Upstream Bio (UPB) Return on Sales (2023 - 2026)

Upstream Bio's Return on Sales history runs 4 years deep, the most recent figure standing at 0.39% for Q1 2026.

• In Q1 2026, Return on Sales rose 9.0% year-over-year to 0.39%; the TTM figure through Mar 2026 stood at 0.47% (down 13.0% YoY), while the FY2025 annual figure was 0.5%, down 23.0% from the prior year.
• Return on Sales was 0.39% for Q1 2026 at Upstream Bio, up from 0.64% in the prior quarter.
• In the past five years, Return on Sales ranged from a high of 0.13% in Q3 2023 to a low of 0.64% in Q4 2025.
• Historically, Return on Sales has averaged 0.36% across 4 years, with a median of 0.35% in 2024.
• The sharpest annual moves came in 2025 and 2026: Return on Sales fell 29 bps in 2025, then grew 9 bps in 2026.
• A 4-year view of Return on Sales shows it stood at 0.28% in 2023, then decreased by 22 bps to 0.35% in 2024, then plunged by 84 bps to 0.64% in 2025, then soared by 38 bps to 0.39% in 2026.
• The last three Return on Sales figures came in at 0.39% (Q1 2026), 0.64% (Q4 2025), and 0.49% (Q3 2025), per Business Quant data.