025, and down 0.56% quarter-over-quarter from 4601.95% in Q4 2025.
Upstream Bio (UPB) FCF Margin (2023 - 2026) Analysis & Trends
Upstream Bio's FCF Margin history runs 4 years deep, the most recent figure standing at 4627.85% for Q1 2026.
- On a quarterly basis, FCF Margin rose 264512.0% year-over-year to 4627.85% in Q1 2026; TTM through Mar 2026 was 4216.74%, a 59509.0% decrease from a year earlier, with the FY2025 full-year figure at 4675.54%, down 215727.0% from the prior year.
- FCF Margin fell to 4627.85% in Q1 2026 per UPB's latest filing, from 4601.95% in the prior quarter.
- Across five years, FCF Margin topped out at 1575.69% in Q2 2024 and bottomed at 7272.97% in Q1 2025.
- The 4-year median for FCF Margin is 3420.51% (2023), against an average of 3740.88%.
- Across the five-year window, FCF Margin slumped 452891 bps in 2025 and soared 264512 bps in 2026, its largest moves.
- Year by year, FCF Margin stood at 3580.0% in 2023, then rose by 9 bps to 3261.01% in 2024, then sank by 41 bps to 4601.95% in 2025, then declined by 1 bps to 4627.85% in 2026.
- Per Business Quant, the three latest UPB FCF Margin figures stand at 4627.85% (Q1 2026), 4601.95% (Q4 2025), and 3257.39% (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 10.45% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 43.35% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 23.53% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | - |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Upstream Bio | 347.73 Mn | 347.73 Mn | -3.94 Mn | -4,627.85% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -4,627.85% |
| Dec 31, 2025 | -4,601.95% |
| Sep 30, 2025 | -3,257.39% |
| Jun 30, 2025 | -4,187.73% |
| Mar 31, 2025 | -7,272.97% |
| Dec 31, 2024 | -3,261.01% |
| Sep 30, 2024 | -2,300.16% |
| Jun 30, 2024 | -1,575.69% |
| Mar 31, 2024 | -2,744.06% |
| Dec 31, 2023 | -3,580.00% |