Upstream Bio (UPB) Return on Capital Employed (2024 - 2026)
Upstream Bio's quarterly Return on Capital Employed came in at 53.36% in Q1 2026, down 3274.0% year-on-year from 1.68% in Q1 2025, and down 19.48% quarter-over-quarter from 44.66% in Q4 2025.
Upstream Bio has reported Return on Capital Employed for 3 years, with the latest figure at 53.36% in Q1 2026.
- For the quarter ending Q1 2026, Return on Capital Employed fell 3274.0% year-over-year to 53.36%; the trailing twelve-month figure through Mar 2026 stood at 53.36% (down 3274.0% YoY), and the FY2025 full-year result was 39.66%, down 1273.0% from the prior year.
- Return on Capital Employed for Q1 2026 stood at 53.36%, down from 44.66% in the prior quarter.
- The five-year high for Return on Capital Employed was 20.63% in Q1 2025, with the low at 53.36% in Q1 2026.
- Average Return on Capital Employed over 3 years is 34.2%, with a median of 32.06% recorded in 2025.
- Year-over-year, Return on Capital Employed slumped 2222 bps in 2025 and tumbled 3274 bps in 2026.
- Tracing UPB's Return on Capital Employed over 3 years: stood at 22.44% in 2024, then sank by 99 bps to 44.66% in 2025, then fell by 19 bps to 53.36% in 2026.
- The last three Return on Capital Employed figures came in at 53.36% (Q1 2026), 44.66% (Q4 2025), and 35.67% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - | 450.31% |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - | - |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn | 51.73% |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - | - |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - | -107.40% |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn | 21.10% |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn | 10.19% |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn | 20.34% |
| 10 | Upstream Bio | 454.22 Mn | 454.22 Mn | -3.94 Mn | -53.36% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -53.36% |
| Dec 31, 2025 | -44.66% |
| Sep 30, 2025 | -35.67% |
| Jun 30, 2025 | -28.44% |
| Mar 31, 2025 | -20.63% |
| Dec 31, 2024 | -22.44% |