Upstream Bio (UPB) FCF Margin (2023 - 2026)
Upstream Bio (UPB) posted quarterly FCF Margin of 4627.85% for Q1 2026, up 264512.0% year-over-year from N/an in Q1 2025, and down 0.56% quarter-over-quarter from 4601.95% in Q4 2025.
Analysis
Upstream Bio (UPB) FCF Margin (2023 - 2026) Analysis & Trends
Upstream Bio's FCF Margin history runs 4 years deep, the most recent figure standing at 4627.85% for Q1 2026.
- In Q1 2026, FCF Margin rose 264512.0% year-over-year to 4627.85%; the TTM figure through Mar 2026 stood at 4216.74% (down 59509.0% YoY), while the FY2025 annual figure was 4675.54%, down 215727.0% from the prior year.
- FCF Margin for Q1 2026 stood at 4627.85%, down from 4601.95% in the prior quarter.
- The five-year high for FCF Margin was 1575.69% in Q2 2024, with the low at 7272.97% in Q1 2025.
- The 4-year median for FCF Margin is 3420.51% (2023), against an average of 3740.88%.
- The sharpest annual moves came in 2025 and 2026: FCF Margin sank 452891 bps in 2025, then soared 264512 bps in 2026.
- Upstream Bio's FCF Margin stood at 3580.0% in 2023, then increased by 9 bps to 3261.01% in 2024, then slumped by 41 bps to 4601.95% in 2025, then dropped by 1 bps to 4627.85% in 2026.
- Business Quant data shows UPB's FCF Margin at 4627.85% in Q1 2026, 4601.95% in Q4 2025, and 3257.39% in Q3 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 30.39% |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 13.35% |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | - |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -388.28% |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | - |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 25.68% |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | 22.62% |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 70.82% |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -22.35% |
| 10 | Upstream Bio | 327.95 Mn | 327.95 Mn | -3.29 Mn | -4,608.15% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -4,608.15% |
| Mar 31, 2026 | -4,627.85% |
| Dec 31, 2025 | -4,593.56% |
| Sep 30, 2025 | -3,265.59% |
| Jun 30, 2025 | -4,187.73% |
| Mar 31, 2025 | -7,272.97% |
| Dec 31, 2024 | -3,229.53% |
| Sep 30, 2024 | -2,300.16% |
| Jun 30, 2024 | -1,575.69% |
| Mar 31, 2024 | -2,744.06% |
| Dec 31, 2023 | -3,580.00% |