Upstream Bio (UPB) Enterprise Value (2024 - 2026)

Upstream Bio's Enterprise Value history runs 4 years deep, the most recent figure standing at -$294.6 million for Q1 2026.

• In Q1 2026, Enterprise Value rose 31.71% year-over-year to -$294.6 million; the TTM figure through Mar 2026 stood at -$294.6 million (up 31.71% YoY), while the FY2025 annual figure was -$341.5 million, up 27.41% from the prior year.
• Enterprise Value for Q1 2026 stood at -$294.6 million, up from -$341.5 million in the prior quarter.
• The five-year high for Enterprise Value was -$31.5 million in Q1 2024, with the low at -$470.5 million in Q4 2024.
• The 4-year median for Enterprise Value is -$294.6 million (2026), against an average of -$251.0 million.
• The sharpest annual moves came in 2025 and 2026: Enterprise Value sank 1269.03% in 2025, then jumped 31.71% in 2026.
• Upstream Bio's Enterprise Value stood at -$109.8 million in 2023, then tumbled by 328.42% to -$470.5 million in 2024, then advanced by 27.41% to -$341.5 million in 2025, then increased by 13.74% to -$294.6 million in 2026.
• Business Quant data shows UPB's Enterprise Value at -$294.6 million in Q1 2026, -$341.5 million in Q4 2025, and -$372.4 million in Q3 2025.