Upstream Bio (UPB) Net Margin (2023 - 2026)
Upstream Bio's quarterly Net Margin came in at 3922.73% in Q1 2026, up 89529.0% year-on-year from N/an in Q1 2025, and up 38.28% quarter-over-quarter from 6356.14% in Q4 2025.
Upstream Bio has reported Net Margin for 4 years, with the latest figure at 3922.73% in Q1 2026.
- For the quarter ending Q1 2026, Net Margin rose 89529.0% year-over-year to 3922.73%; the trailing twelve-month figure through Mar 2026 stood at 4718.06% (down 81323.0% YoY), and the FY2025 full-year result was 5026.03%, down 180262.0% from the prior year.
- Net Margin for Q1 2026 stood at 3922.73%, up from 6356.14% in the prior quarter.
- The five-year high for Net Margin was 1006.92% in Q3 2023, with the low at 6356.14% in Q4 2025.
- Average Net Margin over 4 years is 3789.5%, with a median of 3835.69% recorded in 2024.
- Year-over-year, Net Margin plunged 280149 bps in 2025 and jumped 89529 bps in 2026.
- Tracing UPB's Net Margin over 4 years: stood at 3329.78% in 2023, then slipped by 7 bps to 3554.65% in 2024, then plunged by 79 bps to 6356.14% in 2025, then surged by 38 bps to 3922.73% in 2026.
- The last three Net Margin figures came in at 3922.73% (Q1 2026), 6356.14% (Q4 2025), and 4941.14% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - | - |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - | - |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn | 0.82% |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - | - |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn | 34.53% |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn | 20.17% |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn | 17.65% |
| 10 | Upstream Bio | 454.22 Mn | 454.22 Mn | -3.94 Mn | -3,922.73% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -3,922.73% |
| Dec 31, 2025 | -6,356.14% |
| Sep 30, 2025 | -4,941.14% |
| Jun 30, 2025 | -4,265.31% |
| Mar 31, 2025 | -4,818.02% |
| Dec 31, 2024 | -3,554.65% |
| Sep 30, 2024 | -3,465.07% |
| Jun 30, 2024 | -3,835.69% |
| Mar 31, 2024 | -2,189.06% |
| Dec 31, 2023 | -3,329.78% |
| Sep 30, 2023 | -1,006.92% |