Upstream Bio (UPB) EBT Margin (2023 - 2026)
Upstream Bio (UPB) posted quarterly EBT Margin of 5975.44% for Q1 2026, up 18411.0% year-over-year from N/an in Q1 2025, and up 80.51% quarter-over-quarter from 30657.19% in Q4 2025.
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Upstream Bio (UPB) EBT Margin (2023 - 2026) Analysis & Trends
Upstream Bio's EBT Margin history runs 4 years deep, the most recent figure standing at 5975.44% for Q1 2026.
- In Q1 2026, EBT Margin rose 18411.0% year-over-year to 5975.44%; the TTM figure through Mar 2026 stood at 14569.3% (down 603162.0% YoY), while the FY2025 annual figure was 10711.46%, down 493479.0% from the prior year.
- EBT Margin for Q1 2026 stood at 5975.44%, up from 30657.19% in the prior quarter.
- The five-year high for EBT Margin was 1265.54% in Q3 2023, with the low at 30657.19% in Q4 2025.
- The 4-year median for EBT Margin is 8415.16% (2024), against an average of 10320.26%.
- The sharpest annual moves came in 2025 and 2026: EBT Margin tumbled 1556616 bps in 2025, then soared 18411 bps in 2026.
- Upstream Bio's EBT Margin stood at 11668.0% in 2023, then dropped by 29 bps to 15091.03% in 2024, then tumbled by 103 bps to 30657.19% in 2025, then soared by 81 bps to 5975.44% in 2026.
- Business Quant data shows UPB's EBT Margin at 5975.44% in Q1 2026, 30657.19% in Q4 2025, and 19512.3% in Q3 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 41.75% |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 35.61% |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | 35.78% |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -528.97% |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | - |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 18.33% |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | 13.77% |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 12.09% |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -2.67% |
| 10 | Upstream Bio | 327.95 Mn | 327.95 Mn | -3.29 Mn | -5,137.00% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -5,137.00% |
| Mar 31, 2026 | -4,259.67% |
| Dec 31, 2025 | -6,364.22% |
| Sep 30, 2025 | -4,938.36% |
| Jun 30, 2025 | -4,259.98% |
| Mar 31, 2025 | -5,586.57% |
| Dec 31, 2024 | -3,465.25% |
| Sep 30, 2024 | -2,634.10% |
| Jun 30, 2024 | -3,445.88% |
| Mar 31, 2024 | -2,352.34% |
| Dec 31, 2023 | -2,846.89% |
| Sep 30, 2023 | -1,265.54% |