Upstream Bio (UPB) EBT Margin (2023 - 2026)
Upstream Bio's (UPB) quarterly EBT Margin came in at 5975.44% in Q1 2026, up 18411.0% year-on-year from N/an in Q1 2025, and up 80.51% quarter-over-quarter from 30657.19% in Q4 2025.
Upstream Bio (UPB) EBT Margin (2023 - 2026) Analysis & Trends
Upstream Bio's EBT Margin history runs 4 years deep, the most recent figure standing at 5975.44% for Q1 2026.
- On a quarterly basis, EBT Margin rose 18411.0% year-over-year to 5975.44% in Q1 2026; TTM through Mar 2026 was 14569.3%, a 603162.0% decrease from a year earlier, with the FY2025 full-year figure at 10711.46%, down 493479.0% from the prior year.
- EBT Margin improved to 5975.44% in Q1 2026 per UPB's latest filing, from 30657.19% in the prior quarter.
- Across five years, EBT Margin topped out at 1265.54% in Q3 2023 and bottomed at 30657.19% in Q4 2025.
- The 4-year median for EBT Margin is 8415.16% (2024), against an average of 10320.26%.
- Across the five-year window, EBT Margin plunged 1556616 bps in 2025 and soared 18411 bps in 2026, its largest moves.
- Year by year, EBT Margin stood at 11668.0% in 2023, then declined by 29 bps to 15091.03% in 2024, then slumped by 103 bps to 30657.19% in 2025, then jumped by 81 bps to 5975.44% in 2026.
- Per Business Quant, the three latest UPB EBT Margin figures stand at 5975.44% (Q1 2026), 30657.19% (Q4 2025), and 19512.3% (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 17.13% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 41.95% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 23.05% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 34.77% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Upstream Bio | 347.73 Mn | 347.73 Mn | -3.94 Mn | -5,975.44% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -5,975.44% |
| Dec 31, 2025 | -30,657.19% |
| Sep 30, 2025 | -19,512.30% |
| Jun 30, 2025 | -8,980.47% |
| Mar 31, 2025 | -6,159.54% |
| Dec 31, 2024 | -15,091.03% |
| Sep 30, 2024 | -8,415.16% |
| Jun 30, 2024 | -3,445.88% |
| Mar 31, 2024 | -2,352.34% |
| Dec 31, 2023 | -11,668.00% |
| Sep 30, 2023 | -1,265.54% |