Upstream Bio (UPB) Gross Margin (2024 - 2026)
Upstream Bio (UPB) recorded Gross Margin of -425.87% in Q2 2026, up 541.36 percentage points from -967.24% a year earlier but down 44.93 percentage points from the prior quarter.
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Analysis
Upstream Bio (UPB) Gross Margin (2024 - 2026) Analysis & Trends
On a TTM basis, Upstream Bio's Gross Margin came in at -530.84% as of Jun 30, 2026, down 4.03 percentage points year-over-year; for FY2025, it was -706.34%, down 528.70 percentage points from FY2024.
- Across earlier years, Gross Margin came in at -177.64% in FY2024 (-135.91 pp) and -41.72% in FY2023.
- Quarterly Gross Margin has ranged from -1148.80% in Q4 2025 to 45.16% in Q1 2024 over the past five years.
- On a year-over-year basis, Gross Margin rose in 1 of the last six quarters, with an average year-over-year change of -247.68 percentage points.
- Per Business Quant, the preceding three quarters came in at -380.95% (Q1 2026), -1148.80% (Q4 2025) and -272.18% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 68.19% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 74.74% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | 73.54% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 78.02% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 83.60% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 72.04% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | 79.76% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 72.78% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 85.33% |
| 10 | Upstream Bio | 290.29 Mn | 290.29 Mn | -3.29 Mn | -425.87% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -425.87% |
| Mar 31, 2026 | -380.95% |
| Dec 31, 2025 | -1,148.80% |
| Sep 30, 2025 | -272.18% |
| Jun 30, 2025 | -967.24% |
| Mar 31, 2025 | -276.15% |
| Dec 31, 2024 | -350.24% |
| Sep 30, 2024 | -258.98% |
| Jun 30, 2024 | -177.65% |
| Mar 31, 2024 | 45.16% |
API Access
Upstream Bio Gross Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=gross-margin&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "gross-margin", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=gross-margin&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();