Upstream Bio (UPB) EBT Margin (2023 - 2026)
Upstream Bio (UPB) recorded EBT Margin of -5137.00% in Q2 2026, down 877.02 percentage points from -4259.98% a year earlier and down 1214.27 percentage points from the prior quarter.
Powered by 
Analysis
Upstream Bio (UPB) EBT Margin (2023 - 2026) Analysis & Trends
On a TTM basis, Upstream Bio's EBT Margin came in at -4956.05% as of Jun 30, 2026, down 1121.42 percentage points year-over-year; for FY2025, it came in at -5025.51%, down 2255.85 percentage points from FY2024.
- Across earlier years, EBT Margin came in at -2769.66% in FY2024 (-1259.20 pp) and -1510.46% in FY2023.
- Quarterly EBT Margin has ranged from -6364.22% in Q4 2025 to -1265.54% in Q3 2023 over the past five years.
- On a year-over-year basis, EBT Margin rose in 1 of the last eight quarters, with an average year-over-year change of -1403.35 percentage points.
- Peak year-over-year performance for EBT Margin in the last five years was a gain of 895.29 percentage points in Q1 2026, against a drop of 2898.97 percentage points in Q4 2025 at the low end.
- Per Business Quant, the preceding three quarters came in at -3922.73% (Q1 2026), -6364.22% (Q4 2025) and -4938.36% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 26.66% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 25.18% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -4.11% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 29.63% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 18.19% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 27.53% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -131.41% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | -4.34% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 41.75% |
| 10 | Upstream Bio | 290.29 Mn | 290.29 Mn | -3.29 Mn | -5,137.00% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -5,137.00% |
| Mar 31, 2026 | -3,922.73% |
| Dec 31, 2025 | -6,364.22% |
| Sep 30, 2025 | -4,938.36% |
| Jun 30, 2025 | -4,259.98% |
| Mar 31, 2025 | -4,818.02% |
| Dec 31, 2024 | -3,465.25% |
| Sep 30, 2024 | -2,634.10% |
| Jun 30, 2024 | -2,875.10% |
| Mar 31, 2024 | -2,147.97% |
| Dec 31, 2023 | -2,846.89% |
| Sep 30, 2023 | -1,265.54% |
API Access
Upstream Bio EBT Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebt-margin&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebt-margin", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebt-margin&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();