As of April 17, 2026, the three largest insider holders of UPB are Upstream Llc Ai (TenPercentOwner, 5.49Mn shares), Upstream Llc Ai (TenPercentOwner, 5.49Mn shares), Erez Chimovits (Director, 4.55Mn shares).
| Holder | Position | Shares (Direct) | Shares (Indirect) | Report Date |
|---|---|---|---|---|
| Upstream Llc Ai | - | 5,494,410 | 0 | 17 Oct, 2024 |
| Upstream Llc Ai | - | 5,494,410 | 0 | 17 Oct, 2024 |
| Erez Chimovits | - | 0 | 4,554,873 | 17 Oct, 2024 |
| Advisors Llc Orbimed | - | 0 | 4,554,873 | 17 Oct, 2024 |
| Biomedical Innovation Master Investors (Cayman) Ii L.P. Wellington | - | 894,733 | 0 | 15 Oct, 2024 |
| Everett Rand Sutherland | Chief Executive Officer | 72,907 | 0 | 17 Mar, 2026 |
| Aaron Deykin | Chief Medical Officer | 32,687 | 0 | 17 Mar, 2026 |
| Michael Gray | Cfo And Coo | 29,648 | 0 | 17 Mar, 2026 |
| Adam Houghton | Chief Business Officer | 24,301 | 0 | 17 Mar, 2026 |
| Allison Ambrose | General Counsel | 16,525 | 0 | 17 Mar, 2026 |
* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.
| Transaction Date | Insider Name | Security Class | Transaction Type | Shares Traded | Price | Shares Remaining | Ownership | Code |
|---|---|---|---|---|---|---|---|---|
| 16 Mar, 2026 | Michael Gray | Common Stock | D | 852 | $9.29 | 29,648 | D | S |
| 16 Mar, 2026 | Everett Rand Sutherland | Common Stock | D | 2,093 | $9.29 | 72,907 | D | S |
| 16 Mar, 2026 | Allison Ambrose | Common Stock | D | 475 | $9.29 | 16,525 | D | S |
| 16 Mar, 2026 | Adam Houghton | Common Stock | D | 699 | $9.29 | 24,301 | D | S |
| 16 Mar, 2026 | Aaron Deykin | Common Stock | D | 894 | $9.29 | 32,687 | D | S |
| 02 Jan, 2026 | Adam Houghton | Common Stock | A | 25,000 | $0.00 | 25,000 | D | A |
| 02 Jan, 2026 | Allison Ambrose | Common Stock | A | 17,000 | $0.00 | 17,000 | D | A |
| 02 Jan, 2026 | Michael Gray | Common Stock | A | 30,500 | $0.00 | 30,500 | D | A |
| 02 Jan, 2026 | Aaron Deykin | Common Stock | A | 32,000 | $0.00 | 33,581 | D | A |
| 02 Jan, 2026 | Everett Rand Sutherland | Common Stock | A | 75,000 | $0.00 | 75,000 | D | A |
| 02 Jan, 2026 | Michael Gray | Stock Option (Right to Buy) | A | 91,500 | $0.00 | 91,500 | D | A |
| 02 Jan, 2026 | Everett Rand Sutherland | Stock Option (Right to Buy) | A | 225,000 | $0.00 | 225,000 | D | A |
| 02 Jan, 2026 | Adam Houghton | Stock Option (Right to Buy) | A | 75,000 | $0.00 | 75,000 | D | A |
| 02 Jan, 2026 | Allison Ambrose | Stock Option (Right to Buy) | A | 51,000 | $0.00 | 51,000 | D | A |
| 02 Jan, 2026 | Aaron Deykin | Stock Option (Right to Buy) | A | 96,000 | $0.00 | 96,000 | D | A |
| 10 Jun, 2025 | Ronald C Jr Renaud | Stock Option (Right to Buy) | A | 17,096 | $0.00 | 17,096 | D | A |
| 10 Jun, 2025 | Liam Ratcliffe | Stock Option (Right to Buy) | A | 17,096 | $0.00 | 17,096 | D | A |
| 10 Jun, 2025 | Harold Edward Fleming | Stock Option (Right to Buy) | A | 17,096 | $0.00 | 17,096 | D | A |
| 10 Jun, 2025 | Erez Chimovits | Stock Option (Right to Buy) | A | 17,096 | $0.00 | 17,096 | D | A |
| 10 Jun, 2025 | Daniella Beckman | Stock Option (Right to Buy) | A | 17,096 | $0.00 | 17,096 | D | A |