Upstream Bio (UPB) Enterprise Value (2023 - 2026)

Upstream Bio's Enterprise Value history runs 4 years deep, the most recent figure standing at -$294.6 million for Q1 2026.

• In Q1 2026, Enterprise Value rose 31.71% year-over-year to -$294.6 million; the TTM figure through Mar 2026 stood at -$294.6 million (up 31.71% YoY), while the FY2025 annual figure was -$341.5 million, up 26.65% from the prior year.
• Enterprise Value was -$294.6 million for Q1 2026 at Upstream Bio, up from -$341.5 million in the prior quarter.
• In the past five years, Enterprise Value ranged from a high of -$31.5 million in Q1 2024 to a low of -$465.6 million in Q4 2024.
• Historically, Enterprise Value has averaged -$250.5 million across 4 years, with a median of -$294.6 million in 2026.
• The sharpest annual moves came in 2025 and 2026: Enterprise Value slumped 1269.03% in 2025, then surged 31.71% in 2026.
• A 4-year view of Enterprise Value shows it stood at -$109.8 million in 2023, then plunged by 323.97% to -$465.6 million in 2024, then climbed by 26.65% to -$341.5 million in 2025, then rose by 13.74% to -$294.6 million in 2026.
• The last three Enterprise Value figures came in at -$294.6 million (Q1 2026), -$341.5 million (Q4 2025), and -$372.4 million (Q3 2025), per Business Quant data.