Upstream Bio (UPB) Net Margin (2023 - 2026)
Upstream Bio's (UPB) quarterly Net Margin came in at 5975.44% in Q1 2026, down 115741.0% year-on-year from N/an in Q1 2025, and up 5.99% quarter-over-quarter from 6356.14% in Q4 2025.
Upstream Bio (UPB) Net Margin (2023 - 2026) Analysis & Trends
Upstream Bio's Net Margin history runs 4 years deep, the most recent figure standing at 5975.44% for Q1 2026.
- On a quarterly basis, Net Margin fell 115741.0% year-over-year to 5975.44% in Q1 2026; TTM through Mar 2026 was 5356.98%, a 145215.0% decrease from a year earlier, with the FY2025 full-year figure at 5026.03%, down 180262.0% from the prior year.
- Net Margin improved to 5975.44% in Q1 2026 per UPB's latest filing, from 6356.14% in the prior quarter.
- Across five years, Net Margin topped out at 1006.92% in Q3 2023 and bottomed at 6356.14% in Q4 2025.
- The 4-year median for Net Margin is 3835.69% (2024), against an average of 3976.11%.
- Across the five-year window, Net Margin slumped 22487 bps in 2024 and plunged 280149 bps in 2025, its largest moves.
- Year by year, Net Margin stood at 3329.78% in 2023, then decreased by 7 bps to 3554.65% in 2024, then tumbled by 79 bps to 6356.14% in 2025, then rose by 6 bps to 5975.44% in 2026.
- Per Business Quant, the three latest UPB Net Margin figures stand at 5975.44% (Q1 2026), 6356.14% (Q4 2025), and 4941.14% (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 15.02% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 34.53% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 20.17% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 30.33% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Upstream Bio | 347.73 Mn | 347.73 Mn | -3.94 Mn | -5,975.44% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -5,975.44% |
| Dec 31, 2025 | -6,356.14% |
| Sep 30, 2025 | -4,941.14% |
| Jun 30, 2025 | -4,265.31% |
| Mar 31, 2025 | -4,818.02% |
| Dec 31, 2024 | -3,554.65% |
| Sep 30, 2024 | -3,465.07% |
| Jun 30, 2024 | -3,835.69% |
| Mar 31, 2024 | -2,189.06% |
| Dec 31, 2023 | -3,329.78% |
| Sep 30, 2023 | -1,006.92% |