Upstream Bio (UPB) Invested Capital: 2023-2025

Historic Invested Capital for Upstream Bio (UPB) over the last 2 years, with Sep 2025 value amounting to $378.6 million.

  • Upstream Bio's Invested Capital rose 336.16% to $378.6 million in Q3 2025 from the same period last year, while for Sep 2025 it was $378.6 million, marking a year-over-year increase of 336.16%. This contributed to the annual value of $469.9 million for FY2024, which is 481.60% up from last year.
  • As of Q3 2025, Upstream Bio's Invested Capital stood at $378.6 million, which was down 7.38% from $408.7 million recorded in Q2 2025.
  • Upstream Bio's 5-year Invested Capital high stood at $469.9 million for Q4 2024, and its period low was -$160.3 million during Q3 2024.
  • Over the past 3 years, Upstream Bio's median Invested Capital value was -$112.2 million (recorded in 2023), while the average stood at $114.1 million.
  • Over the last 5 years, Upstream Bio's Invested Capital had its largest YoY gain of 481.60% in 2024, and its largest YoY loss of 42.87% in 2024.
  • Quarterly analysis of 3 years shows Upstream Bio's Invested Capital stood at -$123.1 million in 2023, then skyrocketed by 481.60% to $469.9 million in 2024, then soared by 336.16% to $378.6 million in 2025.
  • Its Invested Capital stands at $378.6 million for Q3 2025, versus $408.7 million for Q2 2025 and $445.6 million for Q1 2025.