Upstream Bio, Inc. (UPB) Insider Ownership

Historic Insider Ownership Trends

Through the 90-day period concluding January 10, 2026, Upstream Bio's top three insider stakeholders include TenPercentOwner Upstream Llc Ai (5.49Mn shares), Director Erez Chimovits (4.55Mn shares), Director Advisors Llc Orbimed (4.55Mn shares).

Top Direct Holders

Insider ownership data is derived from the last 60 months of Form 4 SEC filings.
Holder Position Shares Report Date
Upstream Llc Ai 5,494,410 17 Oct, 2024
Advisors Llc Orbimed 4,554,873 17 Oct, 2024
Erez Chimovits 4,554,873 17 Oct, 2024
Biomedical Innovation Master Investors (Cayman) Ii L.P. Wellington 894,733 15 Oct, 2024
Everett Rand Sutherland Chief Executive Officer 75,000 06 Jan, 2026
Aaron Deykin Chief Medical Officer 33,581 06 Jan, 2026
Michael Gray Cfo And Coo 30,500 06 Jan, 2026
Adam Houghton Chief Business Officer 25,000 06 Jan, 2026
Allison Ambrose General Counsel 17,000 06 Jan, 2026

* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.

Recent Insider Transactions

Detailed insider trading activity based on Form 4 SEC filings.
Download Data
Transaction Date Insider Name Security Class Transaction Type Shares Traded Price Shares Remaining Ownership Code
02 Jan, 2026 Michael Gray Common Stock A 30,500 $0.00 30,500 D A
02 Jan, 2026 Everett Rand Sutherland Common Stock A 75,000 $0.00 75,000 D A
02 Jan, 2026 Adam Houghton Common Stock A 25,000 $0.00 25,000 D A
02 Jan, 2026 Aaron Deykin Common Stock A 32,000 $0.00 33,581 D A
02 Jan, 2026 Allison Ambrose Common Stock A 17,000 $0.00 17,000 D A
15 Oct, 2024 Advisors Llc Orbimed - - 4,554,873 I
15 Oct, 2024 Advisors Llc Orbimed Common Stock A 721,956 - 973,716 I C
15 Oct, 2024 Advisors Llc Orbimed Common Stock A 165,000 $17.00 1,138,716 I P
15 Oct, 2024 Advisors Llc Orbimed Common Stock A 2,887,833 - 3,894,873 I C
15 Oct, 2024 Advisors Llc Orbimed Common Stock A 660,000 $17.00 4,554,873 I P
15 Oct, 2024 Erez Chimovits Common Stock A 721,956 - 973,716 I C
15 Oct, 2024 Erez Chimovits Common Stock A 660,000 $17.00 4,554,873 I P
15 Oct, 2024 Erez Chimovits Common Stock A 2,887,833 - 3,894,873 I C
15 Oct, 2024 Erez Chimovits Common Stock A 165,000 $17.00 1,138,716 I P
15 Oct, 2024 Biomedical Innovation Master Investors (Cayman) Ii L.P. Wellington Common Stock A 894,733 - 894,733 D C
15 Oct, 2024 Upstream Llc Ai - - 1,175,000 D
15 Oct, 2024 Upstream Llc Ai - - 4,322,000 D
15 Oct, 2024 Upstream Llc Ai Common Stock A 1,172,410 - 5,494,410 D C
15 Oct, 2024 Upstream Llc Ai - - 5,494,410 D
15 Oct, 2024 Upstream Llc Ai Common Stock A 3,147,000 - 4,322,000 D C