Upstream Bio (UPB) Net Margin (2023 - 2026)
Upstream Bio (UPB) recorded quarterly Net Margin of 3922.73% in Q1 2026, up 38.28% quarter-over-quarter from 6356.14% in Q4 2025, and up 89529.0% on a YoY basis from N/an in Q1 2025.
Upstream Bio (UPB) Net Margin (2023 - 2026) Analysis & Trends
Upstream Bio's Net Margin history runs 4 years deep, the most recent figure standing at 3922.73% for Q1 2026.
- In Q1 2026, Net Margin rose 89529.0% year-over-year to 3922.73%; the TTM figure through Mar 2026 stood at 4718.06% (down 81323.0% YoY), while the FY2025 annual figure was 5026.03%, down 180262.0% from the prior year.
- Net Margin was 3922.73% for Q1 2026 at Upstream Bio, up from 6356.14% in the prior quarter.
- In the past five years, Net Margin ranged from a high of 1006.92% in Q3 2023 to a low of 6356.14% in Q4 2025.
- Historically, Net Margin has averaged 3789.5% across 4 years, with a median of 3835.69% in 2024.
- The sharpest annual moves came in 2025 and 2026: Net Margin plunged 280149 bps in 2025, then surged 89529 bps in 2026.
- A 4-year view of Net Margin shows it stood at 3329.78% in 2023, then decreased by 7 bps to 3554.65% in 2024, then sank by 79 bps to 6356.14% in 2025, then jumped by 38 bps to 3922.73% in 2026.
- The last three Net Margin figures came in at 3922.73% (Q1 2026), 6356.14% (Q4 2025), and 4941.14% (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | 0.82% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 34.53% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Upstream Bio | 339.03 Mn | 339.03 Mn | -3.94 Mn | -3,922.73% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -3,922.73% |
| Dec 31, 2025 | -6,356.14% |
| Sep 30, 2025 | -4,941.14% |
| Jun 30, 2025 | -4,265.31% |
| Mar 31, 2025 | -4,818.02% |
| Dec 31, 2024 | -3,554.65% |
| Sep 30, 2024 | -3,465.07% |
| Jun 30, 2024 | -3,835.69% |
| Mar 31, 2024 | -2,189.06% |
| Dec 31, 2023 | -3,329.78% |
| Sep 30, 2023 | -1,006.92% |