Upstream Bio (UPB) Gross Margin (2024 - 2026)
Upstream Bio's quarterly Gross Margin came in at 380.95% in Q1 2026, down 10480.0% year-on-year from N/an in Q1 2025, and up 66.84% quarter-over-quarter from 1148.8% in Q4 2025.
Upstream Bio has reported Gross Margin for 3 years, with the latest figure at 380.95% in Q1 2026.
- For the quarter ending Q1 2026, Gross Margin fell 10480.0% year-over-year to 380.95%; the trailing twelve-month figure through Mar 2026 stood at 678.36% (down 40884.0% YoY), and the FY2025 full-year result was 706.34%, down 52870.0% from the prior year.
- Gross Margin for Q1 2026 stood at 380.95%, up from 1148.8% in the prior quarter.
- The five-year high for Gross Margin was 45.16% in Q1 2024, with the low at 1148.8% in Q4 2025.
- Average Gross Margin over 3 years is 420.78%, with a median of 276.15% recorded in 2025.
- Peak annual rise in Gross Margin reached 1320 bps in 2025, while the deepest fall reached 79856 bps in 2025.
- Tracing UPB's Gross Margin over 3 years: stood at 350.24% in 2024, then sank by 228 bps to 1148.8% in 2025, then soared by 67 bps to 380.95% in 2026.
- The last three Gross Margin figures came in at 380.95% (Q1 2026), 1148.8% (Q4 2025), and 272.18% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - | - |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - | - |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn | 79.04% |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - | - |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn | 86.85% |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn | 91.79% |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn | 82.22% |
| 10 | Upstream Bio | 454.22 Mn | 454.22 Mn | -3.94 Mn | -380.95% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -380.95% |
| Dec 31, 2025 | -1,148.80% |
| Sep 30, 2025 | -272.18% |
| Jun 30, 2025 | -967.24% |
| Mar 31, 2025 | -276.15% |
| Dec 31, 2024 | -350.24% |
| Sep 30, 2024 | -258.98% |
| Jun 30, 2024 | -177.65% |
| Mar 31, 2024 | 45.16% |