Upstream Bio (UPB) Gross Margin (2024 - 2026)

Upstream Bio's Gross Margin history runs 3 years deep, the most recent figure standing at 380.95% for Q1 2026.

• In Q1 2026, Gross Margin fell 10480.0% year-over-year to 380.95%; the TTM figure through Mar 2026 stood at 678.36% (down 40884.0% YoY), while the FY2025 annual figure was 706.34%, down 52870.0% from the prior year.
• Gross Margin for Q1 2026 stood at 380.95%, up from 1148.8% in the prior quarter.
• The five-year high for Gross Margin was 45.16% in Q1 2024, with the low at 1148.8% in Q4 2025.
• The 3-year median for Gross Margin is 276.15% (2025), against an average of 420.78%.
• Peak annual rise in Gross Margin reached 1320 bps in 2025, while the deepest fall reached 79856 bps in 2025.
• Upstream Bio's Gross Margin stood at 350.24% in 2024, then sank by 228 bps to 1148.8% in 2025, then jumped by 67 bps to 380.95% in 2026.
• Business Quant data shows UPB's Gross Margin at 380.95% in Q1 2026, 1148.8% in Q4 2025, and 272.18% in Q3 2025.