Upstream Bio (UPB) Equity Average (2023 - 2026)
Upstream Bio (UPB) recorded quarterly Equity Average of $321.9 million in Q1 2026, down 10.38% quarter-over-quarter from $359.2 million in Q4 2025, and down 29.68% on a YoY basis from $457.7 million in Q1 2025.
Upstream Bio (UPB) Equity Average (2023 - 2026) Analysis & Trends
Upstream Bio's Equity Average history runs 4 years deep, the most recent figure standing at $321.9 million for Q1 2026.
- In Q1 2026, Equity Average fell 29.68% year-over-year to $321.9 million; the TTM figure through Mar 2026 stood at $321.9 million (down 29.68% YoY), while the FY2025 annual figure was $404.8 million, up 133.51% from the prior year.
- Equity Average was $321.9 million for Q1 2026 at Upstream Bio, down from $359.2 million in the prior quarter.
- In the past five years, Equity Average ranged from a high of $457.7 million in Q1 2025 to a low of -$153.5 million in Q3 2024.
- Historically, Equity Average has averaged $157.5 million across 4 years, with a median of $238.3 million in 2024.
- The sharpest annual moves came in 2025 and 2026: Equity Average soared 456.86% in 2025, then fell 29.68% in 2026.
- A 4-year view of Equity Average shows it stood at -$117.7 million in 2023, then jumped by 231.53% to $154.8 million in 2024, then jumped by 132.07% to $359.2 million in 2025, then retreated by 10.38% to $321.9 million in 2026.
- The last three Equity Average figures came in at $321.9 million (Q1 2026), $359.2 million (Q4 2025), and $393.7 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Equity Avg. (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | 3.50 Bn |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | 783.14 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | 3.76 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | 1.01 Bn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | 21.35 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 19.01 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | 516.41 Mn |
| 10 | Upstream Bio | 339.03 Mn | 339.03 Mn | -3.94 Mn | 321.88 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 321.88 Mn |
| Dec 31, 2025 | 359.18 Mn |
| Sep 30, 2025 | 393.66 Mn |
| Jun 30, 2025 | 427.18 Mn |
| Mar 31, 2025 | 457.73 Mn |
| Dec 31, 2024 | 154.77 Mn |
| Sep 30, 2024 | -153.46 Mn |
| Jun 30, 2024 | -140.01 Mn |
| Mar 31, 2024 | -128.27 Mn |
| Dec 31, 2023 | -117.67 Mn |