Upstream Bio (UPB) Gross Margin (2024 - 2026)
Upstream Bio's (UPB) quarterly Gross Margin came in at 380.95% in Q1 2026, down 10480.0% year-on-year from N/an in Q1 2025, and up 66.84% quarter-over-quarter from 1148.8% in Q4 2025.
Upstream Bio (UPB) Gross Margin (2024 - 2026) Analysis & Trends
Upstream Bio's Gross Margin history runs 3 years deep, the most recent figure standing at 380.95% for Q1 2026.
- On a quarterly basis, Gross Margin fell 10480.0% year-over-year to 380.95% in Q1 2026; TTM through Mar 2026 was 678.36%, a 40884.0% decrease from a year earlier, with the FY2025 full-year figure at 706.34%, down 52870.0% from the prior year.
- Gross Margin rose to 380.95% in Q1 2026 per UPB's latest filing, from 1148.8% in the prior quarter.
- Across five years, Gross Margin topped out at 45.16% in Q1 2024 and bottomed at 1148.8% in Q4 2025.
- The 3-year median for Gross Margin is 276.15% (2025), against an average of 420.78%.
- Biggest YoY gain for Gross Margin was 1320 bps in 2025; the steepest drop was 79856 bps in 2025.
- Year by year, Gross Margin stood at 350.24% in 2024, then plunged by 228 bps to 1148.8% in 2025, then surged by 67 bps to 380.95% in 2026.
- Per Business Quant, the three latest UPB Gross Margin figures stand at 380.95% (Q1 2026), 1148.8% (Q4 2025), and 272.18% (Q3 2025).
Powered by 
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 66,079.99 Bn | 66,079.71 Bn | - | - |
| 2 | Nanobiotix | 1,912.79 Bn | 1,912.73 Bn | - | - |
| 3 | Akari Therapeutics | 1,022.34 Bn | 1,022.34 Bn | - | - |
| 4 | BeOne Medicines | 471.68 Bn | 466.89 Bn | 1.35 Bn | 88.95% |
| 5 | Vertex Pharmaceuticals | 122.31 Bn | 115.06 Bn | 2.59 Bn | 86.85% |
| 6 | Regeneron Pharmaceuticals | 70.24 Bn | 61.49 Bn | 3.31 Bn | 91.79% |
| 7 | Belite Bio | 63.01 Bn | 63.01 Bn | - | - |
| 8 | Argenx Se | 56.02 Bn | 50.83 Bn | 1.41 Bn | 90.68% |
| 9 | Alnylam Pharmaceuticals | 37.46 Bn | 34.45 Bn | 959.66 Mn | 82.22% |
| 10 | Upstream Bio | 350.44 Mn | 350.44 Mn | -3.94 Mn | -380.95% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -380.95% |
| Dec 31, 2025 | -1,148.80% |
| Sep 30, 2025 | -272.18% |
| Jun 30, 2025 | -967.24% |
| Mar 31, 2025 | -276.15% |
| Dec 31, 2024 | -350.24% |
| Sep 30, 2024 | -258.98% |
| Jun 30, 2024 | -177.65% |
| Mar 31, 2024 | 45.16% |