Upstream Bio (UPB) Net Margin (2023 - 2026)
Upstream Bio (UPB) posted quarterly Net Margin of 5975.44% for Q1 2026, down 115741.0% year-over-year from N/an in Q1 2025, and up 5.99% quarter-over-quarter from 6356.14% in Q4 2025.
Powered by 
Analysis
Upstream Bio (UPB) Net Margin (2023 - 2026) Analysis & Trends
Upstream Bio's Net Margin history runs 4 years deep, the most recent figure standing at 5975.44% for Q1 2026.
- In Q1 2026, Net Margin fell 115741.0% year-over-year to 5975.44%; the TTM figure through Mar 2026 stood at 5356.98% (down 145215.0% YoY), while the FY2025 annual figure was 5026.03%, down 180262.0% from the prior year.
- Net Margin for Q1 2026 stood at 5975.44%, up from 6356.14% in the prior quarter.
- The five-year high for Net Margin was 1006.92% in Q3 2023, with the low at 6356.14% in Q4 2025.
- The 4-year median for Net Margin is 3835.69% (2024), against an average of 3976.11%.
- The sharpest annual moves came in 2024 and 2025: Net Margin sank 22487 bps in 2024, then tumbled 280149 bps in 2025.
- Upstream Bio's Net Margin stood at 3329.78% in 2023, then retreated by 7 bps to 3554.65% in 2024, then plunged by 79 bps to 6356.14% in 2025, then increased by 6 bps to 5975.44% in 2026.
- Business Quant data shows UPB's Net Margin at 5975.44% in Q1 2026, 6356.14% in Q4 2025, and 4941.14% in Q3 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 32.99% |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 30.23% |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | 31.16% |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -539.31% |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | - |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 13.90% |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | 12.74% |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 12.09% |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -3.12% |
| 10 | Upstream Bio | 327.95 Mn | 327.95 Mn | -3.29 Mn | -5,137.00% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -5,137.00% |
| Mar 31, 2026 | -4,259.67% |
| Dec 31, 2025 | -6,356.14% |
| Sep 30, 2025 | -4,941.14% |
| Jun 30, 2025 | -4,265.31% |
| Mar 31, 2025 | -4,818.02% |
| Dec 31, 2024 | -3,554.65% |
| Sep 30, 2024 | -3,465.07% |
| Jun 30, 2024 | -3,835.69% |
| Mar 31, 2024 | -2,189.06% |
| Dec 31, 2023 | -3,329.78% |
| Sep 30, 2023 | -1,006.92% |