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Asset Utilization RatioAssets AverageEBIT MarginEBITDA MarginEBT MarginEnterprise ValueEquity AverageEquity RatioFCF MarginGross MarginInvested CapitalNet MarginOperating MarginReturn on AssetsReturn on Capital EmployedReturn on EquityReturn on Sales

Upstream Bio (UPB) Return on Sales (2023 - 2025)

Upstream Bio has reported Return on Sales over the past 3 years, most recently at 63.64% for Q4 2025.

  • Quarterly results put Return on Sales at 63.64% for Q4 2025, down 2899.0% from a year ago — trailing twelve months through Dec 2025 was 50.26% (down 2256.0% YoY), and the annual figure for FY2025 was 50.26%, down 2256.0%.
  • Return on Sales for Q4 2025 was 63.64% at Upstream Bio, down from 49.38% in the prior quarter.
  • Over the last five years, Return on Sales for UPB hit a ceiling of 12.66% in Q3 2023 and a floor of 63.64% in Q4 2025.
  • Median Return on Sales over the past 3 years was 31.7% (2024), compared with a mean of 35.62%.
  • Biggest five-year swings in Return on Sales: plummeted -618bps in 2024 and later crashed -2899bps in 2025.
  • Upstream Bio's Return on Sales stood at 28.47% in 2023, then dropped by -22bps to 34.65% in 2024, then tumbled by -84bps to 63.64% in 2025.
  • The last three reported values for Return on Sales were 63.64% (Q4 2025), 49.38% (Q3 2025), and 42.6% (Q2 2025) per Business Quant data.