Upstream Bio (UPB) Return on Capital Employed (2024 - 2026)

Upstream Bio's (UPB) quarterly Return on Capital Employed came in at 53.36% in Q1 2026, down 3274.0% year-on-year from 1.68% in Q1 2025, and down 19.48% quarter-over-quarter from 44.66% in Q4 2025.

Upstream Bio (UPB) Return on Capital Employed (2024 - 2026) Analysis & Trends

Upstream Bio's Return on Capital Employed history runs 3 years deep, the most recent figure standing at 53.36% for Q1 2026.

  • On a quarterly basis, Return on Capital Employed fell 3274.0% year-over-year to 53.36% in Q1 2026; TTM through Mar 2026 was 53.36%, a 3274.0% decrease from a year earlier, with the FY2025 full-year figure at 39.66%, down 1273.0% from the prior year.
  • Return on Capital Employed fell to 53.36% in Q1 2026 per UPB's latest filing, from 44.66% in the prior quarter.
  • Across five years, Return on Capital Employed topped out at 20.63% in Q1 2025 and bottomed at 53.36% in Q1 2026.
  • The 3-year median for Return on Capital Employed is 32.06% (2025), against an average of 34.2%.
  • Across the five-year window, Return on Capital Employed slumped 2222 bps in 2025 and tumbled 3274 bps in 2026, its largest moves.
  • Year by year, Return on Capital Employed stood at 22.44% in 2024, then plunged by 99 bps to 44.66% in 2025, then declined by 19 bps to 53.36% in 2026.
  • Per Business Quant, the three latest UPB Return on Capital Employed figures stand at 53.36% (Q1 2026), 44.66% (Q4 2025), and 35.67% (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -31.80%
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 10.46%
4 NuCana 279.75 Bn 279.75 Bn - -68.47%
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 21.10%
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 10.19%
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - -68.84%
10 Upstream Bio 347.73 Mn 347.73 Mn -3.94 Mn -53.36%

Historic Data

Download Data
DateValue
Mar 31, 2026 -53.36%
Dec 31, 2025 -44.66%
Sep 30, 2025 -35.67%
Jun 30, 2025 -28.44%
Mar 31, 2025 -20.63%
Dec 31, 2024 -22.44%