Upstream Bio (UPB) Gross Margin (2024 - 2026)

Upstream Bio's Gross Margin history runs 3 years deep, the most recent figure standing at 380.95% for Q1 2026.

• In Q1 2026, Gross Margin fell 10480.0% year-over-year to 380.95%; the TTM figure through Mar 2026 stood at 678.36% (down 40884.0% YoY), while the FY2025 annual figure was 706.34%, down 52870.0% from the prior year.
• Gross Margin was 380.95% for Q1 2026 at Upstream Bio, up from 1148.8% in the prior quarter.
• In the past five years, Gross Margin ranged from a high of 45.16% in Q1 2024 to a low of 1148.8% in Q4 2025.
• Historically, Gross Margin has averaged 420.78% across 3 years, with a median of 276.15% in 2025.
• Biggest YoY gain for Gross Margin was 1320 bps in 2025; the steepest drop was 79856 bps in 2025.
• A 3-year view of Gross Margin shows it stood at 350.24% in 2024, then slumped by 228 bps to 1148.8% in 2025, then surged by 67 bps to 380.95% in 2026.
• The last three Gross Margin figures came in at 380.95% (Q1 2026), 1148.8% (Q4 2025), and 272.18% (Q3 2025), per Business Quant data.