Upstream Bio (UPB) EBT Margin (2023 - 2026)
Upstream Bio's quarterly EBT Margin came in at 3922.73% in Q1 2026, up 89529.0% year-on-year from N/an in Q1 2025, and up 38.36% quarter-over-quarter from 6364.22% in Q4 2025.
Upstream Bio has reported EBT Margin for 4 years, with the latest figure at 3922.73% in Q1 2026.
- For the quarter ending Q1 2026, EBT Margin rose 89529.0% year-over-year to 3922.73%; the trailing twelve-month figure through Mar 2026 stood at 4717.61% (down 126970.0% YoY), and the FY2025 full-year result was 5025.51%, down 225585.0% from the prior year.
- EBT Margin for Q1 2026 stood at 3922.73%, up from 6364.22% in the prior quarter.
- The five-year high for EBT Margin was 1265.54% in Q3 2023, with the low at 6364.22% in Q4 2025.
- Average EBT Margin over 4 years is 3594.38%, with a median of 3465.25% recorded in 2024.
- Year-over-year, EBT Margin plunged 289897 bps in 2025 and jumped 89529 bps in 2026.
- Tracing UPB's EBT Margin over 4 years: stood at 2846.89% in 2023, then dropped by 22 bps to 3465.25% in 2024, then tumbled by 84 bps to 6364.22% in 2025, then soared by 38 bps to 3922.73% in 2026.
- The last three EBT Margin figures came in at 3922.73% (Q1 2026), 6364.22% (Q4 2025), and 4938.36% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - | - |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - | - |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn | -6.40% |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - | - |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn | 41.95% |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn | 23.05% |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn | 18.99% |
| 10 | Upstream Bio | 454.22 Mn | 454.22 Mn | -3.94 Mn | -3,922.73% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -3,922.73% |
| Dec 31, 2025 | -6,364.22% |
| Sep 30, 2025 | -4,938.36% |
| Jun 30, 2025 | -4,259.98% |
| Mar 31, 2025 | -4,818.02% |
| Dec 31, 2024 | -3,465.25% |
| Sep 30, 2024 | -2,634.10% |
| Jun 30, 2024 | -2,875.10% |
| Mar 31, 2024 | -2,147.97% |
| Dec 31, 2023 | -2,846.89% |
| Sep 30, 2023 | -1,265.54% |