Upstream Bio (UPB) Return on Capital Employed (2024 - 2026)
Upstream Bio's (UPB) quarterly Return on Capital Employed came in at 53.36% in Q1 2026, down 3274.0% year-on-year from 1.68% in Q1 2025, and down 19.48% quarter-over-quarter from 44.66% in Q4 2025.
Upstream Bio (UPB) Return on Capital Employed (2024 - 2026) Analysis & Trends
Upstream Bio's Return on Capital Employed history runs 3 years deep, the most recent figure standing at 53.36% for Q1 2026.
- On a quarterly basis, Return on Capital Employed fell 3274.0% year-over-year to 53.36% in Q1 2026; TTM through Mar 2026 was 53.36%, a 3274.0% decrease from a year earlier, with the FY2025 full-year figure at 39.66%, down 1273.0% from the prior year.
- Return on Capital Employed fell to 53.36% in Q1 2026 per UPB's latest filing, from 44.66% in the prior quarter.
- Across five years, Return on Capital Employed topped out at 20.63% in Q1 2025 and bottomed at 53.36% in Q1 2026.
- The 3-year median for Return on Capital Employed is 32.06% (2025), against an average of 34.2%.
- Across the five-year window, Return on Capital Employed slumped 2222 bps in 2025 and tumbled 3274 bps in 2026, its largest moves.
- Year by year, Return on Capital Employed stood at 22.44% in 2024, then plunged by 99 bps to 44.66% in 2025, then declined by 19 bps to 53.36% in 2026.
- Per Business Quant, the three latest UPB Return on Capital Employed figures stand at 53.36% (Q1 2026), 44.66% (Q4 2025), and 35.67% (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | -31.80% |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 10.46% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -68.47% |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 21.10% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 10.19% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | - |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | -68.84% |
| 10 | Upstream Bio | 347.73 Mn | 347.73 Mn | -3.94 Mn | -53.36% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -53.36% |
| Dec 31, 2025 | -44.66% |
| Sep 30, 2025 | -35.67% |
| Jun 30, 2025 | -28.44% |
| Mar 31, 2025 | -20.63% |
| Dec 31, 2024 | -22.44% |