Upstream Bio (UPB) Enterprise Value (2023 - 2026)
Upstream Bio's quarterly Enterprise Value came in at -$294.6 million in Q1 2026, up 31.71% year-on-year from -$223.7 million in Q1 2025, and up 13.74% quarter-over-quarter from -$341.5 million in Q4 2025.
Upstream Bio has reported Enterprise Value for 4 years, with the latest figure at -$294.6 million in Q1 2026.
- For the quarter ending Q1 2026, Enterprise Value rose 31.71% year-over-year to -$294.6 million; the trailing twelve-month figure through Mar 2026 stood at -$294.6 million (up 31.71% YoY), and the FY2025 full-year result was -$341.5 million, up 26.65% from the prior year.
- Enterprise Value for Q1 2026 stood at -$294.6 million, up from -$341.5 million in the prior quarter.
- The five-year high for Enterprise Value was -$31.5 million in Q1 2024, with the low at -$465.6 million in Q4 2024.
- Average Enterprise Value over 4 years is -$250.5 million, with a median of -$294.6 million recorded in 2026.
- Year-over-year, Enterprise Value slumped 1269.03% in 2025 and jumped 31.71% in 2026.
- Tracing UPB's Enterprise Value over 4 years: stood at -$109.8 million in 2023, then tumbled by 323.97% to -$465.6 million in 2024, then grew by 26.65% to -$341.5 million in 2025, then gained by 13.74% to -$294.6 million in 2026.
- The last three Enterprise Value figures came in at -$294.6 million (Q1 2026), -$341.5 million (Q4 2025), and -$372.4 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Enterprise Value (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - | -2.32 Mn |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - | -32.30 Mn |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn | -286.70 Mn |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - | -61.46 Mn |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - | -2.77 Mn |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn | -7.25 Bn |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - | -18.44 Mn |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn | -8.75 Bn |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn | -3.01 Bn |
| 10 | Upstream Bio | 454.22 Mn | 454.22 Mn | -3.94 Mn | -294.58 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -294.58 Mn |
| Dec 31, 2025 | -341.51 Mn |
| Sep 30, 2025 | -372.43 Mn |
| Jun 30, 2025 | -393.58 Mn |
| Mar 31, 2025 | -431.38 Mn |
| Dec 31, 2024 | -465.56 Mn |
| Sep 30, 2024 | -220.66 Mn |
| Jun 30, 2024 | -47.34 Mn |
| Mar 31, 2024 | -31.51 Mn |
| Dec 31, 2023 | -109.81 Mn |
| Sep 30, 2023 | -47.32 Mn |