Upstream Bio (UPB) Equity Average (2023 - 2026)

Upstream Bio (UPB) recorded quarterly Equity Average of $321.9 million in Q1 2026, down 10.38% quarter-over-quarter from $359.2 million in Q4 2025, and down 29.68% on a YoY basis from $457.7 million in Q1 2025.

Upstream Bio (UPB) Equity Average (2023 - 2026) Analysis & Trends

Upstream Bio's Equity Average history runs 4 years deep, the most recent figure standing at $321.9 million for Q1 2026.

  • In Q1 2026, Equity Average fell 29.68% year-over-year to $321.9 million; the TTM figure through Mar 2026 stood at $321.9 million (down 29.68% YoY), while the FY2025 annual figure was $404.8 million, up 133.51% from the prior year.
  • Equity Average was $321.9 million for Q1 2026 at Upstream Bio, down from $359.2 million in the prior quarter.
  • In the past five years, Equity Average ranged from a high of $457.7 million in Q1 2025 to a low of -$153.5 million in Q3 2024.
  • Historically, Equity Average has averaged $157.5 million across 4 years, with a median of $238.3 million in 2024.
  • The sharpest annual moves came in 2025 and 2026: Equity Average soared 456.86% in 2025, then fell 29.68% in 2026.
  • A 4-year view of Equity Average shows it stood at -$117.7 million in 2023, then jumped by 231.53% to $154.8 million in 2024, then jumped by 132.07% to $359.2 million in 2025, then retreated by 10.38% to $321.9 million in 2026.
  • The last three Equity Average figures came in at $321.9 million (Q1 2026), $359.2 million (Q4 2025), and $393.7 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Equity Avg. (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 3.50 Bn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - 783.14 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 3.76 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 1.01 Bn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 21.35 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 19.01 Bn
9 Abivax 91.96 Bn 91.96 Bn - 516.41 Mn
10 Upstream Bio 339.03 Mn 339.03 Mn -3.94 Mn 321.88 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 321.88 Mn
Dec 31, 2025 359.18 Mn
Sep 30, 2025 393.66 Mn
Jun 30, 2025 427.18 Mn
Mar 31, 2025 457.73 Mn
Dec 31, 2024 154.77 Mn
Sep 30, 2024 -153.46 Mn
Jun 30, 2024 -140.01 Mn
Mar 31, 2024 -128.27 Mn
Dec 31, 2023 -117.67 Mn