Upstream Bio (UPB) Gross Margin: 2023-2025

Historic Gross Margin for Upstream Bio (UPB) over the last 2 years, with Sep 2025 value amounting to -272.18%.

  • Upstream Bio's Gross Margin fell 1320.00% to -272.18% in Q3 2025 from the same period last year, while for Sep 2025 it was -522.76%, marking a year-over-year decrease of 44396.00%. This contributed to the annual value of -177.64% for FY2024, which is 13591.00% down from last year.
  • As of Q3 2025, Upstream Bio's Gross Margin stood at -272.18%, which was up 71.86% from -967.24% recorded in Q2 2025.
  • In the past 5 years, Upstream Bio's Gross Margin ranged from a high of 100.00% in Q3 2023 and a low of -967.24% during Q2 2025.
  • Its 3-year average for Gross Margin is -228.59%, with a median of -258.98% in 2024.
  • Data for Upstream Bio's Gross Margin shows a maximum YoY plummeted of 78,959bps (in 2025) over the last 5 years.
  • Over the past 3 years, Upstream Bio's Gross Margin (Quarterly) stood at 100.00% in 2023, then plummeted by 45,024bps to -350.24% in 2024, then plummeted by 1,320bps to -272.18% in 2025.
  • Its last three reported values are -272.18% in Q3 2025, -967.24% for Q2 2025, and -276.15% during Q1 2025.